JAK

Inhibitory Selectivity

Catalog No.	Inhibitor Name	JAK1	JAK2	JAK3	Tyk2	Other
A11041	Ruxolitinib	***	****
A10241	Tofacitinib Citrate	**	**	****		ROCK2,LCK
A10110	AZD1480		****
A11082	Fedratinib		****			FLT3,RET
A10095	AT9283		****	****	***	Aurora B,Aurora A,Abl1
A10047	AG-490		*			EGFR,ErbB2
A10263	Momelotinib	***	***	*
A11795	WP1066		*			STAT3
A11180	TG101209		***	*		RET,FLT3
A10546	Gandotinib	**	****	**	**	FLT3,FLT4,FGFR2
A11193	NVP-BSK805 2HCl	**	****	***	***
A11329	Baricitinib	***	***		**
A10104	AZ 960		****
A12808	CEP-33779		****
A12694	Pacritinib	*	**	*	**	FLT3 (D835Y),FLT3
A14049	WHI-P154			*		EGFR,Src,VEGFR
A12394	XL019	*	****	*	*	PDGFRβ,FLT3,c-Kit
A14955	S-Ruxolitinib	***	****	*	**
A13509	ZM 39923 HCl	*		**		TGM2,EGFR
A14012	Decernotinib	***	***	****	***
A14210	Cerdulatinib	***	***	***	****	ARK5,MST1,Fms
A14232	Filgotinib	***	**	*	*
A15911	FLLL32		*
A11241	BMS-911543	*	****	**	**
A14438	Peficitinib
A13162	GLPG0634 analogue
A12419	Go6976					FLT3,PKCα,PKCβ1
A10247	Curcumol
A11608	WHI-P97
A13082	PF-03394197 (oclacitinib)	***	***	**	**
A13457	Pyridone 6 (JAK Inhibitor I)	***	****	****
A14132	NSC 42834(JAK2 Inhibitor V, Z3)
A14390	INCB39110 (Itacitinib)
A14405	Solcitinib (GSK2586184)
A15134	JANEX-1			*
A15362	Cercosporamide			***		Mnk2, Mnk1
A15365	TCS 21311	*	*	***	*
A15366	ZM 449829	****		****		STAT-5, EGFR, CDK4
A15389	NSC 33994
A16227	ZM 39923	****		***		TGM2, EGFR

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Cucurbitacin I

Catalog No. A15363
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JAK2/STAT3 抑制剂

Cucurbitacin I（Cucumis sativus L.）可以抑制v-Src转化的NIH 3T3细胞中的磷酸酪氨酸Stat3（信号转导和转录激活因子3）水平。了解更多

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SD 1008

Catalog No. A15364
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JAK2/STAT3 抑制剂

SD 1008是JAK2/STAT3信号通路抑制剂，可额外抑制Src。注意到SD 1008可诱导表达组成性活性酪氨酸磷酸化STAT3的细胞系凋亡。了解更多

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FLLL32

Catalog No. A15911
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JAK2 抑制剂

FLLL32是一种有效的JAK2/STAT3双重抑制剂，IC50 <5 uM。了解更多

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