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￥ 0.00 Trk Receptors
| Catalog No. | Inhibitor Name | TrkA | TrkB | TrkC | Trk receptor | Other |
|---|---|---|---|---|---|---|
| A11059 | BMS-754807 | ** | *** | Insulin Receptor,IGF-1R,Met | ||
| A16238 | GW441756 | **** | ||||
| A16259 | Sitravatinib (MGCD516) | *** | * | DDR2,EPHA3,Axl | ||
| A13877 | ANA-12 | * | ||||
| A13730 | GNF-5837 | ** | * | ** | ||
| A15801 | Entrectinib (RXDX-101) | ALK,ROS1 | ||||
| A10053 | Tyrphostin AG 879 | * | Her2 | |||
| A10715 | Danusertib (PHA-739358) | * | Aurora A, Abl, RET, FGFR1, Aurora C, Aurora B | |||
| A15494 | LM22A-4 | * | ||||
| A15974 | Larotrectinib (LOXO-101) sulfate | |||||
| A16123 | 7,8-Dihydroxyflavone |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
14 个项目
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Danusertib (PHA-739358)
Catalog No. A10715 Aurora 抑制剂Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂，在无细胞分析中的IC50为13 nM/79nM/61 nM，对Abl，TrkA，c-RET和FGFR1以及更低的浓度具有中等效力 对Lck，VEGFR2/3，c-Kit，CDK2等有效。 了解更多 -
ANA-12
Catalog No. A13877 -
LM22A-4
Catalog No. A15494 -
Entrectinib
Catalog No. A15801 TRK, ROS1, ALK 抑制剂Entrectinib，也称为RXDX-101和NMS-E628，是TrkA，TrkB和TrkC以及ROS1和ALK的小分子抑制剂，具有很高的效力和选择性。 了解更多 -
LOXO-101 (ARRY-470, Larotrectinib)
Catalog No. A15974 -
7,8-Dihydroxyflavone
Catalog No. A16123 TrkB 激动剂7,8-Dihydroxyflavone是一种选择性的酪氨酸激酶受体B（神经营养因子/原肌球蛋白受体激酶B；TrkB）激动剂，可用于帮助识别和区分由TrkB激活介导的生理效应和细胞信号通路。涉及神经保护，记忆，血管舒张和高血压。 了解更多 -
GW 441756
Catalog No. A16238 -
LOXO-101 sulfate
Catalog No. A16239 TRK 抑制剂LOXO-101 sulfate是一种小分子，设计用于阻断TRK家族的ATP结合位点，对TRKA，TRKB和TRKC激酶具有2至20 nM的细胞效力。 了解更多 -
Tyrphostin AG 879
Catalog No. A10053 -
AZ 23
Catalog No. A12666 -
Sitravatinib (MGCD516)
Catalog No. A16259
14 个项目
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