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￥ 0.00 γ-Secretase
| Catalog No. | Inhibitor Name | γ secretase | Aβ | Notch | Other |
|---|---|---|---|---|---|
| A10288 | DAPT (GSI-IX) | * | |||
| A10802 | RO4929097 | *** | *** | Aβ40 | |
| A10836 | Semagacestat | ** | ** | ||
| A10157 | Avagacestat | **** | |||
| A11174 | Dibenzazepine | *** | *** | ||
| A11176 | LY411575 | **** | **** | ||
| A15899 | L-685458 | * | |||
| A13815 | FLI-06 | * | |||
| A13319 | PF-03084014 | ** | |||
| A11194 | MK-0752 | *** | Aβ40 | ||
| A13544 | LY3039478 | **** | |||
| A16152 | IMR-1 | * | |||
| A16223 | IMR-1A | * | |||
| A11258 | Begacestat (GSI-953) | ** | |||
| A12444 | BMS 299897 | ||||
| A13217 | TC-E 5006 | * | |||
| A15304 | MRK 560 | **** | |||
| A15301 | JLK 6 | ||||
| A16214 | CHF5074 | * | |||
| A16215 | Z-Ile-Leu-aldehyde |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
34 个项目
每页
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Compound E
Catalog No. A21292 -
BMS-906024
Catalog No. A21172 gamma secretase inhibitorBMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. 了解更多 -
IMR-1A
Catalog No. A16223 -
Z-Ile-Leu-aldehyde
Catalog No. A16215 -
CHF5074
Catalog No. A16214 -
TC-E 5006
Catalog No. A13217 -
gamma-secretase modulator 2
Catalog No. A11427 -
gamma-secretase modulator 1
Catalog No. A11425 Gamma-secretase modulatorgamma-secretase modulator 1是γ-分泌酶调节剂，γ-分泌酶调节剂1可用于阿尔茨海默病。 了解更多 -
Begacestat (GSI-953)
Catalog No. A11258 -
L-685458
Catalog No. A15899 -
Flurbiprofen Axetil
Catalog No. A13662 -
PF-03084014
Catalog No. A11259 -
JLK 6
Catalog No. A15301 -
BMS-708163 (Avagacestat)
Catalog No. A10157 Gamma-secretase 抑制剂BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。 了解更多 -
DAPT (GSI-IX)
Catalog No. A10288 Gamma secretase 抑制剂DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。 了解更多 -
Semagacestat (LY450139)
Catalog No. A10836 Gamma-secretase 抑制剂Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。 了解更多 -
LY2811376
Catalog No. A11776 -
BMS 433796
Catalog No. A11337 -
E 2012
Catalog No. A11393 -
BMS 299897
Catalog No. A12444 γ-secretase 抑制剂BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。 了解更多 -
Flurizan
Catalog No. A12433 -
LY3039478
Catalog No. A13544 -
gamma-secretase modulator 3
Catalog No. A15090 -
Compound W
Catalog No. A15296
34 个项目
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