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p38-MAPK

Inhibitory Selectivity

Catalog No.Inhibitor Name p38 MAPKp38αp38βOther
A10824SB203580
*
PKB
A10148Doramapimod
****
A10823SB202190
**
**
A10545LY2228820
****
A10982VX-702
***
A11078PH-797804
***
*
A10983VX-745
***
*
A11582TAK-715
****
*
A11562SB239063
**
**
A12526Losmapimod
***
***
A11321Skepinone-L
****
A10895Pexmetinib
Tie-2
A10970AMG 548
****
***
A11221PD 169316
**
A11563 SD-06
*
A12408ML-3043
*
IL-1β, TNF-α
A12770Talmapimod (SCIO-469)
***
A13551Pamapimod (R-1503)
***
*
A13552RWJ 67657
*
*
A13563BMS-582949
***
A13678SB-242235
***
A16015AL 8697
****
A16035SX 011
***
A16038JX 401
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

41 个项目

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  1. CMPD-1
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    CMPD-1

    Catalog No. A16040
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    p38 MAPK 抑制剂
    CMPD-1是p38α介导的MK2a（促分裂原激活的蛋白激酶2a）磷酸化（表观Ki = 330 nM）的非ATP竞争性选择性抑制剂。 了解更多
  2. TA-01
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    TA-01

    Catalog No. A16236
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    CK 抑制剂
    TA-01有效抑制CK1ε，CK1δ和p38α（IC50值分别为6.4、6.8和6.7 nM）。 了解更多
  3. MW-150
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    MW-150

    Catalog No. A18798
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    p38α MAPK inhibitor
    MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. 了解更多
  4. Dilmapimod
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    Dilmapimod

    Catalog No. A13553
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    p38 MAPK 抑制剂
    Dilmapimod是p38 MAPK抑制剂。 了解更多
  5. TA-02
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    TA-02

    Catalog No. A13644
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    p38 MAPK inhibitor
    TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. 了解更多
  6. Pamapimod (R-1503)
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    Pamapimod (R-1503)

    Catalog No. A13551
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    p38 MAPK 抑制剂
    Pamapimod (R-1503)是一种新型p38丝裂原活化蛋白激酶抑制剂。 了解更多
  7. FR 167653 free base
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    FR 167653 free base

    Catalog No. A21110
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    p38 MAPK inhibitor
    FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. 了解更多
  8. Losmapimod (GW856553X)
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    Losmapimod (GW856553X)

    Catalog No. A12526
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    p38 MAPK 抑制剂
    Losmapimod，也称为GW856553或GW856553X，是葛兰素史克（GlaxoSmithKline）开发的药物，可作为酶家族的选择性抑制剂，称为p38促分裂原活化蛋白激酶，其作用于p38α和p38β的pKi分别为8.1和7.6 。 了解更多
  9. ML-3043
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    ML-3043

    Catalog No. A12408
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    p38 MAPK 抑制剂
    ML-3043是p38 MAPK抑制剂（IC50 = 0.38μM）。在外周血单核细胞（PBMC）分析中抑制IL-1β和TNF-α的释放（IC50值分别为0.039和0.16μM）。 了解更多
  10. Talmapimod (SCIO-469)
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    Talmapimod (SCIO-469)

    Catalog No. A12770
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    p38 MAPK 抑制剂
    Talmapimod (SCIO-469)是一种具有ATP竞争性的选择性p38抑制剂（体外p38α的IC50 = 9 nM）。 了解更多
  11. SB 203580 hydrochloride
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    SB 203580 hydrochloride

    Catalog No. A21526
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    p38 MAPK inhibitor
    SB 203580 hydrochloride (RWJ 64809 hydrochloride) is a widely used p38 MAPK inhibitor. 了解更多
  12. SB 239063
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    SB 239063

    Catalog No. A11562
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    p38 MAPK 抑制剂
    SB 239063是一种强效选择性p38 MAPKα/β抑制剂(p38α的IC50=44 nM)。SB 239063对ERK, JNK1和其他激酶的选择性超过220倍；比SB 203580的选择性高约3倍。SB 239063减少炎症细胞因子的产生，并在体内口服后具有神经保护作用。 了解更多
  13. MW-150 hydrochloride
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    MW-150 hydrochloride

    Catalog No. A21854
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    p38α MAPK inhibitor
    MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. 了解更多
  14. PD 169316
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    PD 169316

    Catalog No. A11221
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    p38 MAPK 抑制剂
    PD 169316 (PD169316)是p38 MAPK.1的选择性抑制剂，可抑制p38 MAPK，IC50为89 nM。 了解更多
  15. MW-150 dihydrochloride dihydrate
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    MW-150 dihydrochloride dihydrate

    Catalog No. A21860
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    p38α MAPK inhibitor
    MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. 了解更多
  16. VX-745
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    VX-745

    Catalog No. A10983
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    p38 MAPK 抑制剂
    VX-745是一种有效的，选择性p38α抑制剂，IC50为10 nM，比作用于p38β选择性高22倍，对p38γ没有抑制作用。 了解更多
  17. BMS-582949 hydrochloride
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    BMS-582949 hydrochloride

    Catalog No. A21914
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    p38α MAPK inhibitor
    BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC50 of 13 nM. 了解更多
  18. LY2228820 (Ralimetinib)
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    LY2228820 (Ralimetinib)

    Catalog No. A10545
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    p38 MAPK 抑制剂
    LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。 了解更多
  19. Ralimetinib
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    Ralimetinib

    Catalog No. A21942
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    p38 MAPK α/β inhibitor
    Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. 了解更多
  20. p38-α MAPK-IN-1
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    p38-α MAPK-IN-1

    Catalog No. A21036
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    MAPK14 inhibitor
    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. 了解更多
  21. MAPK13-IN-1
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    MAPK13-IN-1

    Catalog No. A21038
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    MAPK13 (p38??) inhibitor
    MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. 了解更多
  22. DBM 1285 dihydrochloride
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    DBM 1285 dihydrochloride

    Catalog No. A16058
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    p38 MAPK 抑制剂
    DBM 1285 dihydrochloride是p38 MAPK抑制剂。在巨噬细胞和体内抑制p38磷酸化和LPS诱导的TNF-α产生。 了解更多
  23. SB 706504
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    SB 706504

    Catalog No. A16055
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    p38 MAPK 抑制剂
    SB 706504是p38 MAPK抑制剂，可防止LPS诱导的慢性阻塞性肺疾病单核细胞衍生巨噬细胞中一系列趋化因子和细胞因子的转录。 了解更多
  24. JX 401
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    JX 401

    Catalog No. A16038
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    P38 MAPK 抑制剂
    JX 401是MAP激酶p38α亚型的有效可逆抑制剂（IC50 = 32 nM）。 了解更多
  25. EO 1428
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    EO 1428

    Catalog No. A16037
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    P38 MAPK 抑制剂
    EO 1428是合成的4-氨基二苯甲酮小分子，已在针对p38 MAP激酶抑制剂的优化研究中确定。 了解更多
  26. SX 011
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    SX 011

    Catalog No. A16035
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    P38 MAPK 抑制剂
    SX 011是选择性的p38α，p38β和JNK-2抑制剂。在p38γ，p38δ，ERK-2和JNK-1处无明显活性。 了解更多
  27. AL 8697
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    AL 8697

    Catalog No. A16015
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    p38 MAPK 抑制剂
    AL-8697是一种选择性p38 MAPK（促分裂原活化蛋白激酶）抑制剂，也称为P38α抑制剂。它具有抑制P38 MAPK活性的功能。 了解更多
  28. SD-06
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    SD-06

    Catalog No. A11563
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    p38 MAPK 抑制剂
    SD-06是p38 MAP激酶抑制剂；抑制p38α的IC50值为170 nM，并抑制LPS刺激的大鼠TNF释放（1mg/kg，口服时83％抑制）。 了解更多
  29. SKF 86002 Dihydrochloride
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    SKF 86002 Dihydrochloride

    Catalog No. A11101
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    p38 MAPK 抑制剂
    SKF 86002 Dihydrochloride是p38 MAP激酶的抑制剂（IC50 = 0.1-1 uM）。有效抑制人单核细胞中LPS诱导的IL-1和TNF-α的产生（IC50 = 1 uM）。 了解更多
  30. AMG 548
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    AMG 548

    Catalog No. A10970
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    p38 MAPK 抑制剂
    AMG 548是有效的p38α选择性抑制剂。它对其他36种激酶表现出> 1000倍的选择性，并且抑制全血LPS刺激的TNFα。 了解更多
  31. Pexmetinib (ARRY-614)
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    Pexmetinib (ARRY-614)

    Catalog No. A10895
    p38 MAPK 抑制剂
    Pexmetinib (ARRY-614)是通过双重抑制p38促分裂原活化蛋白激酶（MAPK）和Tie2/Tek受体酪氨酸激酶，其在HEK-293细胞中的IC50分别为4 nM/18 nM。Pexmetinib是一种有效的细胞因子合成抑制剂。 了解更多
  32. BMS-582949
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    BMS-582949

    Catalog No. A13563
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    p38 MAPK 抑制剂
    BMS-582949是一种双重作用p38激酶抑制剂，非常适合于避免增加细胞p38活化的耐药机制。 了解更多
  33. RWJ-67657
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    RWJ-67657

    Catalog No. A13552
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    p38 MAPK 抑制剂
    RWJ-67657是有效的p38 MAPK抑制剂。 了解更多
  34. SB-242235
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    SB-242235

    Catalog No. A13678
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    p38 MAPK 抑制剂
    SB-242235是一种有效的选择性p38 MAP激酶抑制剂，可能是细胞因子介导的疾病（例如自身免疫或炎性疾病）的有效疗法。 了解更多
  35. TAK-715
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    TAK-715

    Catalog No. A11582
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    p38 MAPK 抑制剂
    TAK 715是p38 MAPK抑制剂（p38MAPKα的IC50 = 7.1 nM），Wnt /β-catenin信号传导抑制剂，并抑制22种激酶（包括CK1δ/ε）超过80％。 了解更多
  36. Skepinone-L
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    Skepinone-L

    Catalog No. A11321
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    p38 MAPK 抑制剂
    Skepinone-L是选择性p38丝裂原活化蛋白激酶抑制剂。 了解更多
  37. PH-797804
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    PH-797804

    Catalog No. A11078
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    p38 MAPK 抑制剂
    PH-797804是p38丝裂原活化蛋白（MAP）激酶的二芳基吡啶酮抑制剂。 了解更多
  38. VX-702
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    VX-702

    Catalog No. A10982
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    p38 MAPK 抑制剂
    VX-702是一种高选择性p38α MAPK抑制剂，可抑制血小板激动剂诱导的p38激活（IC50 = 4至20 nM）。 了解更多
  39. SB 202190
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    SB 202190

    Catalog No. A10823
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    p38 MAPK 抑制剂
    SB202190是p38 MAP激酶的高度选择性，有效和细胞渗透性抑制剂。 了解更多
  40. Doramapimod (BIRB-796)
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    Doramapimod (BIRB-796)

    Catalog No. A10148
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    p38 MAPK 抑制剂
    Doramapimod（BIRB 796）是p38 MAPK的小分子抑制剂，在调节促炎细胞因子的产生中起关键作用。 了解更多
  41. SB 203580
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    SB 203580

    Catalog No. A10824
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    p38 MAPK 抑制剂
    SB 203580是p38α和p38β的特异性抑制剂，可抑制MAPKAP激酶2和热激蛋白27的下游激活。 了解更多

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