renin-angiotensin-aldosterone system (RAAS)
Catalog No. | Inhibitor Name | AT1 receptor | AT2 receptor | ACE | Renin | RAAS |
---|---|---|---|---|---|---|
A11123 | Aliskiren Hemifumarate | *** | ||||
A10175 | Candesartan | **** | ||||
A10351 | Enalaprilat Dihydrate | *** | *** | **** | ||
A10477 | Irbesartan | *** | ||||
A13201 | PD123319 | * | ||||
A10710 | Perindopril Erbumine | *** | ||||
A10176 | Candesartan Cilexetil | **** | ||||
A10778 | Ramipril | ** | ||||
A11738 | Captopril | * | ||||
A16420 | Azilsartan Medoxomil | ** | ||||
A13747 | Eprosartan Mesylate | **** | ||||
A11775 | Azilsartan | ** | ||||
A10905 | Telmisartan | |||||
A10123 | Benazepril HCl | |||||
A10350 | Enalapril Maleate | |||||
A11615 | Olmesartan Medoxomil | |||||
A11747 | Cilazapril Monohydrate | |||||
A11876 | Lisinopril | |||||
A11745 | Moexipril HCl | |||||
A11749 | Temocapril | |||||
A11736 | Quinapril HCl | |||||
A14206 | LCZ696 | |||||
A11748 | Fosinopril Sodium |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Enalaprilat dihydrate
Catalog No. A10351 -
PD 123319 ditrifluoroacetate
Catalog No. A13201 angiotensin AT2 receptor 拮抗剂PD 123319 ditrifluoroacetate是一种有效的,选择性的非肽血管紧张素AT2受体拮抗剂。大鼠肾上腺组织和大脑的IC50值分别为34和210 nM。 了解更多 -
LCZ696 (Valsartan)
Catalog No. A14206 angiotensin receptor-neprilysin 抑制剂LCZ696 (Valsartan)是一种生物利用型双效血管紧张素受体-中性溶血素抑制剂(ARNi),用于治疗高血压和心力衰竭。 了解更多 -
Captopril disulfide
Catalog No. A13521 LTA4 hydrolase 抑制剂Captopril disulfide是LTA4水解酶的可逆竞争性抑制剂(IC50 = 11 M)。Captopril已被证明是血管紧张素转化酶-1(ACE1)的一种,而不是ACE2(IC50 = 22 nM)。 了解更多 -
Angiotensin I (human, mouse, rat)
Catalog No. A14859 Angiotensin I (human,mouse,rat)是由肾素对血管紧张素原的作用形成的。 了解更多 -
Angiotensin (1-7)
Catalog No. A14862 Angiotensin (1-7)是一种内源性肽片段,可以分别通过内切肽酶或羧肽酶从Ang I或Ang II产生。 了解更多 -
Angiotensin II
Catalog No. A14863 Angiotensin II是一种八肽激素,在心血管稳态中起着核心作用。 了解更多 -
Angiotensin III (human, mouse)
Catalog No. A14864 Angiotensin III (human,mouse)是在血管紧张素II的N末端裂解形成的六肽,血管紧张素II是位于红细胞和大多数组织血管床中的血管紧张素酶在肾素-血管紧张素-醛固酮(RAAS)系统中的关键因素。 了解更多 -
Angiotensin 1/2 (1-9)
Catalog No. A14873 Angiotensin 1/2 (1-9)是一种肽(ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS),包含从血管紧张素I/II肽转换而来的氨基酸1-9。 了解更多 -
Acetyl Angiotensinogen (1-14), porcine
Catalog No. A14883 Acetyl Angiotensinogen (1-14), porcine血管紧张素原基因编码的蛋白质被称为血管紧张素原或血管紧张素原的前体。 了解更多 -
Angiotensin 1/2 (1-5)
Catalog No. A14886 Angiotensin 1/2 (1-5)是一种包含氨基酸1-5的肽,是从血管紧张素I/II转化而来的。 了解更多