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Epigenetic Reader Domain

Epigenetic Reader Domain

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Epigenetic Reader Domain
A12729	(*)-JQ1	***
A11783	I-BET151	*
A12545	PFI-1	**
A11440	I-BET-762	***
A13956	RVX-208	*
A13227	SGC-CBP30	****
A13163	Bromosporine	****
A13890	OTX015	****
A12948	UNC1215	**
A13717	UNC669	*
A14133	GSK1324726A	***
A13749	MS436	**
A13068	CPI-203	***
A13957	PFI-3

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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PF-4

Catalog No. A13451
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BRPF1 bromodomain 抑制剂

PFI-4是一种有效的，选择性的且细胞可渗透的BRPF1溴结构域抑制剂（IC50 = 80 nM）。相对于包括BRPF2（BRD1），BRPF3和BRD4在内的其他溴结构域，BRPF1的选择性> 100倍。了解更多

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GSK6853

Catalog No. A16330
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BRPF1 bromodomain 抑制剂

GSK6853是BRPF1溴结构域的有效和选择性抑制剂。与所有其他溴结构域相比，它显示出优异的BRPF1效能（pKd 9.5）和大于1600倍的选择性。了解更多

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OF-1

Catalog No. A16000
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BRPF1B/BRPF2 bromodomain 抑制剂

OF-1是BRPF溴结构域的化学探针。OF-1已显示以100 nM的KD（ITC）结合到BRPF1B，以500 nM的KD（ITC）结合到BRPF2和以2.4 uM的KD（ITC）结合到BRPF3。了解更多

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GSK 5959

Catalog No. A16092
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BRPF1 bromodomain 抑制剂

GSK 5959是一种有效的，选择性的且可透过细胞的BRPF1溴结构域抑制剂，IC50?80 nM。在35个其他溴结构域（包括BRPF2/3和BET家族溴结构域）中，对BRPF1的选择性超过100倍。了解更多

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