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￥ 0.00 ALK
| Catalog No. | Inhibitor Name | ALK | Other |
|---|---|---|---|
| A10712 | Crizotinib | * | c-Met |
| A10662 | TAE684 | ** | |
| A11134 | Alectinib | ** | INSR,KDR |
| A13238 | Ceritinib | **** | Insulin Receptor,IGF-1R,STK22D |
| A11948 | AP26113 | *** | FER,ROS/ROS1,FLT3 |
| A11175 | GSK1838705A | *** | Insulin Receptor,IGF-1R,RSK1 |
| A13065 | AZD3463 | *** | |
| A11773 | ASP3026 | * | |
| A14207 | PF-06463922 | **** | LTK (TYK1),FER,FES (FPS) |
| A15801 | Entrectinib | TrkC,TrkB,TrkA | |
| A13450 | Brigatinib (AP26113) | **** | FLT3,IGF1R,EGFR(C797S/del19) |
| A13744 | CEP-28122 | **** | |
| A15511 | KRCA-0008 | *** | Ack1 |
| A15543 | CEP-37440 | ** | FAK |
| A16267 | HG-14-10-04 | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
37 个项目
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LDK378 (Ceritinib) dihydrochloride
Catalog No. A15142 ALK 抑制剂LDK378 (Ceritinib) dihydrochloride是有效的抗ALK抑制剂，IC50为0.2 nM，对IGF-1R和InsR的选择性分别为40倍和35倍。 了解更多 -
Entrectinib
Catalog No. A15801 TRK, ROS1, ALK 抑制剂Entrectinib，也称为RXDX-101和NMS-E628，是TrkA，TrkB和TrkC以及ROS1和ALK的小分子抑制剂，具有很高的效力和选择性。 了解更多 -
Brigatinib (AP26113)
Catalog No. A13450 ALK 抑制剂Brigatinib (AP26113)是一种有效的选择性ALK（IC50，0.6 nM）和ROS1（IC50，0.9 nM）抑制剂。它还以较低的效力抑制ROS1，FLT3和FLT3（D835Y）和EGFR的突变体。 了解更多 -
LDN-214117
Catalog No. A16096 -
Crizotinib hydrochloride
Catalog No. A16245 c-Met/NPM-ALK 抑制剂Crizotinib hydrochloride是c-Met激酶和NPM-ALK的抑制剂。 了解更多 -
Duocarmycin GA
Catalog No. A18546 DNA alkylating agentDuocarmycin GA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-drug resistant cell lines. 了解更多 -
Alectinib Hydrochloride
Catalog No. A18000 ALK inhibitorAlectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. 了解更多 -
Belizatinib
Catalog No. A20919 ALK/TRKA/TRKB/TRKC inhibitorBelizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7?nM for wild-type recombinant ALK kinase. 了解更多 -
Ensartinib hydrochloride
Catalog No. A21719 ALK/MET inhibitorEnsartinib hydrochloride (X-396 hydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. 了解更多 -
PF-2341066 (Crizotinib)
Catalog No. A10712 ALK/ c-Met 抑制剂PF-2341066 (Crizotinib)是c-Met激酶和NPM-ALK的抑制剂。PF-2341066抑制ALK阳性ALCL细胞中的细胞增殖（IC50 = 30 nM）。 了解更多 -
GSK1838705A
Catalog No. A11175 IGF-1R 抑制剂GSK1838705A是一种小分子激酶抑制剂，其抑制IGF-IR和胰岛素受体的IC50分别为2.0和1.6 nmol/L。 了解更多 -
ASP3026
Catalog No. A11773 -
ALK-IN-1 (Brigatinib analog, AP26113 analog)
Catalog No. A11948 ALK 抑制剂AP26113是一种有效的，选择性的ALK抑制剂，对野生型的功效为0.62 nM，对包括crizotinib耐药的L1196M系在内的多种突变体的活性也很强。在一组EML4-ALK或NPM-ALK阳性细胞系中，AP26113的IC50值为4-31 nM。 了解更多 -
CEP-28122
Catalog No. A13744 -
EW-7197 (Vactosertib)
Catalog No. A14213 ALK4/ALK5 抑制剂EW-7197是一种高效，选择性可生物利用的TGF-βI受体ALK4/ALK5抑制剂，IC50分别为13 nM和11 nM。 了解更多 -
PF-06463922
Catalog No. A14207 ALK 抑制剂PF-06463922是一种有效的双重ALK/ROS1抑制剂，对ROS1，ALK（WT）和ALK（L1196M）的Ki分别为<0.02 nM，<0.07 nM和0.7 nM。 了解更多 -
WZ4003
Catalog No. A14312 -
A 77-01
Catalog No. A14436
37 个项目
每页