FLT3

Inhibitory Selectivity

Catalog No.	Inhibitor Name	FLT3	Other
A10996	Cabozantinib	**	VEGFR2/KDR,c-Met,Kit
A10027	Quizartinib	***
A11411	Dovitinib	****	c-Kit,VEGFR3/FLT4,FGFR1
A10610	Amuvatinib	*	c-Kit (D816H),PDGFRα (V561D)
A10887	Tandutinib	*	c-Kit,PDGFRβ,CSF-1R
A11180	TG101209	*	JAK2,RET,JAK3
A10508	KW-2449	****	Abl (T315I),Abl,FGFR1
A10352	ENMD-2076	***	RET,Aurora A,VEGFR3/FLT4
A10198	Dovitinib Dilactic Acid	****	c-Kit,FGFR1,VEGFR3/FLT4
A12694	Pacritinib	**	JAK2 (V617F),JAK2,TYK2
A12427	TCS 359	*
A10352	ENMD-2076 L-(*)-Tartaric acid		RET,Aurora A,VEGFR3/FLT4
A15904	UNC2025	****	Mer
A14025	AMG 925	****	CDK4,CDK1
A14214	G-749	****	Mer,Aurora B,RET
A14156	AZD2932		PDGFRβ,VEGFR-2,c-Kit
A10769	R406		Syk
A12419	Go6976		JAK2,PKCα,PKCβ1
A11962	TG-02 (SB1317)	*	CDK2, JAK2
A14411	Gilteritinib (ASP2215)	****	Axl
A15003	AST 487		Ret, c-Kit, KDR, c-Abl
A15520	Pexidartinib (PLX3397)	*	Kit, CSF-1R
A15548	SU5614
A16248	BPR1J-097	**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Dovitinib (TKI-258)

Catalog No. A11411
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RTK 抑制剂

Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂，可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞，IC50值分别为150 nM和90 nM。了解更多

Product Citations (1)

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- Yunping Hu, .et al. FGFR1/MAPK-directed brachyury activation drives PD-L1-mediated immune evasion to promote lung cancer progression, Cancer Lett, 2022, Oct 28;547:215867 PMID: 35985510
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Pexidartinib (PLX3397)

Catalog No. A15520
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CSF1/Kit/FLT3 抑制剂

Pexidartinib (PLX3397)是KIT，CSF1R和FLT3的小分子酪氨酸激酶（RTK）抑制剂，具有潜在的抗肿瘤活性。了解更多

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- Lu Luo, .et al. Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NF κB/NLRP3 signaling pathway in cerebral ischemic mice, J Neuroinflammation, 2022, Jun 11;19(1):141 PMID: 35690810
- Sarah R Anderson,, .et al. Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence, bioRxiv, 2022, 01.05.475126
- Hannah D Mason, .et al. Glia limitans superficialis oxidation and breakdown promotes cortical cell death after repeat head injury, JCI Insight, 2021, Oct 8;6(19):e149229 PMID: 34428178
- Chritica Lodder, .et al. CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia, Acta Neuropathol Commun, 2021, Jun 8;9(1):108 PMID: 34103079
- Anderson SR, .et al. Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia, Cell Rep, 2019, May 14;27(7):2002-2013.e5 PMID: 31091440
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Tandutinib (MLN518)

Catalog No. A10887
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FLT3 抑制剂

Tandutinib (MLN518)是一种有效的FLT3抑制剂，c-KIT和PDGF受体酪氨酸激酶的自磷酸化，从而抑制细胞增殖并诱导细胞凋亡。了解更多

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AC710 Mesylate

Catalog No. A16246
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FLT3/KIT/PDGFRα/PDGFRβ 抑制剂

AC710 Mesylate是一种有效的选择性PDGFR家族激酶抑制剂，对于FLT3/KIT/PDGFRα/PDGFRβ的Kd值分别为0.6 nM/1.0 nM/1.3 nM/1.0 nM。了解更多

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Dovitinib Dilactic acid (TKI258 Dilactic acid)

Catalog No. A10198
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RTK 抑制剂

Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂，可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞，IC50值分别为150 nM和90 nM。了解更多

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