HMG-CoA Reductase

Inhibitory Selectivity

Catalog No.	Inhibitor Name	HMG-CoA Reductase
A10810	Rosuvastatin Calcium	**
A11877	Lovastatin	***
A11912	Pravastatin sodium	**
A11184	Clinofibrate	*
A11800	Atorvastatin Calcium
A13709	Mevastatin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Pitavastatin calcium (Livalo)

Catalog No. A10737
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HMG-CoA reductase 抑制剂

Pitavastatin calcium (Livalo)是HMGCR（HMG-CoA还原酶）酶的竞争性抑制剂，可降低LDL胆固醇的合成。了解更多

Product Citations (4)

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- Weizhen Chen, .et al. An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties, Biomaterials, 2021, 280:121260 PMID: 34823885
- Karis Tutuska, .et al. Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins, Cell Death Dis, 2020, Apr; 11(4): 274 PMID: 32332697
- D Jarmuzek, .et al. Phototransformations of pitavastatin - The inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, J Photochem Photobiol A Chem, 2019, November
- Marwan Ibrahim Abdullah, .et al. Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells, Sci Rep, 2017, 7: 8090 PMID: 28808351
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Pitavastatin Lactone

Catalog No. A13896
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HMG-CoA reductase 抑制剂

Pitavastatin Lactone是HMG-CoA还原酶抑制剂。了解更多

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Pravastatin sodium

Catalog No. A11912
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HMG-CoA reductase 抑制剂

Pravastatin sodium是3-羟基-3-甲基辅酶A（HMG-CoA）还原酶的水溶性竞争性抑制剂。有效阻断体内胆固醇合成（Ki?1 nM）并显示出心脏保护特性。了解更多

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Mevastatin

Catalog No. A13709
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HMG-CoA reductase 抑制剂

Mevastatin是HMG-CoA还原酶的抑制剂。了解更多

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Lovastatin (Mevacor)

Catalog No. A11877
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HMG-CoA reductase 抑制剂

Lovastatin (Mevacor)是HMG-CoA还原酶的抑制剂，IC50为3.4 nM，用于降低胆固醇。了解更多

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Atorvastatin calcium

Catalog No. A11800
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HMG-CoA reductase 抑制剂

Atorvastatin calcium (Lipitor)是HMG-CoA还原酶的抑制剂，可用作降低胆固醇的药物，可阻止胆固醇的产生。了解更多

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Atorvastatin

Catalog No. A13743
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HMG-CoA reductase 抑制剂

Atorvastatin是一种HMG-CoA还原酶抑制剂（IC50 = 154 nM），可有效治疗高胆固醇血症和某些血脂异常。了解更多

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- Huang Y, .et al. Downregulation of connective tissue growth factor reduces migration and invasiveness of osteosarcoma cells, Mol Med Rep, 2016, Feb;13(2):1888-94 PMID: 26707502
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Rosuvastatin calcium (Crestor)

Catalog No. A10810
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HMG-CoA reductase 抑制剂

Rosuvastatin calcium (Crestor)是他汀类药物中的一员，用于治疗高胆固醇及相关疾病，并预防心血管疾病。罗苏伐他汀是一种竞争性HMG-CoA reductase抑制剂，无细胞试验中IC50为11 nM。了解更多

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Swertiamarin

Catalog No. A12128
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HMG-CoA reductase 抑制剂

Swertiamarin通过抑制高胆固醇喂养大鼠的HMG-CoA还原酶活性显示出作为抗动脉粥样硬化剂的潜力。了解更多

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