PARP

Inhibitory Selectivity

Catalog No.	Inhibitor Name	PARP	PARP1	PARP2	PARP3	V-PARP	Tankyrase-1
A10111	Olaparib		***	****			*
A10026	Veliparib		***	***
A14182	Rucaparib	****
A11243	Talazoparib	****
A10046	AG-14361		***
A10475	INO-1001	**
A10019	A-966492		****	****
A15215	PJ34	***
A12665	PJ34 HCl	***
A11026	Niraparib		***	****	*	**	**
A12750	UPF 1069		*	**
A14309	ME0328		*		**
A14371	Benzamide	*
A15375	NU1025	**
A10164	Iniparib
A12393	AZD2461
A16344	BGP-15
A10045	AG-014699 (Rucaparib)	****
A15370	4-HQN	*
A15371	BYK 204165		*	*
A15372	BYK 49187		*	*
A15374	EB 47		**
A15373	DR 2313		*	**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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DR 2313

Catalog No. A15373
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PARP 抑制剂

DR 2313是一种水溶性嘧啶酮化合物，起PARP（聚（ADP-核糖）聚合酶）抑制剂的作用。了解更多

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BYK 49187

Catalog No. A15372
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PARP-1/PARP-2 抑制剂

BYK 49187，PARP-1和PARP-2抑制剂（无细胞重组PARP-1和鼠PARP-2的pIC50值分别为8.36和7.50）。了解更多

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MK-4827 (Niraparib)

Catalog No. A11026
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PARP 抑制剂

MK-4827 (Niraparib)是一种新型有效的口服生物可利用的PARP-1和PARP-2抑制剂。了解更多

Product Citations (5)

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- Joseph M Gozgit, .et al. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity, Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612
- Ann-Katrin Hopp, .et al. Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation, Molecular cell, 2021, Jan 21; 81(2): 340?C354 PMID: 33450210
- Bian C, .et al. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression, Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937
- Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446
- Khalid Hilmi, .et al. CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair, Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323
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UPF 1069

Catalog No. A12750
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PARP2 抑制剂

UPF 1069是一种选择性聚（ADP-核糖）聚合酶（PARP）2抑制剂（PARP-2和PARP-1的IC50值分别为0.3和8.0μM）。了解更多

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