COX

Inhibitory Selectivity

Catalog No.	Inhibitor Name	COX-1	COX-2
A10193	Celecoxib		****
A10461	Ibuprofen	*	*
A10474	Indomethacin	**	*
A11918	Rofecoxib		****
A10304	Diclofenac Sodium	***	***
A11695	Lornoxicam	****	****
A10623	Naproxen Sodium	*	*
A13342	Valdecoxib		****
A11693	Tolfenamic Acid		***
A16399	Amfenac Sodium Monohydrate	**	***
A11694	Nimesulide		*
A12520	Meclofenamate Sodium	****	***
A16428	Carprofen		****
A10636	Nepafenac
A10878	Sulindac
A10565	Meloxicam
A10820	Aspirin
A11906	Phenacetin
A10736	Piroxicam
A10462	Ibuprofen Lysine
A11641	Pranoprofen
A10090	Asaraldehyde
A11692	Acemetacin
A13244	Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Radicicol

Catalog No. A11768
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Hsp90/SRC/COX-2 抑制剂

Radicicol是Hsp90，SRC和Cox-2的有效抑制剂。了解更多

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Flufenamic acid

Catalog No. A13333
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COX 抑制剂

Flufenamic acid是一种非甾体类抗炎药（NSAID）。抑制钙激活的氯离子通道（CaCC）。也增加通过TRPC6通道的电流，并抑制通过TRPC3和TRPC7通道的电流。了解更多

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Pranoprofen

Catalog No. A11641
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COX 抑制剂

Pranoprofen是一种用于眼科的非甾体类抗炎药。了解更多

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(-)-Epicatechin

Catalog No. A12043
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COX-1 抑制剂

(-)-Epicatechin是绿茶的天然产物。(-)表儿茶素是cox-1的抑制剂。了解更多

Product Citations (4)

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- A S D'Costa, .et al. Inhibition of starch digestion by flavonoids: Role of flavonoid-amylase binding kinetics, Food Chem, 2020, Oct 1;341(Pt 2):128256 PMID: 33035827
- Mihaela Tudorache, .et al. Phenolic compounds mediate aggregation of water-soluble polysaccharides and change their rheological properties: Effect of different phenolic compounds, Food Hydrocoll, 2019, 97, Dec, 105193
- Md Shajedul Islam, .et al. UV-C irradiation as an alternative disinfection technique: Study of its effect on polyphenols and antioxidant activity of apple juice, Innovative food science & emerging technologies, 2016, v.34 pp. 344-351
- Islam MS, .et al. Effect of UV Irradiation on the Nutritional Quality and Cytotoxicity of Apple Juice, J Agric Food Chem, 2016, Oct 10 PMID: 27632812
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SC 560

Catalog No. A13023
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COX-1 抑制剂

SC 560是一种COX-1选择性抑制剂，IC50 值为9 nM。可以用作研究COX-1衍生的PG在炎症和疼痛中的作用的药理学工具。了解更多

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ATB 346

Catalog No. A13983
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COX-2 抑制剂

ATB-346具有类似于萘普生的抗炎特性，但其胃肠道毒性显着降低。了解更多

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Xanthohumol

Catalog No. A15919
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COX 抑制剂

Xanthohumol是一种来自啤酒花的烯丙基查尔酮，可抑制COX-1和COX-2活性并显示化学预防作用。了解更多

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Etoricoxib

Catalog No. A13770
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COX-2 抑制剂

Etoricoxib特异性结合并抑制环氧合酶2（COX-2），从而抑制花生四烯酸向前列腺素的转化。抑制COX-2可以诱导细胞凋亡并抑制肿瘤细胞的增殖和血管生成。了解更多

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Paradol

Catalog No. A15205
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COX-1 抑制剂

Paradol是几内亚胡椒（Aframomum melegueta）种子的活性风味成分。已发现Paradol具有抗氧化和抗肿瘤的促进作用。了解更多

Product Citations (2)

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- Taurin Hughes, .et al. Inhibition of Escherichia coli ATP synthase by dietary ginger phenolics, Int J Biol Macromol, 2021, Jul 1;182:2130-2143 PMID: 34087308
- Lihan Zhao, .et al. Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer, Sci Rep, 2020, Nov 5;10(1):19182 PMID: 33154433
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Meclofenamate Sodium

Catalog No. A12520
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COX 抑制剂

Meclofenamate Sodium是一种双重COX-1/COX-2抑制剂，IC50为40 nM和50 nM。了解更多

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