CXCR

Inhibitory Selectivity

Catalog No.	Inhibitor Name	CXCR1	CXCR2	CXCR4	Other
A10913	Plerixafor 8HCl			**	CXCL12-mediated chemotaxis
A13074	Plerixafor			**	CXCL12-mediated chemotaxis
A12588	WZ811			****
A14209	SB225002		***
A16351	ATI-2341			*
A14997	AMD-070 HCl			***
A15234	SCH 563705	****	***
A14209	SB225002		***
A11555	SCH-527123 (Navarixin)	**	***
A12383	Reparixin	****	**		CXCL8
A12596	MSX-122			***
A11315	AMD 070			***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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SCH 563705

Catalog No. A15234
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CXCR2/CXCR1 拮抗剂

SCH 563705是有效的双重CXCR2（IC50 = 1.3 nM)/CXCR1（IC50 = 7.3 nM）拮抗剂。了解更多

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SCH-527123 (Navarixin)

Catalog No. A11555
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CXCR1/CXCR2 拮抗剂

SCH-527123 (Navarixin)是人CXCR1和CXCR2受体的强效选择性拮抗剂，IC50分别为42 nM和3 nM。了解更多

Product Citations (3)

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- Ruijie Zhang, .et al. Combined inhibition of IL-6 and IL-8 pathways suppresses ovarian cancer cell viability and migration and tumor growth, Int J Oncol, 2022, May;60(5):50 PMID: 35315502
- Fu S, .et al. Inhibition of interleukin 8/C-X-C chemokine receptor 1,/2 signaling reduces malignant features in human pancreatic cancer cells, Int J Oncol, 2018, Jul;53(1):349-357 PMID: 29749433
- Fu S, .et al. Blocking Interleukin-6 and Interleukin-8 Signaling Inhibits Cell Viability, Colony-forming Activity, and Cell Migration in Human Triple-negative Breast Cancer and Pancreatic Cancer Cells, Anticancer Res, 2018, Nov;38(11):6271-6279 PMID: 30396947
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Reparixin

Catalog No. A12383
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CXCL8/CXCR1/2 抑制剂

Reparixin是两种CXCL8受体CXCR1/2的有效抑制剂，它抑制CXCR2介导的细胞迁移（IC50 = 100 nM），而它强烈地阻断CXCR1介导的趋化性（IC50 = 1 nM）。了解更多

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- Naour AL, .et al. Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors, J Mol Cell Biol, 2019, Sep 3 PMID: 31504643
- Wigenstam E, .et al. N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury, Toxicology, 2015, Feb 3;328:40-7 PMID: 25497111
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Reparixin L-lysine salt

Catalog No. A15219
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CXCL8 receptor 抑制剂

Reparixin L-lysine salt是CXCL8受体的抑制剂，也抑制CXCR1和CXCR2的活化，已显示在各种损伤模型中减弱了炎症反应。了解更多

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