FLT3

Inhibitory Selectivity

Catalog No.	Inhibitor Name	FLT3	Other
A10996	Cabozantinib	**	VEGFR2/KDR,c-Met,Kit
A10027	Quizartinib	***
A11411	Dovitinib	****	c-Kit,VEGFR3/FLT4,FGFR1
A10610	Amuvatinib	*	c-Kit (D816H),PDGFRα (V561D)
A10887	Tandutinib	*	c-Kit,PDGFRβ,CSF-1R
A11180	TG101209	*	JAK2,RET,JAK3
A10508	KW-2449	****	Abl (T315I),Abl,FGFR1
A10352	ENMD-2076	***	RET,Aurora A,VEGFR3/FLT4
A10198	Dovitinib Dilactic Acid	****	c-Kit,FGFR1,VEGFR3/FLT4
A12694	Pacritinib	**	JAK2 (V617F),JAK2,TYK2
A12427	TCS 359	*
A10352	ENMD-2076 L-(*)-Tartaric acid		RET,Aurora A,VEGFR3/FLT4
A15904	UNC2025	****	Mer
A14025	AMG 925	****	CDK4,CDK1
A14214	G-749	****	Mer,Aurora B,RET
A14156	AZD2932		PDGFRβ,VEGFR-2,c-Kit
A10769	R406		Syk
A12419	Go6976		JAK2,PKCα,PKCβ1
A11962	TG-02 (SB1317)	*	CDK2, JAK2
A14411	Gilteritinib (ASP2215)	****	Axl
A15003	AST 487		Ret, c-Kit, KDR, c-Abl
A15520	Pexidartinib (PLX3397)	*	Kit, CSF-1R
A15548	SU5614
A16248	BPR1J-097	**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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AST 487

Catalog No. A15003
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RET kinase 抑制剂

AST487是Ret激酶抑制剂/FLT3抑制剂，对Ret的IC50为0.88 uM。了解更多

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TG101209

Catalog No. A11180
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JAK2 抑制剂

TG101209是一种新型的JAK2抑制剂，无细胞试验中IC50为6 nM，对Flt3和RET作用效果稍弱，IC50分别为25 nM和17 nM，作用于JAK2比作用于JAK3选择性高30倍左右，对JAK2V617F和MPLW515L/K突变型敏感。在多发性骨髓瘤中具有显着的体外活性，并且对CD45+骨髓瘤细胞显示出优先的细胞毒性。了解更多

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