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￥ 0.00 Bcl-2 Family
| Catalog No. | Inhibitor Name | Bcl-2 | Bcl-B | Bcl-w | Bcl-xL | Mcl-1 | A1 | Bax | Other |
|---|---|---|---|---|---|---|---|---|---|
| A10255 | ABT-737 | **** | * | *** | *** | ||||
| A10022 | Navitoclax (ABT-263) | **** | **** | **** | ** | ** | |||
| A10665 | Obatoclax Mesylate | *** | |||||||
| A10955 | TW-37 | *** | * | *** | |||||
| A12500 | Venetoclax | **** | *** | **** | |||||
| A15004 | AT101 | ** | ** | *** | |||||
| A11448 | HA14-1 | * | |||||||
| A12823 | Sabutoclax | ** | ** | *** | ** | ||||
| A15545 | A-1210477 | **** | |||||||
| A14222 | UMI-77 | ** | |||||||
| A11988 | Gambogic Acid | * | * | **** | * | * | * | Caspase | |
| A12743 | BM-1074 | **** | **** | ||||||
| A13327 | WEHI-539 hydrochloride | **** | |||||||
| A15821 | BDA-366 | *** | |||||||
| A16061 | BH3I-1 | * | p53 | ||||||
| A16112 | A-1155463 | **** | |||||||
| A16190 | A-1331852 | **** | |||||||
| A16314 | Apogossypolone (ApoG2) |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
37 个项目
每页
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Pyridoclax (MR-29072)
Catalog No. A16380 -
Bax inhibitor peptide, negative control
Catalog No. A15338 -
Bax inhibitor peptide V5
Catalog No. A15337 Bax 抑制剂Bax inhibitor peptide V5，Bax易位至线粒体的细胞渗透性合成肽抑制剂；由Ku70设计的一种蛋白质，被认为可抑制Bax的线粒体易位。在体外抑制Bax介导的细胞凋亡。 了解更多 -
Bax inhibitor peptide P5
Catalog No. A15336 Bax 抑制剂Bax inhibitor peptide P5，Bax易位至线粒体的细胞渗透性合成肽抑制剂；由Ku70设计的一种蛋白质，被认为可抑制Bax的线粒体易位。在体外抑制Bax介导的细胞凋亡。 了解更多 -
Gambogic acid
Catalog No. A11988 Bcl-2 抑制剂Gambogic acid是从藤黄汉树中分离出的天然产物。藤黄酸激活半胱氨酸蛋白酶，EC50为0.78-1.64μM，并竞争性抑制Bcl-XL，Bcl-2，Bcl-W，Bcl-B，Bfl-1和Mcl-1，IC50为1.47、1.21、2.02、0.66、1.06和 分别为0.79μM。 了解更多 -
A-1210477
Catalog No. A15545 -
WEHI-539 hydrochloride
Catalog No. A13327 -
Apogossypolone (ApoG2)
Catalog No. A16314 -
Acetate gossypol
Catalog No. A14795 -
(S)-Gossypol acetic acid
Catalog No. A16323 (S)-Gossypol acetic acid是Bcl-2的抑制剂，在过表达Bcl-2（IC50，18.1μM）或Bcl-xL（IC50，22.9μM）的Jurkat细胞中有效诱导细胞死亡。 了解更多 -
BM-1074
Catalog No. A12743 -
(+)-Apogossypol
Catalog No. A16316 Bcl-2 family 抑制剂(+)-Apogossypol是Bcl-2家族蛋白的有效抑制剂。与Bcl-2，Bcl-XL，Mcl-1，Bcl-W和Bcl-B上的BH3肽结合位点竞争，但与Bfl-1竞争，IC50为0.5至2μM。 了解更多 -
TW-37
Catalog No. A10955 -
AT101 acetic acid
Catalog No. A13578 pan Bcl-2 抑制剂AT101 acetic acid对映体AT101与Bcl-2，Bcl-xL和Mcl-1结合，Ki分别为0.32μM，0.48μM和0.18μM；不抑制BIR3域和BID。 了解更多 -
A-1331852
Catalog No. A16190 -
UMI-77
Catalog No. A14222 -
A-385358
Catalog No. A17064 -
Maritoclax (Marinopyrrole A)
Catalog No. A17206 -
MCL-1/BCL-2-IN-3
Catalog No. A18385 Mcl-1 and Bcl-2 dual 抑制剂MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively. 了解更多 -
MCL-1/BCL-2-IN-4
Catalog No. A18380 Mcl-1 and Bcl-2 dual 抑制剂MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor. 了解更多 -
Bcl-2 Inhibitor
Catalog No. A13580 Bcl-2 抑制剂Bcl-2 Inhibitor包含两种互变异构体的混合物。一种有效的，细胞可渗透的Bcl-2抑制剂与Bak BH3肽竞争体外结合Bcl-2和Bcl-XL的作用（分别为IC50 = 10 uM和7 uM）。 了解更多 -
ABT-199 (Venetoclax)
Catalog No. A12500 Bcl-2 抑制剂ABT-199 (Venetoclax) 是一种所谓的BH3类似药物，旨在阻断Bcl 2蛋白的功能。 了解更多 -
Sabutoclax
Catalog No. A12823 Bcl-2 抑制剂Sabutoclax (BI-97C1)是pan-Bcl-2抑制剂，包括Bcl-xL，Bcl-2，Mcl-1和Bfl-1，IC50分别为0.31 μM，0.32 μM，0.20 μM和0.62 μM。 了解更多 -
Obatoclax mesylate (GX15-070)
Catalog No. A10665 Bcl-2 抑制剂Obatoclax Mesylate (GX15-070)是一种Bcl-2拮抗剂，拮抗所有抗凋亡Bcl-2家族蛋白（平均IC50，3 umol/L），包括Mcl-1（IC50，2.9 umol/L）和Bfl-1（IC50，5 umol/L）。 了解更多 -
ABT-263 (Navitoclax)
Catalog No. A10022 Bcl-2 抑制剂ABT-263 (Navitoclax)是一种有效的Bcl-2家族抑制剂 (Bcl-2，Bcl-xL和Bcl-w的Ki <1 nmol/L)。ABT-263对Bcl- xL，Bcl-2和Bcl-w，( Ki≤1nmol/ L) 维持高亲和力，但与Mcl-1和A1的结合更弱。 了解更多
37 个项目
每页