PDE

Inhibitory Selectivity

Catalog No.	Inhibitor Name	PDE	PDE1	PDE2	PDE3	PDE4	PDE5	PDE6	PDE9A	PDE10A	Other
A10804	Roflumilast					****
A10216	Cilomilast					***
A10883	Tadalafil						***
A10733	Pimobendan				**
A11073	GSK256066					****
A11191	PF-2545920									****
A10805	Rolipram					**
A10217	Cilostazol				**
A10592	Milrinone			**	**						ATPase
A12619	Avanafil						****
A10066	Aminophylline	*									adenosine receptor
A15799	TAK-063									****
A13722	Deltarasin	***
A10541	Luteolin		*	*	*	*	*
A10464	Icariin						**				mAChR,AChR
A10480	Irsogladine
A10319	Dipyridamole
A10339	Dyphylline
A11527	PF-8380	***
A10965	Vardenafil		***				****
A11019	Ibudilast (KC-404)
A11289	Apremilast (CC 10004)					***
A11326	Bay 60-7550			****
A11602	Vinpocetine										Sodium channel
A12550	Zardaverine				**	**
A12631	Sildenafil						***	***
A12776	AN2728					***
A13121	PF-04447943								***
A13467	MK-0359
A13596	Cilostamide				***
A15191	Nortadalafil
A15197	Oglemilast					****
A15198	Olprinone Hydrochloride

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Apremilast (CC 10004)

Catalog No. A11289
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PDE4 抑制剂

Apremilast (CC 10004)是一种新型的PDE4抑制剂，可抑制人类风湿性滑膜细胞自发产生肿瘤坏死因子-α，并改善实验性关节炎。了解更多

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