MEK

Inhibitory Selectivity

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Catalog No.	Inhibitor Name	MEK	MEK1	MEK1/2	MEK2	MEK5	Other
A10089	Pimasertib			*
A10115	AZD8330						ERK phosphorylation
A10150	BIX 02188					***	ERK5,TGFβR1
A10151	BIX 02189					****	ERK5,TGFβR1
A10212	PD184352		**		**
A10256	PD0325901	****
A10257	Selumetinib		***
A10453	Honokiol						Akt-phosphorylation
A10704	PD318088
A10705	PD98059		*

Showing 1 to 10 of 22 entries

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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BI-847325

Catalog No. A15762
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MEK/Aurora 抑制剂

BI-847325是一种生物利用型选择性MEK/Aurora双重激酶抑制剂，对于非洲爪蟾Aurora B，人Aurora A和Aurora C以及IC50分别为3 nM，25 nM，15 nM，25 nM和4 nM IC50人MEK1和MEK2。了解更多

Product Citations (2)

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- Hilda Samimi, .et al. Alginate-based 3D cell culture technique to evaluate the half-maximal inhibitory concentration: an in vitro model of anticancer drug study for anaplastic thyroid carcinoma, Thyroid Res, 2021, Dec 3;14(1):27 PMID: 34861882
- Hilda Samimi, .et al. Transcript-level regulation of MALAT1-mediated cell cycle and apoptosis genes using dual MEK/Aurora kinase inhibitor "BI-847325" on anaplastic thyroid carcinoma, DARU J Pharm Sci, 2019, 1-7 PMID: 31077090