HDAC

Inhibitory Selectivity

Catalog No.	Inhibitor Name	HDAC	HDAC1	HDAC2	HDAC3	HDAC4	HDAC5	HDAC6	HDAC7	HDAC8	HDAC9	HDAC10	HDAC11	HD1	HD2
A10979	Vorinostat	****
A10611	Entinostat		**		*
A10518	Panobinostat	****
A10947	Trichostatin A	****
A10586	Mocetinostat		**	**	*								*
A10122	Belinostat	***
A11920	Romidepsin		***	***
A10560	MC1568													*
A11042	Tubastatin A HCl		*					***
A10488	Givinostat													****	****
A10516	Dacinostat	***
A10246	CUDC-101	****	****	***	****	***	***	****	**	**	**	***
A10830	Pracinostat		***	**	***	***	***	*	**	**	**	***	**
A11152	PCI-34051		*					*		****		*
A10337	Droxinostat				*			*		*
A10700	Abexinostat		****	***	****			***		**		***
A13218	RGFP966				**
A11037	AR-42	***
A11940	Ricolinostat		**	***	***	*	*	****	*	**
A11964	Tacedinaline		*	*	*					**
A11153	CUDC-907		****	****	****	**	*	***	**		**	****	****
A11355	M344	**
A10954	Tubacin							****
A13139	RG2833		***		****
A12556	Resminostat		***		***			**
A15489	BRD73954			*				***		**
A11361	BG45		*	*	**
A14354	4SC-202		*	*	*
A16431	CAY10603		**					****
A14341	LMK-235					***	****
A14032	Nexturastat A							****
A14128	TMP269					**	**		***		***
A14197	HPOB		*	*	*			***		*		*
A12722	Scriptaid
A12616	Tasquinimod
A11042	Tubastatin A							***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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CUDC-907 (Fimepinostat)

Catalog No. A11153
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PI3K/HDAC 抑制剂

CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。了解更多

Product Citations (1)

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- Chie Ishikawa, .et al. The role of CUDC-907, a dual phosphoinositide-3 kinase and histone deacetylase inhibitor, in inhibiting proliferation of adult T-cell leukemia, Eur J Haematol, 2020, Eur J Haematol PMID: 32780889
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MGCD0103 (Mocetinostat)

Catalog No. A10586
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HDAC 抑制剂

MGCD0103 (Mocetinostat)是一种苯甲酰胺组蛋白脱乙酰基酶抑制剂，主要抑制组蛋白脱乙酰基酶1（HDAC1），但也抑制HDAC2，HDAC3和HDAC11。了解更多

Product Citations (2)

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- Mari Ishigami-Yuasa, .et al. Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer, Biol Pharm Bull, 2019, 42, 448-452
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
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Domatinostat (4SC-202)

Catalog No. A14354
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HDAC 抑制剂

4SC-202是生物利用的苯甲酰胺和人I类组蛋白脱乙酰基酶（HDACs）同工酶1、2和3的抑制剂，具有潜在的抗肿瘤活性。了解更多

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SIS-17

Catalog No. A18463
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HDAC 11 inhibitor

SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. 了解更多

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