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JNK/c-Jun

JNK/c-Jun

Inhibitory Selectivity

Catalog No.	Inhibitor Name	JNK1	JNK2	JNK3	JNK	Other
A10860	SP600125	***	***		*	Aurora A,TrkA,FLT3
A12749	JNK-IN-8	****	***	****		Kit (V559D,T670I),Kit (V559D),RIOK2
A11969	JNK Inhibitor IX		*	**
A11296	AS 602801 (Bentamapimod)	**	**	*
A13564	CC-930 ( Tanzisertib)	**	***	****
A13565	CEP-1347	***
A13683	BI-78D3				*
A11352	CC-401
A15061	DB07268	****
A15136	JNK-IN-7					IRAK1, PIK3C3, PIP5K3 and PIP4K2C
A16036	IQ 3	*	*	**		NF-κB, AP1
A16039	SU 3327				*
A16054	TCS JNK 6o	****	****	**
A16062	IQ-1S	*	*	**
A15883	Vacquinol-1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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TCS JNK 5a

Catalog No. A11969
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JNK 抑制剂 IX

TCS JNK 5a是JNK2和JNK3的高度选择性抑制剂（对于JNK3，JNK2，JNK1和p38β，pIC50值分别为6.7、6.5，<5.0和<4.8）。了解更多

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c-JUN peptide

Catalog No. A16045
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JNK 抑制剂

c-JUN peptide是包含人c-Jun的JNK结合（δ）域的33-57位残基的肽。了解更多

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SR 3576

Catalog No. A16020
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JNK3 抑制剂

SR 3576是一种高效的选择性JNK3抑制剂（IC50 = 7 nM）；表现出比p38高2800倍的选择性。了解更多

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Anisomycin

Catalog No. A11271
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SAPKs/JNKs activator

Anisomycin是一种吡咯烷类抗生素，用作抑制蛋白质合成的抗真菌抗生素，也是SAPK/JNK的有效激活剂。了解更多

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- Ken Kobayashi, .et al. Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation, Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981
- Li Li, .et al. The mutual regulatory loop between TPTEP1 and miR-1303 in leukemogenesis of acute myeloid leukemia, Cancer Cell Int, 2021, May 13;21(1):260 PMID: 33985519
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Vacquinol-1

Catalog No. A15883
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MKK4-dependent macropinocytotic Activator

Vacquinol-1是MKK4激活剂，可快速选择性地诱导神经胶质瘤细胞死亡。了解更多

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IQ-1S

Catalog No. A16062
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JNK3 抑制剂

IQ-1S是一种选择性JNK3抑制剂，对于JNK1、2和3的IC50值分别为390、360和87 nM。了解更多

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AS601245

Catalog No. A21502
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cell-permeable JNK Inhibitor

AS601245 is a cell-permeable JNK Inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. 了解更多

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DTP3

Catalog No. A16059
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JNK 抑制剂

DTP3是选择性GADD45β/ MKK7抑制剂，可抑制癌症选择性NF-kB生存途径。了解更多

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TCS JNK 6o

Catalog No. A16054
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JNK 抑制剂

TCS JNK 6o是一种ATP竞争性选择性c-Jun N末端激酶（JNK）抑制剂。了解更多

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JIP-1 (153-163)

Catalog No. A16041
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JNK 抑制剂

JIP-1 (153-163)是c-Jun N末端激酶（JNK）的肽抑制剂，基于JNK相互作用蛋白1（JIP-1）的153-163残基。以微摩尔范围的亲和力与JNK结合，并最小程度地抑制p38和ERK。了解更多

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SU 3327

Catalog No. A16039
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JNK 抑制剂

SU 3327是JNK（c-Jun N-末端激酶）（IC50 = 0.7uM）的选择性抑制剂。显示SU 3327抑制JNK和JIP之间的蛋白质-蛋白质相互作用（IC50 = 239 nM）。了解更多

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IQ 3

Catalog No. A16036
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JNK3 抑制剂

IQ 3是一种选择性JNK3抑制剂（JNK3，JNK1和JNK2的Kd值分别为66、240和290 nM）。抑制THP1-Blue细胞中的NF-kB/AP1转录活性（IC50 = 1.4μM）。在体外也抑制TNF-α和IL-6的产生。了解更多

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AEG 3482

Catalog No. A11281
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JNK 抑制剂

AEG 3482是Jun激酶（JNK）依赖性细胞凋亡的小分子抑制剂。了解更多

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JNK-IN-7

Catalog No. A15136
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JNK 抑制剂

JNK-IN-7是一种相对选择性的JNKs抑制剂（对于JNK1/2/3，IC50 = 1.54/1.99/0.75 nM）；也绑定到IRAK1，PIK3C3，PIP5K3和PIP4K2C。了解更多

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DB07268

Catalog No. A15061
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JNK1 抑制剂

DB07268是一种有效的选择性JNK1抑制剂，IC50值为9 nM。了解更多

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CC-401 hydrochloride

Catalog No. A15037
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JNK 抑制剂

CC-401 hydrochloride是具有潜在抗肿瘤活性的第二代ATP竞争性蒽并吡喃酮c-Jun N末端激酶（JNK）抑制剂。了解更多

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CEP-1347

Catalog No. A13565
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JNK 抑制剂

CEP-1347是c-jun N末端激酶（JNK）信号传导的抑制剂。它可以挽救经历凋亡的运动神经元（EC50 = 20 nM）。了解更多

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CC-930 (Tanzisertib)

Catalog No. A13564
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JNK 抑制剂

CC-930在蛋白底物c-Jun的JNK依赖性磷酸化中与ATP动力学竞争，并且对JNK的所有同工型均有效（Ki（JNK1）= 44±3 nM，IC50（JNK1）= 61 nM，Ki（JNK2 ）= 6.2±0.6 nM，IC50（JNK2）= 5 nM，IC50（JNK3）= 5 nM），对MAP激酶ERK1和p38a具有选择性，IC50分别为0.48和3.4μM。了解更多

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BI-78D3

Catalog No. A13683
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JNK 抑制剂

BI-78D3是一种竞争性JNK（c-Jun N端激酶）抑制剂（IC50 = 280 nM），其选择性是p38α的100倍以上，在mTOR和PI-3K上无活性。 BI 78D3抑制JIP1（JNK相互作用蛋白1）JNK结合（IC50 = 500 nM）。了解更多

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JNK-IN-8

Catalog No. A12749
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JNK 抑制剂

JNK-IN-8是第一种JNK1，JNK2和JNK4不可逆JNK抑制剂，IC50分别为4.7 nM，18.7 nM和1 nM。了解更多

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- Mark P Roberto, .et al. Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis, Immunity, 2021, Aug 10;54(8):1807-1824.e14 PMID: 34380064
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CC-401

Catalog No. A11352
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JNK 抑制剂

CC-401是具有潜在抗肿瘤活性的第二代ATP竞争性蒽并吡喃酮c-Jun N末端激酶（JNK）抑制剂。了解更多

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- Jacob Insua-Rodr??guez, .et al. Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis, EMBO Mol Med, 2018, Oct; 10(10): e9003 PMID: 30190333
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AS 602801 (Bentamapimod)

Catalog No. A11296
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JNK 抑制剂

AS 602801 (Bentamapimod)是一种新型口服活性Jun激酶抑制剂。了解更多

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- Shuai Zhang, .et al. AS602801 sensitizes glioma cells to temozolomide and vincristine by blocking gap junction communication between glioma cells and astrocytes, J Cell Mol Med, 2021, Apr;25(8):4062-4072 PMID: 33609076
- Kuramoto K, .et al. AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes, Anticancer Res, 2018, Sep;38(9):5093-5099 PMID: 30194154
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SP600125

Catalog No. A10860
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JNK 抑制剂

SP600125是一种JNK抑制剂，对于JNK-1和JNK-2，IC50 = 40 nM，对于JNK-3，IC50 = 90 nM。了解更多

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- Tetsuya Kouno, .et al. Selective PPARδ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway, J Biol Chem, 2022, Jul;298(7):102056 PMID: 35605662
- Mark P Roberto, .et al. Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis, Immunity, 2021, Aug 10;54(8):1807-1824.e14 PMID: 34380064
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
- Yuki Haga, .et al. Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines, PLoS One, 2017, 12(3): e0174153 PMID: 28323861
- Jia-Shiuan Tsai, .et al. Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability, PLoS One, 2016, 11(1): e0147011 PMID: 26751215
- Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007