PARP
Catalog No. | Inhibitor Name | PARP | PARP1 | PARP2 | PARP3 | V-PARP | Tankyrase-1 |
---|---|---|---|---|---|---|---|
A10111 | Olaparib | *** | **** | * | |||
A10026 | Veliparib | *** | *** | ||||
A14182 | Rucaparib | **** | |||||
A11243 | Talazoparib | **** | |||||
A10046 | AG-14361 | *** | |||||
A10475 | INO-1001 | ** | |||||
A10019 | A-966492 | **** | **** | ||||
A15215 | PJ34 | *** | |||||
A12665 | PJ34 HCl | *** | |||||
A11026 | Niraparib | *** | **** | * | ** | ** | |
A12750 | UPF 1069 | * | ** | ||||
A14309 | ME0328 | * | ** | ||||
A14371 | Benzamide | * | |||||
A15375 | NU1025 | ** | |||||
A10164 | Iniparib | ||||||
A12393 | AZD2461 | ||||||
A16344 | BGP-15 | ||||||
A10045 | AG-014699 (Rucaparib) | **** | |||||
A15370 | 4-HQN | * | |||||
A15371 | BYK 204165 | * | * | ||||
A15372 | BYK 49187 | * | * | ||||
A15374 | EB 47 | ** | |||||
A15373 | DR 2313 | * | ** |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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NU 1025
Catalog No. A15375 -
4-HQN
Catalog No. A15370 -
Olaparib (AZD2281)
Catalog No. A10111 PARP 抑制剂Olaparib (AZD2281)是聚ADP核糖聚合酶(PARP)的抑制剂,该酶是一种与DNA修复有关的酶。 了解更多 -
PJ 34 hydrochloride
Catalog No. A12665 PARP 抑制剂PJ 34 hydrochloride是聚(ADP-核糖)聚合酶(PARP)(EC50 = 20 nM)的有效抑制剂。 了解更多 -
3-Aminobenzamide
Catalog No. A10475 PARP 抑制剂3-Aminobenzamide是一种新型PARP抑制剂,已知它通过抑制DNA损伤的修复使细胞在体外对辐射敏感。 了解更多 -
PJ34
Catalog No. A15215 -
AG-014699 (Rucaparib)
Catalog No. A10045 PARP 抑制剂AG-014699 (Rucaparib)是一种PARP抑制剂,可抑制聚(ADP-核糖)聚合酶(PARP,后者是DNA修复中的关键酶。 无细胞试验中作用于PARP1的Ki为1.4 nM,对其余8个PARP位点也有结合亲和力。 了解更多 -
AZD-2461
Catalog No. A12393 -
ABT-888 (Veliparib)
Catalog No. A10026 PARP 抑制剂ABT-888 (Veliparib)是一种潜在的抗癌药物,可作为PARP抑制剂。 了解更多 -
BMN-673 8R,9S
Catalog No. A15024