MEK
Catalog No. | Inhibitor Name | MEK | MEK1 | MEK1/2 | MEK2 | MEK5 | Other |
---|---|---|---|---|---|---|---|
A10257 | Selumetinib | *** | |||||
A10256 | PD0325901 | **** | |||||
A11029 | Trametinib | **** | **** | ||||
A10957 | U0126-EtOH | * | ** | MKK6/p38 MAPK,MKK3/p38 MAPK | |||
A10212 | PD184352 | ** | ** | ||||
A10705 | PD98059 | * | |||||
A10151 | BIX 02189 | **** | ERK5,TGFβR1 | ||||
A10089 | Pimasertib | * | |||||
A10150 | BIX 02188 | *** | ERK5,TGFβR1 | ||||
A11040 | TAK-733 | **** | |||||
A10115 | AZD8330 | ERK phosphorylation | |||||
A11493 | Binimetinib | *** | *** | ||||
A14137 | SL-327 | * | * | AP-1,MKK3/p38 MAPK | |||
A11264 | Refametinib | ** | ** | ||||
A12974 | GDC-0623 | **** | |||||
A15762 | BI-847325 | ** | *** | Aurora B,Aurora C,Aurora A | |||
A11441 | Cobimetinib | *** | |||||
A10704 | PD318088 | ||||||
A10453 | Honokiol | Akt-phosphorylation | |||||
A11247 | RO4927350 | ||||||
A13272 | RO4987655 | **** | |||||
A14019 | RO5126766 (CH5126766) | * | BRAF, CRAF |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
-
U0126-EtOH
Catalog No. A10957 MEK 抑制剂U0126-EtOH是MEK1和MEK2的抑制剂,IC50分别为72 nM和58 nM。 了解更多 -
Refametinib
Catalog No. A11264 -
PD 198306
Catalog No. A16032 -
AZD6244 (Selumetinib)
Catalog No. A10257 MEK 抑制剂Selumetinib (AZD6244)是一种有效,高选择性的MEK抑制剂,ARRY142886,AZD-6244和ARRY-142886是MEK 1/2抑制剂,GI50值在14至50 nm之间。 了解更多 -
Refametinib (RDEA-119, BAY 86-9766)
Catalog No. A12866 MEK1/2 抑制剂Refametinib (RDEA-119,BAY 86-9766)是一种口服生物利用型选择性MEK抑制剂,EC50为 2.0-15 nM。具有潜在的抗肿瘤活性。 了解更多 -
MEK162 (ARRY-438162, Binimetinib)
Catalog No. A11493 MEK1/2 抑制剂MEK162 (ARRY-438162,Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。 了解更多 -
Cobimetinib (racemate)
Catalog No. A15050 -
G-479
Catalog No. A14380 -
GSK1120212 (JTP-74057, Trametinib)
Catalog No. A11029 MEK 抑制剂GSK1120212 (JTP-74057,Trametinib)强烈阻止了MEK1和MEK2激酶的活性,而不是其他98种激酶的活性。 了解更多 -
Cobimetinib (R-enantiomer)
Catalog No. A15051 MEK 抑制剂Cobimetinib R-enantiomer是Cobimetinib的R对映异构体,Cobimetinib是一种有力的,高选择性的促分裂原活化蛋白激酶(MEK1/2)抑制剂。 了解更多 -
AS703026 (Pimasertib)
Catalog No. A10089 MEK1/2 抑制剂AS703026 (Pimasertib)是一种新型的,选择性的,口服可生物利用的MEK1/2抑制剂,可抑制MM细胞的生长和存活以及细胞因子诱导的破骨细胞分化。 了解更多 -
PD184352 (CI-1040)
Catalog No. A10212 MEK1/2 抑制剂PD184352 (CI-1040)是一种ATP非竞争性MEK1/2抑制剂,在基于细胞的测定中,IC50为17 nM,对MEK1/2的选择性是对MEK5的100倍。 了解更多 -
AZD8330
Catalog No. A10115