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| Catalog No. | Inhibitor Name | Raf | C-Raf/Raf-1 | B-Raf | A-raf | Other |
|---|---|---|---|---|---|---|
| A10739 | Vemurafenib | * | ** | SRMS,ACK1,MAP4K5 (KHS1) | ||
| A10002 | PLX-4720 | *** | *** | BRK,FRK,CSK | ||
| A11381 | Dabrafenib | **** | **** | |||
| A10420 | GDC-0879 | **** | ||||
| A10773 | RAF265 | ** | VEGFR2 | |||
| A11063 | AZ 628 | ** | ** | |||
| A10661 | NVP-BHG712 | * | EphB4,c-Src,c-Abl | |||
| A10829 | SB590885 | **** | ||||
| A11077 | ZM 336372 | * | ||||
| A10001 | Sorafenib | **** | ** | mVEGFR2(Flk1),mVEGFR3,mPDGFRβ | ||
| A11436 | GW5074 | *** | ||||
| A13323 | TAK-632 | **** | *** | Aurora B,PDGFRβ,FGFR3 | ||
| A13772 | CEP-32496 | ** | *** | RET,PDGFRβ,LCK | ||
| A13226 | Encorafenib | **** | ||||
| A14019 | RO5126766 | * | *** | MEK1 | ||
| A15855 | PLX7904 | |||||
| A11240 | MLN2480 | |||||
| A10250 | Regorafenib (BAY 73-4506) | **** | ** | FGFR1, Kit, PDGFRβ, RET, Tie-2 , VEGFR1, VEGFR2, VEGFR3 | ||
| A11211 | ML 786 dihydrochloride | **** | **** | Abl-1, DDR2, EPHA2, RET, PERK | ||
| A12739 | PF-04880594 | **** | **** | |||
| A13525 | L-779450 | **** | p38α, GSK3β, Lck |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
22 个项目
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B-Raf-inhibitor 1
Catalog No. A14122 B-Raf 抑制剂B-Raf inhibitor 1是有效的选择性B-Raf抑制剂，对A375增殖和A375 p-ERK的细胞IC50分别为0.31 uM和2 nM。 了解更多 -
HG6-64-1
Catalog No. A16022 -
PLX4032 (Vemurafenib)
Catalog No. A10739 Raf 抑制剂PLX4032(Vemurafenib)也称为RG7204，Vemurafenib，R7204，RO5185426。PLX4032是B-raf抑制剂，IC50为44 nM。 了解更多 -
RO5126766 (CH5126766)
Catalog No. A14019 Raf/MEK dual 抑制剂RO5126766 (CH5126766)是对Raf和MEK丝裂原激活的蛋白激酶（MAPK）具有特异性的蛋白激酶抑制剂，具有潜在的抗肿瘤活性。 了解更多 -
Dabrafenib Mesylate
Catalog No. A15059 Raf 抑制剂Dabrafenib Mesylate是一种新颖，有效和选择性的Raf激酶抑制剂，能够抑制野生型B-Raf，B-RafV600E和c-Raf的激酶活性，IC50值分别为3.2、0.8和5.0 nM。 了解更多 -
Sorafenib Tosylate (Nexavar)
Catalog No. A10001 Raf 抑制剂Sorafenib Tosylate (Nexavar)是几种酪氨酸蛋白激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂的新型小分子抑制剂，Raf-1，wt BRAF和V599E突变型BRAF的IC50为6、22、38 nM。 了解更多 -
LGX 818 (Encorafenib)
Catalog No. A13226 Selective B-RAF 抑制剂LGX 818 (Encorafenib)是一种Raf激酶抑制剂，具有潜在的抗肿瘤活性。 了解更多 -
Dabrafenib (GSK2118436A)
Catalog No. A11381 Raf 抑制剂Dabrafenib (GSK2118436A)是一种有效且选择性的B-RAF蛋白激酶抑制剂，具有V600E突变，目前正在临床试验中。 了解更多 -
ML 786 dihydrochloride
Catalog No. A11211 Raf 抑制剂ML 786 dihydrochloride是一种有效的Raf激酶抑制剂（B-RafV600E，C-Raf和野生型B-Raf的IC50值分别为2.1、2.5和4.2 nM）。 了解更多 -
CEP-32496 hydrochloride
Catalog No. A15040 Raf 抑制剂CEP-32496 hydrochloride是野生型BRAF，V600E突变型BRAF和c-Raf的高效抑制剂，Kd值分别为14 nM，36 nM和39 nM。 了解更多 -
GDC-0879
Catalog No. A10420 -
PF-04880594
Catalog No. A12739 -
Raf265 derivative
Catalog No. A10774 RAF/VEGFR 抑制剂Raf265 derivative是Raf265的衍生物，Raf265是一种口服，高度选择性的RAF和VEGFR激酶抑制剂，IC50为5至10μM。 了解更多 -
AZ628
Catalog No. A11063 -
Lifirafenib (BGB-283)
Catalog No. A16844 BRAF 抑制剂Lifirafenib (BGB-283)，也称为Beigene-283，在生化分析中有效抑制RAF家族激酶和EGFR活性，重组BRAFV600E激酶结构域，EGFR和EGFR T790M/L858R突变体的IC50值为23、29和495 nM。 了解更多 -
RAF265 (CHIR-265)
Catalog No. A10773 RAF/VEGFR 抑制剂RAF265 (CHIR-265)是一种口服，高度选择性的RAF和VEGFR激酶抑制剂，可控制或正常化VEGFR-2，同时抑制B-raf和c-Raf突变以预防癌症。 了解更多 -
SB590885
Catalog No. A10829 -
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最新产品
AZ304
Catalog No. A17225 dual BRAF 抑制剂AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively. 了解更多 -
22 个项目
每页