FLT3

Inhibitory Selectivity

Catalog No.	Inhibitor Name	FLT3	Other
A10996	Cabozantinib	**	VEGFR2/KDR,c-Met,Kit
A10027	Quizartinib	***
A11411	Dovitinib	****	c-Kit,VEGFR3/FLT4,FGFR1
A10610	Amuvatinib	*	c-Kit (D816H),PDGFRα (V561D)
A10887	Tandutinib	*	c-Kit,PDGFRβ,CSF-1R
A11180	TG101209	*	JAK2,RET,JAK3
A10508	KW-2449	****	Abl (T315I),Abl,FGFR1
A10352	ENMD-2076	***	RET,Aurora A,VEGFR3/FLT4
A10198	Dovitinib Dilactic Acid	****	c-Kit,FGFR1,VEGFR3/FLT4
A12694	Pacritinib	**	JAK2 (V617F),JAK2,TYK2
A12427	TCS 359	*
A10352	ENMD-2076 L-(*)-Tartaric acid		RET,Aurora A,VEGFR3/FLT4
A15904	UNC2025	****	Mer
A14025	AMG 925	****	CDK4,CDK1
A14214	G-749	****	Mer,Aurora B,RET
A14156	AZD2932		PDGFRβ,VEGFR-2,c-Kit
A10769	R406		Syk
A12419	Go6976		JAK2,PKCα,PKCβ1
A11962	TG-02 (SB1317)	*	CDK2, JAK2
A14411	Gilteritinib (ASP2215)	****	Axl
A15003	AST 487		Ret, c-Kit, KDR, c-Abl
A15520	Pexidartinib (PLX3397)	*	Kit, CSF-1R
A15548	SU5614
A16248	BPR1J-097	**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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R406 besylate

Catalog No. A10769
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Syk 抑制剂

R406 besylate是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。了解更多

Product Citations (1)

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- Gabriella Leung, .et al. ARPC1B binds WASP to control actin polymerization and curtail tonic signaling in B cells, JCI insight, 2021, Dec 8;6(23):e149376 PMID: 34673575