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￥ 0.00 γ-Secretase
| Catalog No. | Inhibitor Name | γ secretase | Aβ | Notch | Other |
|---|---|---|---|---|---|
| A10288 | DAPT (GSI-IX) | * | |||
| A10802 | RO4929097 | *** | *** | Aβ40 | |
| A10836 | Semagacestat | ** | ** | ||
| A10157 | Avagacestat | **** | |||
| A11174 | Dibenzazepine | *** | *** | ||
| A11176 | LY411575 | **** | **** | ||
| A15899 | L-685458 | * | |||
| A13815 | FLI-06 | * | |||
| A13319 | PF-03084014 | ** | |||
| A11194 | MK-0752 | *** | Aβ40 | ||
| A13544 | LY3039478 | **** | |||
| A16152 | IMR-1 | * | |||
| A16223 | IMR-1A | * | |||
| A11258 | Begacestat (GSI-953) | ** | |||
| A12444 | BMS 299897 | ||||
| A13217 | TC-E 5006 | * | |||
| A15304 | MRK 560 | **** | |||
| A15301 | JLK 6 | ||||
| A16214 | CHF5074 | * | |||
| A16215 | Z-Ile-Leu-aldehyde |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
46 个项目
每页
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PF-03084014
Catalog No. A11259 -
Flurbiprofen Axetil
Catalog No. A13662 -
L-685458
Catalog No. A15899 -
Begacestat (GSI-953)
Catalog No. A11258 -
gamma-secretase modulator 1
Catalog No. A11425 Gamma-secretase modulatorgamma-secretase modulator 1是γ-分泌酶调节剂，γ-分泌酶调节剂1可用于阿尔茨海默病。 了解更多 -
gamma-secretase modulator 2
Catalog No. A11427 -
TC-E 5006
Catalog No. A13217 -
Verubecestat (MK-8931)
Catalog No. A16113 β-secretase/BACE1 抑制剂Verubecestat (MK-8931)是一种有效的选择性β-分泌酶抑制剂，是BACE1蛋白抑制剂或Beta-site APP裂解酶1抑制剂。 了解更多 -
CHF5074
Catalog No. A16214 -
Z-Ile-Leu-aldehyde
Catalog No. A16215 -
BACE1-IN-4
Catalog No. A18462 BACE1 inhibitorBACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer??s disease. 了解更多 -
PF-06751979
Catalog No. A20066 BACE1 inhibitorPF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. 了解更多 -
Umibecestat (CNP520)
Catalog No. A18987 BACE-1 inhibitorUmibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. 了解更多 -
Lanabecestat
Catalog No. A12282 BACE1 inhibitorLanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多 -
BACE1-IN-1
Catalog No. A12183 BACE1 inhibitorBACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. 了解更多 -
BMS-906024
Catalog No. A21172 gamma secretase inhibitorBMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. 了解更多 -
Compound E
Catalog No. A21292 -
β-Secretase Inhibitor IV
Catalog No. A21346 BACE-1 inhibitorβ-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. 了解更多 -
AZD3839 free base
Catalog No. A21606 BACE1 inhibitorAZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多 -
JLK 6
Catalog No. A15301 -
Compound W
Catalog No. A15296 -
gamma-secretase modulator 3
Catalog No. A15090 -
Timosaponin b-II
Catalog No. A14591 -
BMS-708163 (Avagacestat)
Catalog No. A10157 Gamma-secretase 抑制剂BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。 了解更多 -
DAPT (GSI-IX)
Catalog No. A10288 Gamma secretase 抑制剂DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。 了解更多 -
Semagacestat (LY450139)
Catalog No. A10836 Gamma-secretase 抑制剂Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。 了解更多 -
LY2811376
Catalog No. A11776 -
IMR-1A
Catalog No. A16223 -
BMS 433796
Catalog No. A11337 -
E 2012
Catalog No. A11393 -
BMS 299897
Catalog No. A12444 γ-secretase 抑制剂BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。 了解更多 -
Flurizan
Catalog No. A12433 -
LY3039478
Catalog No. A13544
46 个项目
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