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HSP

Inhibitory Selectivity

Catalog No.Inhibitor Name HSP70HSP90HSP90αHSP90βHSP105Other
A10010Tanespimycin
***
A10659Luminespib
***
***
***
A10011Alvespimycin HCl
*
A11402Ganetespib
***
A10143BIIB021
****
A11062Onalespib
***
A11025Geldanamycin
*
p185
A10660NVP-BEP800
*
*
A11189SNX-2112
**
**
**
A11074PF-04929113
**
HER2
A11195KW-2478
****
A11251XL888
**
A13351VER155008
*
A13817VER-50589
***
***
A14282CH5138303
****
****
A13812VER-49009
**
**
A14292NMS-E973
***
A11130PU-H71
*
A12850HSP990
****
****
****
A14389KNK437
A11131MPC-3100
*
A11269IPI-504 (Retaspimycin HCl)
A11272IPI-493
**
A12388MKT 077
A12648CUDC-305 (DEBIO-0932 )
A16050Macbecin I
A16053TRC 051384
A16056EC 144
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. TAS-116
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    TAS-116

    Catalog No. A20987
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    HSP90??/HSP90?? inhibitor
    TAS-116 is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity. 了解更多
  2. Arimoclomol maleate
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    Arimoclomol maleate

    Catalog No. A21912
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    co-inducer of heat shock proteins (HSP)
    Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP). 了解更多
  3. HSP70-IN-1
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    HSP70-IN-1

    Catalog No. A21716
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    HSP inhibitor
    HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. 了解更多
  4. SNX-5422 Mesylate
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    SNX-5422 Mesylate

    Catalog No. A21512
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    Hsp90 inhibitor
    SNX-5422 Mesylate (PF-04929113 Mesylate), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37?nM. 了解更多
  5. Apoptozole
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    Apoptozole

    Catalog No. A21177
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    Hsc70 and Hsp70 inhibitor
    Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14?μM, respectively, and can induce apoptosis. 了解更多
  6. Retaspimycin
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    Retaspimycin

    Catalog No. A15221
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    Hsp90 inhibitor
    Retaspimycin is a potent and water-soluble inhibitor of Hsp90, with EC50s of 119 nM for both Hsp90 and Grp9. 了解更多
  7. YZ129
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    YZ129

    Catalog No. A13601
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    HSP90-calcineurin-NFAT inhibitor
    YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. 了解更多
  8. HSP27 inhibitor J2
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    HSP27 inhibitor J2

    Catalog No. A18874
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    HSP27 inhibitor
    HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. 了解更多
  9. Col003
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    Col003

    Catalog No. A18573
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    Hsp47 inhibitor
    Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix. 了解更多
  10. JG-98
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    JG-98

    Catalog No. A18734
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    Hsp70 inhibitor
    JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. 了解更多
  11. VER-49009
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    VER-49009

    Catalog No. A13812
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    Hsp90 抑制剂
    VER-49009是吡唑化合物，可抑制Hsp90，IC50值为47 nM。 了解更多
  12. CH5138303
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    CH5138303

    Catalog No. A14282
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    HSP90 抑制剂
    CH5138303是Hsp90抑制剂，Kd为0.48 nM。 了解更多
  13. NMS-E973
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    NMS-E973

    Catalog No. A14292
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    HSP90 抑制剂
    NMS-E973是一种有效的选择性Hsp90抑制剂。 了解更多
  14. Alvespimycin
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    Alvespimycin

    Catalog No. A14990
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    Hsp90 抑制剂
    Alvespimycin是一种选择性Hsp90抑制剂，GI50为53 nM。 了解更多
  15. PU-WS13
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    PU-WS13

    Catalog No. A14129
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    Grp94 抑制剂
    PU-WS13是嘌呤支架类的强效Grp94特异性Hsp90抑制剂。PU-WS13是Grp94的细胞可渗透抑制剂，EC50为220 nM。 了解更多
  16. Macbecin I
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    Macbecin I

    Catalog No. A16050
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    HSP90 抑制剂
    Macbecin I是一种安沙霉素抗生素化合物，可通过与ATP结合位点结合来抑制Hsp90活性，IC50值为μM。 了解更多
  17. Rocaglamide
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    Rocaglamide

    Catalog No. A12765
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    Heat shock reporter
    Rocaglamide是 T 细胞中一种有效的 NF-κB 活化抑制剂。Rocaglamide 是一种有效的选择性热休克因子 1 (HSF1) 活化抑制剂，IC50 约为 50 nM。Rocaglamide 还抑制翻译起始因子 eIF4A 的功能。Rocaglamide 还具有抗癌特性。 了解更多
  18. KNK437
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    KNK437

    Catalog No. A14389
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    pan-HSP 抑制剂
    KNK437剂量依赖性地抑制了COLO 320DM（人类结肠癌）细胞中耐热性的获得以及各种HSP的诱导，包括HSP105，HSP70和HSP40。 了解更多
  19. Gedunin
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    Gedunin

    Catalog No. A16034
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    HSP90 抑制剂
    Gedunin是天然存在的Hsp90抑制剂，是从印度印ne树（Azadirachta indica）分离得到的四降三萜。 了解更多
  20. TRC 051384
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    TRC 051384

    Catalog No. A16053
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    HSP70 inducer
    TRC 051384，属于取代的2-丙烯-1-酮类，是热休克蛋白70（HSP70）的有效诱导剂。HSP70的诱导是应激细胞的自然反应，可保护神经元细胞免受各种损伤，包括急性缺血。 了解更多
  21. EC 144
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    EC 144

    Catalog No. A16056
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    HSP90 抑制剂
    EC 144是热休克蛋白90的有效抑制剂，被发现可有效抑制肿瘤生长。 了解更多
  22. KRIBB11
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    KRIBB11

    Catalog No. A16347
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    HSF 抑制剂
    KRIBB11是HSF抑制剂，IC50为1.2 μM。 了解更多
  23. TRC051384
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    • 最新产品

    TRC051384

    Catalog No. A17159
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    Hsp70 inducer
    TRC051384是热休克蛋白Hsp70的诱导剂。 了解更多
  24. 17-AAG (KOS953)
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    17-AAG (KOS953)

    Catalog No. A10010
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    HSP90 抑制剂
    17-AAG (KOS953)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。 了解更多
  25. AUY922 (Luminespib, NVP-AUY922)
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    AUY922 (Luminespib, NVP-AUY922)

    Catalog No. A10659
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    HSP90 抑制剂
    AUY922 (Luminespib,NVP-AUY922)是一种高效的HSP90抑制剂，在Hsp90 FP结合测定中的IC50 = 21 nM，并在体外抑制多种人类癌细胞系的增殖，GI50平均为9 nM。Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂，无细胞试验中作用于HSP90α/β的IC50为13 nM /21 nM，对HSP90家族成员GRP94和TRAP-1具有稍弱的作用，与任何小分子HSP90配体均可紧密结合。 了解更多
  26. NVP-BEP800
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    NVP-BEP800

    Catalog No. A10660
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    HSP90 抑制剂
    NVP-BEP800是一种新型的，完全合成的，口服可生物利用的抑制剂，可与Hsp90的NH2末端ATP结合袋结合。 了解更多
  27. BIIB021
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    BIIB021

    Catalog No. A10143
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    HSP90 抑制剂
    BIIB021是一种口服全合成Hsp90抑制剂，可选择性和有效地抑制分子伴侣Hsp90。 了解更多
  28. Onalespib (AT13387)
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    Onalespib (AT13387)

    Catalog No. A11062
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    HSP90 抑制剂
    Onalespib (AT13387)是Hsp90的靶向抑制剂，可抑制其伴侣功能并促进涉及肿瘤细胞增殖和存活的致癌信号蛋白的降解。 了解更多
  29. Geldanamycin
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    Geldanamycin

    Catalog No. A11025
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    Hsp90 抑制剂
    Geldanamycin与Hsp90的ATP位点（Kd = 1.2μM）结合并抑制其分子伴侣活性。 了解更多
  30. PF-04929113 (SNX-5422)
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    PF-04929113 (SNX-5422)

    Catalog No. A11074
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    Hsp90 抑制剂
    PF-04929113 (SNX-5422)是一种有效的，选择性的HSP90抑制剂，Kd为41 nM，且诱导Her-2降解，IC50为37 nM。 了解更多
  31. Ganetespib (STA-9090)
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    Ganetespib (STA-9090)

    Catalog No. A11402
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    Hsp90 抑制剂
    Ganetespib (STA-9090)是Hsp90的有效合成小分子抑制剂，Hsp90是一种伴侣蛋白，对于某些其他蛋白的功能至关重要，这些蛋白可驱动许多不同类型的癌症的生长，增殖和存活。 了解更多
  32. 17-DMAG HCl (Alvespimycin)
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    17-DMAG HCl (Alvespimycin)

    Catalog No. A10011
    Hsp90 抑制剂
    17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物，与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。 了解更多
  33. SNX-2112
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    SNX-2112

    Catalog No. A11189
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    Hsp90 抑制剂
    SNX-2112是目前在临床试验中具有抗癌特性的热激蛋白90（Hsp90）抑制剂。SNX-2112通过Akt/mTOR/p70S6K抑制以时间和剂量依赖的方式诱导自噬。SNX-2112在人黑素瘤A-375细胞中诱导明显的凋亡和自噬，可能是有效的靶向治疗剂。 了解更多
  34. KW-2478
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    KW-2478

    Catalog No. A11195
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    HSP90 抑制剂
    KW-2478是一种靶向人热休克蛋白90（Hsp90）的药物，具有潜在的抗肿瘤活性。 了解更多
  35. MPC-3100
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    MPC-3100

    Catalog No. A11131
    Hsp90 抑制剂
    MPC-3100是口服可生物利用的合成第二代小分子热休克蛋白90（Hsp90）抑制剂，具有潜在的抗肿瘤活性。 了解更多
  36. PU-H71
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    PU-H71

    Catalog No. A11130
    Hsp90 抑制剂
    PU-H71是有效的Hsp90抑制剂（IC50 = 50 nM）。 了解更多
  37. Elesclomol (STA-4783)
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    Elesclomol (STA-4783)

    Catalog No. A10343
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    Elesclomol (STA-4783)通过激发癌细胞内活性氧的积累来诱导氧化应激。 了解更多
  38. IPI-504 (Retaspimycin HCl)
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    IPI-504 (Retaspimycin HCl)

    Catalog No. A11269
    Hsp90 抑制剂
    IPI-504 (Retaspimycin HCl)是新型的，有效的热休克蛋白90（Hsp90）抑制剂。 了解更多
  39. Radicicol
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    Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 抑制剂
    Radicicol是Hsp90，SRC和Cox-2的有效抑制剂。 了解更多
  40. XL-888
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    XL-888

    Catalog No. A11251
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    HSP90 抑制剂
    XL888是口服可生物利用的，具有ATP竞争性的小分子热休克蛋白90（Hsp90）抑制剂，IC50为24 nM。具有潜在的抗肿瘤活性。 了解更多
  41. CUDC-305 (DEBIO-0932 )
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    CUDC-305 (DEBIO-0932 )

    Catalog No. A12648
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    HSP90 抑制剂
    CUDC-305 (DEBIO-0932) 是一种新型的热休克蛋白90（HSP90）抑制剂，对HSP90 alpha/beta具有很强的亲和力，对HSP90α和HSP90β的IC50值分别为100和103nM。具有很高的口服生物利用度，并且对多种癌细胞系均具有强大的抗增殖活性（平均IC50为220 nmol/L）。包括许多对护理标准（SOC）药物有抵抗力的非小细胞肺癌（NSCLC）细胞系。 了解更多
  42. IPI-493
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    IPI-493

    Catalog No. A11272
    HSP90 抑制剂
    IPI-493是一种有效且口服可生物利用的HSP90抑制剂，Ki为21 nM。 了解更多
  43. HSP-990
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    HSP-990

    Catalog No. A12850
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    HSP90 抑制剂
    HSP990是人热休克蛋白90（Hsp90）的口服生物利用抑制剂，对HSP90α/β的IC50分别为0.6 nM和0.8 nM。具有潜在的抗肿瘤活性。 了解更多
  44. MKT 077
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    MKT 077

    Catalog No. A12388
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    HSP70 抑制剂
    MKT 077的p53结合位点，并使p53易位至细胞核。选择性细胞毒性；导致培养物中癌细胞生长停滞。也抑制端粒酶活性和交联f-肌动蛋白。 了解更多
  45. VER-50589
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    VER-50589

    Catalog No. A13817
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    Hsp90 抑制剂
    VER-50589是一种异恶唑化合物，可抑制Hsp90，IC50值为21 nM。 了解更多
  46. VER 155008
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    VER 155008

    Catalog No. A13351
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    HSP 70 抑制剂
    VER 155008是HSP70的小分子ATP衍生物抑制剂（IC50 = 500 nM）。 了解更多
  47. Geranylgeranylacetone
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    Geranylgeranylacetone

    Catalog No. A13667
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    Geranylgeranylacetone可以诱导HSP70，HSPB8和HSPB1的表达。 了解更多

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