ALK

Inhibitory Selectivity

Catalog No.	Inhibitor Name	ALK	Other
A10712	Crizotinib	*	c-Met
A10662	TAE684	**
A11134	Alectinib	**	INSR,KDR
A13238	Ceritinib	****	Insulin Receptor,IGF-1R,STK22D
A11948	AP26113	***	FER,ROS/ROS1,FLT3
A11175	GSK1838705A	***	Insulin Receptor,IGF-1R,RSK1
A13065	AZD3463	***
A11773	ASP3026	*
A14207	PF-06463922	****	LTK (TYK1),FER,FES (FPS)
A15801	Entrectinib		TrkC,TrkB,TrkA
A13450	Brigatinib (AP26113)	****	FLT3,IGF1R,EGFR(C797S/del19)
A13744	CEP-28122	****
A15511	KRCA-0008	***	Ack1
A15543	CEP-37440	**	FAK
A16267	HG-14-10-04	***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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CEP-37440

Catalog No. A15543
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FAK/ALK 抑制剂

CEP-37440是一种新型的高效选择性FAK/ALK双重抑制剂，IC50为2.3 nM（FAK）和120 nM（ALK细胞在50％人血浆中的IC50。了解更多

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