CXCR

Inhibitory Selectivity

Catalog No.	Inhibitor Name	CXCR1	CXCR2	CXCR4	Other
A10913	Plerixafor 8HCl			**	CXCL12-mediated chemotaxis
A13074	Plerixafor			**	CXCL12-mediated chemotaxis
A12588	WZ811			****
A14209	SB225002		***
A16351	ATI-2341			*
A14997	AMD-070 HCl			***
A15234	SCH 563705	****	***
A14209	SB225002		***
A11555	SCH-527123 (Navarixin)	**	***
A12383	Reparixin	****	**		CXCL8
A12596	MSX-122			***
A11315	AMD 070			***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Quick View
Reparixin

Catalog No. A12383
Quick View

添加到收藏
CXCL8/CXCR1/2 抑制剂

Reparixin是两种CXCL8受体CXCR1/2的有效抑制剂，它抑制CXCR2介导的细胞迁移（IC50 = 100 nM），而它强烈地阻断CXCR1介导的趋化性（IC50 = 1 nM）。了解更多

Product Citations (2)

Bulk Inquiry
- Naour AL, .et al. Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors, J Mol Cell Biol, 2019, Sep 3 PMID: 31504643
- Wigenstam E, .et al. N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury, Toxicology, 2015, Feb 3;328:40-7 PMID: 25497111
Quick View
MSX-122

Catalog No. A12596
Quick View

添加到收藏
CXCR4 抑制剂

MSX-122是口服可生物利用的CXCR4抑制剂（IC50 =?10 nM），具有潜在的抗肿瘤和抗病毒活性。CXCR4抑制剂MSX-122与趋化因子受体CXCR4结合，阻止基质衍生因子-1（SDF-1）与CXCR4受体和受体激活结合，这可能导致肿瘤细胞增殖和迁移减少。了解更多

Bulk Inquiry Free Sample
Quick View
Reparixin L-lysine salt

Catalog No. A15219
Quick View

添加到收藏
CXCL8 receptor 抑制剂

Reparixin L-lysine salt是CXCL8受体的抑制剂，也抑制CXCR1和CXCR2的活化，已显示在各种损伤模型中减弱了炎症反应。了解更多

Bulk Inquiry