Src

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Src	Lck	Fyn	Lyn	Yes	Other
A10290	Dasatinib	****					Abl,c-Kit (D816V),c-Kit (wt)
A10108	Saracatinib	***	***	**	***		EGFR (L861Q),c-YES,EGFR (L858R)
A10161	Bosutinib	****					Abl
A11177	KX2-391	**
A10661	NVP-BHG712	*					EphB4,C-Raf,c-Abl
A12723	PP2	***	***	***			EGFR
A12724	PP1	***	***	**			Kit,EGFR,Bcr-Abl
A15518	SU6656	*		*	*	*
A16320	Dasatinib Monohydrate	****					Abl ,c-Kit (D816V),c-Kit (wt)
A14117	WH-4-023	****	****
A10766	Quercetin						Sirtuin,PKC,PI3Kγ
A11288	A-770041		*
A12417	MLR 1023				**
A13232	1-NA-PP1	****		****			c-Abl, CDK2, CAMK II
A13415	MCB-613	***	****		****
A13819	TG 100801	****		****			VEGFR1, VEGFR2, FGFR1
A13820	TG 100572	****		****			VEGFR1, VEGFR2, FGFR1
A13868	PD 166285						FGFR1, PDGFRβ, Wee1
A16241	AZM475271	****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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XL-228

Catalog No. A13069
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IGF-1R, Aurora, FGFR, ABL, SRC 抑制剂

XL228是靶向IGF1R，AURORA激酶，FGFR1-3，ABL和SRC家族激酶的蛋白激酶抑制剂。XL228是一种Aurora A抑制剂（IC50，f3 nmol/L），对ABL1（Ki，5 nmol/L）以及BCR-ABL1 T315I（Ki，1.4 nmol/L）激酶显示出有效的生化活性。了解更多

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