COX

Inhibitory Selectivity

Catalog No.	Inhibitor Name	COX-1	COX-2
A10193	Celecoxib		****
A10461	Ibuprofen	*	*
A10474	Indomethacin	**	*
A11918	Rofecoxib		****
A10304	Diclofenac Sodium	***	***
A11695	Lornoxicam	****	****
A10623	Naproxen Sodium	*	*
A13342	Valdecoxib		****
A11693	Tolfenamic Acid		***
A16399	Amfenac Sodium Monohydrate	**	***
A11694	Nimesulide		*
A12520	Meclofenamate Sodium	****	***
A16428	Carprofen		****
A10636	Nepafenac
A10878	Sulindac
A10565	Meloxicam
A10820	Aspirin
A11906	Phenacetin
A10736	Piroxicam
A10462	Ibuprofen Lysine
A11641	Pranoprofen
A10090	Asaraldehyde
A11692	Acemetacin
A13244	Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Pranoprofen

Catalog No. A11641
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COX 抑制剂

Pranoprofen是一种用于眼科的非甾体类抗炎药。了解更多

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Tepoxalin

Catalog No. A12879
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COX/5-LOX 抑制剂

Tepoxalin是花生四烯酸代谢的双重环氧合酶/5-脂氧合酶抑制剂，具有有效的抗炎活性和良好的胃肠道功能。了解更多

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Licofelone

Catalog No. A11697
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COX/LOX 抑制剂

Licofelone是一种COX/LOX双重抑制剂，被认为是治疗骨关节炎的药物。它可能会降低与其他仅抑制COX（环氧合酶）的非甾体类抗炎药有关的胃肠道毒性。利福非酮是第一种同时抑制两者的药物。了解更多

Product Citations (1)

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- Silke Neumann, .et al. Improved Antitumor Activity of a Therapeutic Melanoma Vaccine through the Use of the Dual COX-2/5-LO Inhibitor Licofelone, Front Immunol, 2016, 7: 537 PMID: 27994586
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Flunixin meglumine

Catalog No. A11686
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COX 抑制剂

Flunixin Meglumin是一种有效的环氧化酶（COX）抑制剂，用作止痛剂，具有抗炎和解热作用。了解更多

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- Yukari Nakajima, .et al. Near-Infrared Fluorescence Imaging Directly Visualizes Lymphatic Drainage Pathways and Connections between Superficial and Deep Lymphatic Systems in the Mouse Hindlimb, Sci Rep, 2018, 8: 7078 PMID: 29728629
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Acetaminophen

Catalog No. A10030
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COX 抑制剂

Acetaminophen (paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂，IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。它是广泛使用的解热和止痛药。了解更多

Product Citations (3)

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- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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Ampiroxicam

Catalog No. A16409
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COX 抑制剂

Ampiroxicam是一种非选择性的环氧合酶抑制剂，被用作抗炎药。了解更多

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Pravadoline (WIN 48098)

Catalog No. A10749
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COX 抑制剂

Pravadoline (WIN 48098)是抗炎和前列腺素合成抑制剂，通过抑制环氧合酶（COX）发挥作用。了解更多

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- Sharma P, .et al. [3 + 2]-Annulations of N-Hydroxy Allenylamines with Nitrosoarenes: One-Pot Synthesis of Substituted Indole Products, Org Lett, 2016, Feb 5;18(3):412-5 PMID: 26745849
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Phenylbutazone (Butazolidin, Butatron)

Catalog No. A10720
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COX 抑制剂

Phenylbutazone (Butazolidin,Butatron)是一种具有研究意义的化合物，它是一种抗炎和抗增殖剂。了解更多

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Diflunisal

Catalog No. A16166
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COX 抑制剂

Diflunisal是具有止痛和抗炎活性的水杨酸衍生物。了解更多

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Acemetacin (Emflex)

Catalog No. A11692
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COX 抑制剂

Acemetacin (Emflex)是一种非甾体类抗炎药，是吲哚美辛的乙醇酸酯，是一种环加氧酶抑制剂。了解更多

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Naproxen sodium

Catalog No. A10623
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COX 抑制剂

Naproxen sodium是一种非选择性的环氧合酶（COX）抑制剂，具有抗炎，解热和镇痛作用。对秋水仙碱引起的认知障碍和氧化应激具有神经保护作用。了解更多

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Sulindac (Clinoril)

Catalog No. A10878
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COX 抑制剂

Sulindac (Clinoril) 是一种非甾体类COX抑制剂，可有效抑制前列腺素的合成。了解更多

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Amfenac Sodium Monohydrate

Catalog No. A16399
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COX 抑制剂

Amfenac Sodium Monohydrate是一种非甾体止痛消炎药，带有乙酸部分。COX1和COX2的IC50值分别为250 nM和150 nM。了解更多

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