JAK

Inhibitory Selectivity

Catalog No.	Inhibitor Name	JAK1	JAK2	JAK3	Tyk2	Other
A11041	Ruxolitinib	***	****
A10241	Tofacitinib Citrate	**	**	****		ROCK2,LCK
A10110	AZD1480		****
A11082	Fedratinib		****			FLT3,RET
A10095	AT9283		****	****	***	Aurora B,Aurora A,Abl1
A10047	AG-490		*			EGFR,ErbB2
A10263	Momelotinib	***	***	*
A11795	WP1066		*			STAT3
A11180	TG101209		***	*		RET,FLT3
A10546	Gandotinib	**	****	**	**	FLT3,FLT4,FGFR2
A11193	NVP-BSK805 2HCl	**	****	***	***
A11329	Baricitinib	***	***		**
A10104	AZ 960		****
A12808	CEP-33779		****
A12694	Pacritinib	*	**	*	**	FLT3 (D835Y),FLT3
A14049	WHI-P154			*		EGFR,Src,VEGFR
A12394	XL019	*	****	*	*	PDGFRβ,FLT3,c-Kit
A14955	S-Ruxolitinib	***	****	*	**
A13509	ZM 39923 HCl	*		*		TGM2,EGFR
A14012	Decernotinib	***	***	****	***
A14210	Cerdulatinib	***	***	***	****	ARK5,MST1,Fms
A14232	Filgotinib	***	**	*	*
A15911	FLLL32		*
A11241	BMS-911543	*	****	**	**
A14438	Peficitinib
A13162	GLPG0634 analogue
A12419	Go6976					FLT3,PKCα,PKCβ1
A10247	Curcumol
A11608	WHI-P97
A13082	PF-03394197 (oclacitinib)	***	***	**	**
A13457	Pyridone 6 (JAK Inhibitor I)	***	****	****
A14132	NSC 42834(JAK2 Inhibitor V, Z3)
A14390	INCB39110 (Itacitinib)
A14405	Solcitinib (GSK2586184)
A15134	JANEX-1			*
A15362	Cercosporamide			***		Mnk2, Mnk1
A15365	TCS 21311	*	*	***	*
A15366	ZM 449829	****		****		STAT-5, EGFR, CDK4
A15389	NSC 33994
A16227	ZM 39923	*		*		TGM2, EGFR

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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AG-490

Catalog No. A10047
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EGFR 抑制剂

AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck，Lyn，Btk，Syk和Src无活性的JAK2。了解更多

Product Citations (1)

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- Matozaki M, .et al. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance, Exp Cell Res, 2019, Feb 15. pii: S0014-4827(18)31030-9 PMID: 30776355
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ZM 39923 HCl

Catalog No. A13509
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JAK3 抑制剂

ZM 39923 HCl是JAK3抑制剂（IC50 = 79 nM），其抑制表皮生长因子受体，JAK1和细胞周期蛋白依赖性激酶4（IC50s分别为2.4、40和10 M）的抑制作用较小。了解更多

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