购物车 0 ￥ 0.00
微信关注
申请试用装

p38-MAPK

Inhibitory Selectivity

Catalog No.Inhibitor Name p38 MAPKp38αp38βOther
A10824SB203580
*
PKB
A10148Doramapimod
****
A10823SB202190
**
**
A10545LY2228820
****
A10982VX-702
***
A11078PH-797804
***
*
A10983VX-745
***
*
A11582TAK-715
****
*
A11562SB239063
**
**
A12526Losmapimod
***
***
A11321Skepinone-L
****
A10895Pexmetinib
Tie-2
A10970AMG 548
****
***
A11221PD 169316
**
A11563 SD-06
*
A12408ML-3043
*
IL-1β, TNF-α
A12770Talmapimod (SCIO-469)
***
A13551Pamapimod (R-1503)
***
*
A13552RWJ 67657
*
*
A13563BMS-582949
***
A13678SB-242235
***
A16015AL 8697
****
A16035SX 011
***
A16038JX 401
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

43 个项目

每页

设置降序顺序
  1. CMPD-1
    Quick View

    CMPD-1

    Catalog No. A16040
    Quick View
    p38 MAPK 抑制剂
    CMPD-1是p38α介导的MK2a（促分裂原激活的蛋白激酶2a）磷酸化（表观Ki = 330 nM）的非ATP竞争性选择性抑制剂。 了解更多
  2. TA-01
    Quick View

    TA-01

    Catalog No. A16236
    Quick View
    CK 抑制剂
    TA-01有效抑制CK1ε，CK1δ和p38α（IC50值分别为6.4、6.8和6.7 nM）。 了解更多
  3. MW-150
    Quick View

    MW-150

    Catalog No. A18798
    Quick View
    p38α MAPK inhibitor
    MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. 了解更多
  4. Dilmapimod
    Quick View

    Dilmapimod

    Catalog No. A13553
    Quick View
    p38 MAPK 抑制剂
    Dilmapimod是p38 MAPK抑制剂。 了解更多
  5. TA-02
    Quick View

    TA-02

    Catalog No. A13644
    Quick View
    p38 MAPK inhibitor
    TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. 了解更多
  6. Pamapimod (R-1503)
    Quick View

    Pamapimod (R-1503)

    Catalog No. A13551
    Quick View
    p38 MAPK 抑制剂
    Pamapimod (R-1503)是一种新型p38丝裂原活化蛋白激酶抑制剂。 了解更多
  7. FR 167653 free base
    Quick View

    FR 167653 free base

    Catalog No. A21110
    Quick View
    p38 MAPK inhibitor
    FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. 了解更多
  8. Losmapimod (GW856553X)
    Quick View

    Losmapimod (GW856553X)

    Catalog No. A12526
    Quick View
    p38 MAPK 抑制剂
    Losmapimod，也称为GW856553或GW856553X，是葛兰素史克（GlaxoSmithKline）开发的药物，可作为酶家族的选择性抑制剂，称为p38促分裂原活化蛋白激酶，其作用于p38α和p38β的pKi分别为8.1和7.6 。 了解更多
  9. ML-3043
    Quick View

    ML-3043

    Catalog No. A12408
    Quick View
    p38 MAPK 抑制剂
    ML-3043是p38 MAPK抑制剂（IC50 = 0.38μM）。在外周血单核细胞（PBMC）分析中抑制IL-1β和TNF-α的释放（IC50值分别为0.039和0.16μM）。 了解更多
  10. Talmapimod (SCIO-469)
    Quick View

    Talmapimod (SCIO-469)

    Catalog No. A12770
    Quick View
    p38 MAPK 抑制剂
    Talmapimod (SCIO-469)是一种具有ATP竞争性的选择性p38抑制剂（体外p38α的IC50 = 9 nM）。 了解更多
  11. SB 203580 hydrochloride
    Quick View

    SB 203580 hydrochloride

    Catalog No. A21526
    Quick View
    p38 MAPK inhibitor
    SB 203580 hydrochloride (RWJ 64809 hydrochloride) is a widely used p38 MAPK inhibitor. 了解更多
  12. SB 239063
    Quick View

    SB 239063

    Catalog No. A11562
    Quick View
    p38 MAPK 抑制剂
    SB 239063是一种强效选择性p38 MAPKα/β抑制剂(p38α的IC50=44 nM)。SB 239063对ERK, JNK1和其他激酶的选择性超过220倍；比SB 203580的选择性高约3倍。SB 239063减少炎症细胞因子的产生，并在体内口服后具有神经保护作用。 了解更多
  13. Asiaticoside
    Quick View

    Asiaticoside

    Catalog No. A12021
    Quick View
    Asiaticoside是植物积雪草的活性化学成分。积雪草苷用于研究伤口和烧伤的潜在治疗方法。 了解更多
  14. MW-150 hydrochloride
    Quick View

    MW-150 hydrochloride

    Catalog No. A21854
    Quick View
    p38α MAPK inhibitor
    MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. 了解更多
  15. PD 169316
    Quick View

    PD 169316

    Catalog No. A11221
    Quick View
    p38 MAPK 抑制剂
    PD 169316 (PD169316)是p38 MAPK.1的选择性抑制剂，可抑制p38 MAPK，IC50为89 nM。 了解更多
  16. Asiatic acid
    Quick View

    Asiatic acid

    Catalog No. A10092
    Quick View
    Anti-inflammatory agent
    Asiatic acid常用于伤口愈合。亚洲酸具有抗氧化，抗炎和神经保护的特性。积雪草酸衍生物的合成可用作抗癌剂；糖原磷酸化酶抑制剂；保肝剂。 了解更多
  17. MW-150 dihydrochloride dihydrate
    Quick View

    MW-150 dihydrochloride dihydrate

    Catalog No. A21860
    Quick View
    p38α MAPK inhibitor
    MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. 了解更多
  18. VX-745
    Quick View

    VX-745

    Catalog No. A10983
    Quick View
    p38 MAPK 抑制剂
    VX-745是一种有效的，选择性p38α抑制剂，IC50为10 nM，比作用于p38β选择性高22倍，对p38γ没有抑制作用。 了解更多
  19. BMS-582949 hydrochloride
    Quick View

    BMS-582949 hydrochloride

    Catalog No. A21914
    Quick View
    p38α MAPK inhibitor
    BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC50 of 13 nM. 了解更多
  20. LY2228820 (Ralimetinib)
    Quick View

    LY2228820 (Ralimetinib)

    Catalog No. A10545
    Quick View
    p38 MAPK 抑制剂
    LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。 了解更多
  21. Ralimetinib
    Quick View

    Ralimetinib

    Catalog No. A21942
    Quick View
    p38 MAPK α/β inhibitor
    Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. 了解更多
  22. p38-α MAPK-IN-1
    Quick View

    p38-α MAPK-IN-1

    Catalog No. A21036
    Quick View
    MAPK14 inhibitor
    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. 了解更多
  23. MAPK13-IN-1
    Quick View

    MAPK13-IN-1

    Catalog No. A21038
    Quick View
    MAPK13 (p38??) inhibitor
    MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. 了解更多
  24. DBM 1285 dihydrochloride
    Quick View

    DBM 1285 dihydrochloride

    Catalog No. A16058
    Quick View
    p38 MAPK 抑制剂
    DBM 1285 dihydrochloride是p38 MAPK抑制剂。在巨噬细胞和体内抑制p38磷酸化和LPS诱导的TNF-α产生。 了解更多
  25. SB 706504
    Quick View

    SB 706504

    Catalog No. A16055
    Quick View
    p38 MAPK 抑制剂
    SB 706504是p38 MAPK抑制剂，可防止LPS诱导的慢性阻塞性肺疾病单核细胞衍生巨噬细胞中一系列趋化因子和细胞因子的转录。 了解更多
  26. JX 401
    Quick View

    JX 401

    Catalog No. A16038
    Quick View
    P38 MAPK 抑制剂
    JX 401是MAP激酶p38α亚型的有效可逆抑制剂（IC50 = 32 nM）。 了解更多
  27. EO 1428
    Quick View

    EO 1428

    Catalog No. A16037
    Quick View
    P38 MAPK 抑制剂
    EO 1428是合成的4-氨基二苯甲酮小分子，已在针对p38 MAP激酶抑制剂的优化研究中确定。 了解更多
  28. SX 011
    Quick View

    SX 011

    Catalog No. A16035
    Quick View
    P38 MAPK 抑制剂
    SX 011是选择性的p38α，p38β和JNK-2抑制剂。在p38γ，p38δ，ERK-2和JNK-1处无明显活性。 了解更多
  29. AL 8697
    Quick View

    AL 8697

    Catalog No. A16015
    Quick View
    p38 MAPK 抑制剂
    AL-8697是一种选择性p38 MAPK（促分裂原活化蛋白激酶）抑制剂，也称为P38α抑制剂。它具有抑制P38 MAPK活性的功能。 了解更多
  30. SD-06
    Quick View

    SD-06

    Catalog No. A11563
    Quick View
    p38 MAPK 抑制剂
    SD-06是p38 MAP激酶抑制剂；抑制p38α的IC50值为170 nM，并抑制LPS刺激的大鼠TNF释放（1mg/kg，口服时83％抑制）。 了解更多
  31. SKF 86002 Dihydrochloride
    Quick View

    SKF 86002 Dihydrochloride

    Catalog No. A11101
    Quick View
    p38 MAPK 抑制剂
    SKF 86002 Dihydrochloride是p38 MAP激酶的抑制剂（IC50 = 0.1-1 uM）。有效抑制人单核细胞中LPS诱导的IL-1和TNF-α的产生（IC50 = 1 uM）。 了解更多
  32. AMG 548
    Quick View

    AMG 548

    Catalog No. A10970
    Quick View
    p38 MAPK 抑制剂
    AMG 548是有效的p38α选择性抑制剂。它对其他36种激酶表现出> 1000倍的选择性，并且抑制全血LPS刺激的TNFα。 了解更多
  33. Pexmetinib (ARRY-614)
    Quick View

    Pexmetinib (ARRY-614)

    Catalog No. A10895
    p38 MAPK 抑制剂
    Pexmetinib (ARRY-614)是通过双重抑制p38促分裂原活化蛋白激酶（MAPK）和Tie2/Tek受体酪氨酸激酶，其在HEK-293细胞中的IC50分别为4 nM/18 nM。Pexmetinib是一种有效的细胞因子合成抑制剂。 了解更多
  34. BMS-582949
    Quick View

    BMS-582949

    Catalog No. A13563
    Quick View
    p38 MAPK 抑制剂
    BMS-582949是一种双重作用p38激酶抑制剂，非常适合于避免增加细胞p38活化的耐药机制。 了解更多
  35. RWJ-67657
    Quick View

    RWJ-67657

    Catalog No. A13552
    Quick View
    p38 MAPK 抑制剂
    RWJ-67657是有效的p38 MAPK抑制剂。 了解更多
  36. SB-242235
    Quick View

    SB-242235

    Catalog No. A13678
    Quick View
    p38 MAPK 抑制剂
    SB-242235是一种有效的选择性p38 MAP激酶抑制剂，可能是细胞因子介导的疾病（例如自身免疫或炎性疾病）的有效疗法。 了解更多
  37. TAK-715
    Quick View

    TAK-715

    Catalog No. A11582
    Quick View
    p38 MAPK 抑制剂
    TAK 715是p38 MAPK抑制剂（p38MAPKα的IC50 = 7.1 nM），Wnt /β-catenin信号传导抑制剂，并抑制22种激酶（包括CK1δ/ε）超过80％。 了解更多
  38. Skepinone-L
    Quick View

    Skepinone-L

    Catalog No. A11321
    Quick View
    p38 MAPK 抑制剂
    Skepinone-L是选择性p38丝裂原活化蛋白激酶抑制剂。 了解更多
  39. PH-797804
    Quick View

    PH-797804

    Catalog No. A11078
    Quick View
    p38 MAPK 抑制剂
    PH-797804是p38丝裂原活化蛋白（MAP）激酶的二芳基吡啶酮抑制剂。 了解更多
  40. VX-702
    Quick View

    VX-702

    Catalog No. A10982
    Quick View
    p38 MAPK 抑制剂
    VX-702是一种高选择性p38α MAPK抑制剂，可抑制血小板激动剂诱导的p38激活（IC50 = 4至20 nM）。 了解更多
  41. SB 202190
    Quick View

    SB 202190

    Catalog No. A10823
    Quick View
    p38 MAPK 抑制剂
    SB202190是p38 MAP激酶的高度选择性，有效和细胞渗透性抑制剂。 了解更多
  42. Doramapimod (BIRB-796)
    Quick View

    Doramapimod (BIRB-796)

    Catalog No. A10148
    Quick View
    p38 MAPK 抑制剂
    Doramapimod（BIRB 796）是p38 MAPK的小分子抑制剂，在调节促炎细胞因子的产生中起关键作用。 了解更多
  43. SB 203580
    Quick View

    SB 203580

    Catalog No. A10824
    Quick View
    p38 MAPK 抑制剂
    SB 203580是p38α和p38β的特异性抑制剂，可抑制MAPKAP激酶2和热激蛋白27的下游激活。 了解更多

43 个项目

每页

设置降序顺序
FILTER BY:

购物选项

作用机制
  1. Inhibitor (抑制剂) (41)
溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

ADOOQ 产品质量保证
Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.

立即申请
Get Code
联系我们
查看FAQs

Adooq 公司

产品订购

技术资源

地址

© 2006-2019 AdooQ BioScience （南京百鑫德诺生物科技有限公司）. All Rights Reserved.
苏ICP备14027875号
Accept Payment
Rewards