renin-angiotensin-aldosterone system (RAAS)
Catalog No. | Inhibitor Name | AT1 receptor | AT2 receptor | ACE | Renin | RAAS |
---|---|---|---|---|---|---|
A11123 | Aliskiren Hemifumarate | *** | ||||
A10175 | Candesartan | **** | ||||
A10351 | Enalaprilat Dihydrate | *** | *** | **** | ||
A10477 | Irbesartan | *** | ||||
A13201 | PD123319 | * | ||||
A10710 | Perindopril Erbumine | *** | ||||
A10176 | Candesartan Cilexetil | **** | ||||
A10778 | Ramipril | ** | ||||
A11738 | Captopril | * | ||||
A16420 | Azilsartan Medoxomil | ** | ||||
A13747 | Eprosartan Mesylate | **** | ||||
A11775 | Azilsartan | ** | ||||
A10905 | Telmisartan | |||||
A10123 | Benazepril HCl | |||||
A10350 | Enalapril Maleate | |||||
A11615 | Olmesartan Medoxomil | |||||
A11747 | Cilazapril Monohydrate | |||||
A11876 | Lisinopril | |||||
A11745 | Moexipril HCl | |||||
A11749 | Temocapril | |||||
A11736 | Quinapril HCl | |||||
A14206 | LCZ696 | |||||
A11748 | Fosinopril Sodium |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Zofenopril calcium
Catalog No. A12769 -
H-Val-Pro-Pro-OH
Catalog No. A18868 ACE inhibitorH-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. 了解更多 -
Fosinopril sodium
Catalog No. A11748 -
Zofenopril
Catalog No. A13615 ACE inhibitorZofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM. 了解更多 -
Lisinopril
Catalog No. A21064 angiotensin-converting enzyme inhibitorLisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. 了解更多 -
Imidaprilate
Catalog No. A20003 ACE inhibitorImidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease. 了解更多 -
MLN-4760
Catalog No. A16884 -
Spinorphin
Catalog No. A15314 -
VTP-27999 2,2,2-trifluoroacetate
Catalog No. A15281 -
Aliskiren hemifumarate
Catalog No. A11123 -
Benazepril HCl
Catalog No. A10123 -
Clinofibrate
Catalog No. A11184 HMG-CoA Reductase 抑制剂Clinofibrate是一种脂质清除剂,似乎可以改变脂质代谢,减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)(羟甲基戊二酰辅酶A还原酶),IC50为0.47 mM。 了解更多 -
Rosuvastatin
Catalog No. A11122 -
Aliskiren (CGP 60536)
Catalog No. A11616 -
Cilazapril monohydrate
Catalog No. A11747 -
Enalapril maleate
Catalog No. A10350 -
Enalaprilat dihydrate
Catalog No. A10351 -
LCZ696 (Valsartan)
Catalog No. A14206 angiotensin receptor-neprilysin 抑制剂LCZ696 (Valsartan)是一种生物利用型双效血管紧张素受体-中性溶血素抑制剂(ARNi),用于治疗高血压和心力衰竭。 了解更多 -
Captopril disulfide
Catalog No. A13521 LTA4 hydrolase 抑制剂Captopril disulfide是LTA4水解酶的可逆竞争性抑制剂(IC50 = 11 M)。Captopril已被证明是血管紧张素转化酶-1(ACE1)的一种,而不是ACE2(IC50 = 22 nM)。 了解更多