购物车 0 ￥ 0.00
微信关注
申请试用装

Raf

Inhibitory Selectivity

Catalog No.Inhibitor Name RafC-Raf/Raf-1B-RafA-rafOther
A10739Vemurafenib
*
**
SRMS,ACK1,MAP4K5 (KHS1)
A10002PLX-4720
***
***
BRK,FRK,CSK
A11381Dabrafenib
****
****
A10420GDC-0879
****
A10773RAF265
**
VEGFR2
A11063AZ 628
**
**
A10661NVP-BHG712
*
EphB4,c-Src,c-Abl
A10829SB590885
****
A11077ZM 336372
*
A10001Sorafenib
****
**
mVEGFR2(Flk1),mVEGFR3,mPDGFRβ
A11436GW5074
***
A13323TAK-632
****
***
Aurora B,PDGFRβ,FGFR3
A13772CEP-32496
**
***
RET,PDGFRβ,LCK
A13226Encorafenib
****
A14019RO5126766
*
***
MEK1
A15855PLX7904
A11240MLN2480
A10250Regorafenib (BAY 73-4506)
****
**
FGFR1, Kit, PDGFRβ, RET, Tie-2 , VEGFR1, VEGFR2, VEGFR3
A11211ML 786 dihydrochloride
****
****
Abl-1, DDR2, EPHA2, RET, PERK
A12739PF-04880594
****
****
A13525L-779450
****
p38α, GSK3β, Lck

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

44 个项目

每页

设置降序顺序
  1. Locostatin
    Quick View

    Locostatin

    Catalog No. A16079
    Quick View
    RKIP/Raf1 抑制剂
    Locostatin是Raf激酶抑制剂蛋白（RKIP/Raf1激酶相互作用的细胞渗透性强抑制剂，是细胞迁移的抑制剂。 了解更多
  2. LXH254
    Quick View

    LXH254

    Catalog No. A16841
    Quick View
    pan-RAF 抑制剂
    LXH254是II型ATP竞争性抑制剂，可在皮摩尔浓度下抑制B/C RAF激酶活性，对456种人类激酶和基于细胞的测定具有高度选择性。 了解更多
  3. Regorafenib monohydrate
    Quick View

    Regorafenib monohydrate

    Catalog No. A15218
    Quick View
    Tyrosine kinase 抑制剂
    Regorafenib monohydrate是VEGFR1/VEGFR2/VEGFR3/PDGFRβ/Kit/RET和Raf-1的多靶点抑制剂，IC50分别为13 nM/4.2 nM/46 nM/22 nM/7 nM/1.5 nM和2.5 nM。 了解更多
  4. RAF709
    Quick View

    RAF709

    Catalog No. A16842
    Quick View
    raf kinase 抑制剂
    RAF709是B/C RAF激酶的有效抑制剂，对B-RAF和C-RAF的IC50值几乎相等，为0.4 nM。它具有高选择性，在浓度为1 μM时，对BRAF, BRAFV600E和CRAF的靶向结合率大于99%，而对DDR1、DDR2、FRK和FDGFRβ的脱靶效应非常少。 了解更多
  5. Lifirafenib (BGB-283)
    Quick View

    Lifirafenib (BGB-283)

    Catalog No. A16844
    Quick View
    BRAF 抑制剂
    Lifirafenib (BGB-283)，也称为Beigene-283，在生化分析中有效抑制RAF家族激酶和EGFR活性，重组BRAFV600E激酶结构域，EGFR和EGFR T790M/L858R突变体的IC50值为23、29和495 nM。 了解更多
  6. CEP-32496
    Quick View

    CEP-32496

    Catalog No. A13772
    Quick View
    Raf 抑制剂
    CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1（B-raf）丝氨酸/苏氨酸蛋白激酶抑制剂，具有潜在的抗肿瘤活性。 了解更多
  7. AZ304
    Quick View
    • 最新产品

    AZ304

    Catalog No. A17225
    Quick View
    dual BRAF 抑制剂
    AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively. 了解更多
  8. BRAF inhibitor
    Quick View

    BRAF inhibitor

    Catalog No. A11333
    Quick View
    BRAF 抑制剂
    BRAF inhibitor是一种有效的BRAF抑制剂。 了解更多
  9. L-779450
    Quick View

    L-779450

    Catalog No. A13525
    Quick View
    Raf 抑制剂
    L-779450是有效的选择性 B-Raf 抑制剂，Kd 为 2.4 nM。是神经外伤性疾病的潜在治疗方法。 了解更多
  10. Diazepinomicin
    Quick View

    Diazepinomicin

    Catalog No. A12891
    Quick View
    RAS/RAF/MAPK 抑制剂
    Diazepinomicin，也称为TLN-4601，是具有潜在抗肿瘤活性的RAS/RAF/MAPK信号传导途径的小分子抑制剂。 了解更多
  11. PF-04880594
    Quick View

    PF-04880594

    Catalog No. A12739
    Quick View
    RAF 抑制剂
    PF-04880594是RAF抑制剂，BRAF/BRAFV599E和c-RAF的IC50值分别为0.19 nM/0.13 nM和0.39 nM。 了解更多
  12. MLN2480 (BIIB-024)
    Quick View

    MLN2480 (BIIB-024)

    Catalog No. A11240
    Quick View
    pan-Raf 抑制剂
    MLN2480 (BIIB-024)是一种口服的Raf激酶抑制剂。 了解更多
  13. GW 5074
    Quick View

    GW 5074

    Catalog No. A11436
    Quick View
    Raf-1 抑制剂
    GW 5074是一种强效、选择性和细胞渗透性的c-Raf1激酶抑制剂。 了解更多
  14. Raf265 derivative
    Quick View

    Raf265 derivative

    Catalog No. A10774
    Quick View
    RAF/VEGFR 抑制剂
    Raf265 derivative是Raf265的衍生物，Raf265是一种口服，高度选择性的RAF和VEGFR激酶抑制剂，IC50为5至10μM。 了解更多
  15. PLX-4720
    Quick View

    PLX-4720

    Catalog No. A10002
    Quick View
    Raf 抑制剂
    PLX-4720是一种有效的，选择性的B-RafV600E抑制剂，无细胞试验中IC50为13 nM，同样有效地作用于c-Raf-1(Y340D和Y341D突变型)，作用于B-RafV600E比作用于野生型B-Raf选择性高10倍。 了解更多
  16. RAF265 (CHIR-265)
    Quick View

    RAF265 (CHIR-265)

    Catalog No. A10773
    Quick View
    RAF/VEGFR 抑制剂
    RAF265 (CHIR-265)是一种口服，高度选择性的RAF和VEGFR激酶抑制剂，可控制或正常化VEGFR-2，同时抑制B-raf和c-Raf突变以预防癌症。 了解更多
  17. ZM 336372
    Quick View

    ZM 336372

    Catalog No. A11077
    Quick View
    C-Raf 抑制剂
    ZM 336372是有效的ATP Raf-1体外竞争性抑制剂 (IC50 = 70 nM)。 了解更多
  18. GDC-0879
    Quick View

    GDC-0879

    Catalog No. A10420
    Quick View
    B-Raf 抑制剂
    GDC-0879是B-Raf激酶的特异性抑制剂，靶向B-Raf (V600E) (IC50: 0.13 nM)。 了解更多
  19. SB590885
    Quick View

    SB590885

    Catalog No. A10829
    Quick View
    B-Raf 抑制剂
    SB590885是B-Raf激酶的选择性小分子抑制剂，B-Raf和c-Raf的Ki app值分别为0.16和1.72 nM。 了解更多
  20. AZ628
    Quick View

    AZ628

    Catalog No. A11063
    Quick View
    Raf 抑制剂
    AZ628是一种RAF抑制剂，IC50值：BRAF V600E和野生型CRAF约为30 nM，野生型BRAF约为100 nM。 了解更多
  21. Lifirafenib
    Quick View

    Lifirafenib

    Catalog No. A20988
    Quick View
    Raf/EGFR inhibitor
    Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. 了解更多
  22. B-Raf inhibitor 1 dihydrochloride
    Quick View

    B-Raf inhibitor 1 dihydrochloride

    Catalog No. A21834
    Quick View
    Raf kinase inhibitor
    B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. 了解更多
  23. B-Raf IN 1
    Quick View

    B-Raf IN 1

    Catalog No. A21055
    Quick View
    B-Raf kinase inhibitor
    B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. 了解更多
  24. LUT014
    Quick View

    LUT014

    Catalog No. A19449
    Quick View
    B-Raf inhibitor
    LUT014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment. Extracted from patent WO 2019026065A2 . 了解更多
  25. ERK-IN-1
    Quick View

    ERK-IN-1

    Catalog No. A19080
    Quick View
    RAF/ERK1/2 inhibitor
    ERK-IN-1 (compound B) is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. 了解更多
  26. RAF mutant-IN-1
    Quick View

    RAF mutant-IN-1

    Catalog No. A19011
    Quick View
    Raf nhibitor
    RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF340D/Y341D, B-RAFV600E and B-RAFWT, respectively. 了解更多
  27. Belvarafenib
    Quick View

    Belvarafenib

    Catalog No. A13177
    Quick View
    pan RAF inhibitor
    Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. 了解更多
  28. LY3009120
    Quick View

    LY3009120

    Catalog No. A16603
    Quick View
    pan RAF inhibitor
    LY3009120 is a pan RAF inhibitor which inhibits BRAFV600E, BRAFWT and CRAFWT with IC50s of 5.8, 9.1 and 15 nM, respectively. 了解更多
  29. Regorafenib Hydrochloride
    Quick View

    Regorafenib Hydrochloride

    Catalog No. A11546
    Quick View
    VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitor
    Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. 了解更多
  30. HG6-64-1
    Quick View

    HG6-64-1

    Catalog No. A16022
    Quick View
    B-Raf 抑制剂
    HG6-64-1是有效的选择性B-Raf和突变B-Raf抑制剂；更多信息可以在专利WO 2011090738中找到。 了解更多
  31. ML 786 dihydrochloride
    Quick View

    ML 786 dihydrochloride

    Catalog No. A11211
    Quick View
    Raf 抑制剂
    ML 786 dihydrochloride是一种有效的Raf激酶抑制剂（B-RafV600E，C-Raf和野生型B-Raf的IC50值分别为2.1、2.5和4.2 nM）。 了解更多
  32. PLX7904
    Quick View

    PLX7904

    Catalog No. A15855
    Quick View
    Raf 抑制剂
    PLX7904是有效的选择性悖论突破性RAF抑制剂。它能够有效抑制突变型BRAF黑色素瘤细胞中ERK1/2的激活，但不能过度激活突变型RAS表达细胞中的ERK1/2。 了解更多
  33. Dabrafenib Mesylate
    Quick View

    Dabrafenib Mesylate

    Catalog No. A15059
    Quick View
    Raf 抑制剂
    Dabrafenib Mesylate是一种新颖，有效和选择性的Raf激酶抑制剂，能够抑制野生型B-Raf，B-RafV600E和c-Raf的激酶活性，IC50值分别为3.2、0.8和5.0 nM。 了解更多
  34. CEP-32496 hydrochloride
    Quick View

    CEP-32496 hydrochloride

    Catalog No. A15040
    Quick View
    Raf 抑制剂
    CEP-32496 hydrochloride是野生型BRAF，V600E突变型BRAF和c-Raf的高效抑制剂，Kd值分别为14 nM，36 nM和39 nM。 了解更多
  35. B-Raf-inhibitor 1
    Quick View

    B-Raf-inhibitor 1

    Catalog No. A14122
    Quick View
    B-Raf 抑制剂
    B-Raf inhibitor 1是有效的选择性B-Raf抑制剂，对A375增殖和A375 p-ERK的细胞IC50分别为0.31 uM和2 nM。 了解更多
  36. RO5126766 (CH5126766)
    Quick View

    RO5126766 (CH5126766)

    Catalog No. A14019
    Quick View
    Raf/MEK dual 抑制剂
    RO5126766 (CH5126766)是对Raf和MEK丝裂原激活的蛋白激酶（MAPK）具有特异性的蛋白激酶抑制剂，具有潜在的抗肿瘤活性。 了解更多
  37. TAK-632
    Quick View

    TAK-632

    Catalog No. A13323
    Quick View
    pan-RAF 抑制剂
    TAK-632是一种有效的泛RAF抑制剂，具有良好的体外活性（BRAF（V600E）IC50，2.4 nM; BRAF（wt），8.3 nM; CRAF，1.4 nM; pMEK（A375）IC50，12 nM; pMEK（HMVII ），49 nM。 了解更多
  38. Balamapimod (MKI-833)
    Quick View

    Balamapimod (MKI-833)

    Catalog No. A13119
    Quick View
    Ras/Raf/MEK 抑制剂
    Balamapimod (MKI-833)是Ras/Raf/MEK抑制剂。 了解更多
  39. LGX 818 (Encorafenib)
    Quick View

    LGX 818 (Encorafenib)

    Catalog No. A13226
    Quick View
    Selective B-RAF 抑制剂
    LGX 818 (Encorafenib)是一种Raf激酶抑制剂，具有潜在的抗肿瘤活性。 了解更多
  40. Dabrafenib (GSK2118436A)
    Quick View

    Dabrafenib (GSK2118436A)

    Catalog No. A11381
    Quick View
    Raf 抑制剂
    Dabrafenib (GSK2118436A)是一种有效且选择性的B-RAF蛋白激酶抑制剂，具有V600E突变，目前正在临床试验中。 了解更多
  41. NVP-BHG712
    Quick View

    NVP-BHG712

    Catalog No. A10661
    Quick View
    EphB4 抑制剂
    NVP-BHG712是EphB4激酶的选择性抑制剂，在体外对EphB4的选择性超过40多种其他激酶（包括FGFR3）。 了解更多
  42. PLX4032 (Vemurafenib)
    Quick View

    PLX4032 (Vemurafenib)

    Catalog No. A10739
    Quick View
    Raf 抑制剂
    PLX4032(Vemurafenib)也称为RG7204，Vemurafenib，R7204，RO5185426。PLX4032是B-raf抑制剂，IC50为44 nM。 了解更多
  43. Sorafenib Tosylate (Nexavar)
    Quick View

    Sorafenib Tosylate (Nexavar)

    Catalog No. A10001
    Quick View
    Raf 抑制剂
    Sorafenib Tosylate (Nexavar)是几种酪氨酸蛋白激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂的新型小分子抑制剂，Raf-1，wt BRAF和V599E突变型BRAF的IC50为6、22、38 nM。 了解更多
  44. Regorafenib (BAY 73-4506)
    Quick View

    Regorafenib (BAY 73-4506)

    Catalog No. A10250
    Quick View
    VEGFR 抑制剂
    Regorafenib (BAY 73-4506)是一种多激酶抑制剂，IC50为17、40和69 nM c-KIT，VEGFR2，B-Raf。Regorafenib（BAY 73-4506）是一种针对肿瘤及其脉管系统的口服生物利用型多激酶抑制剂。 了解更多

44 个项目

每页

设置降序顺序
FILTER BY:

购物选项

作用机制
  1. Inhibitor (抑制剂) (44)
靶点
  1. Abl (1)
  2. Aurora B (1)
  3. B-Raf (22)
  4. BRK (1)
  5. C-Raf (Raf-1) (17)
  6. CDK2 (1)
  7. EphB4 (1)
  8. FGFR3 (1)
  9. GSK-3β (1)
  10. Kit (2)
  11. Lck (2)
  12. MEK1 (1)
  13. p38α (1)
  14. PDGFRα (1)
  15. PDGFRβ (5)
  16. Raf (3)
  17. RET (3)
  18. RKIP (1)
  19. Src (1)
  20. SRMS (1)
  21. VEGFR1 (FLT1) (2)
  22. VEGFR2 (FLK1) (4)
  23. VEGFR3 (FLT4) (2)
溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

ADOOQ 产品质量保证
Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.

立即申请
Get Code
联系我们
查看FAQs

Adooq 公司

产品订购

技术资源

地址

© 2006-2019 AdooQ BioScience （南京百鑫德诺生物科技有限公司）. All Rights Reserved.
苏ICP备14027875号
Accept Payment
Rewards