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￥ 0.00 HDAC
| Catalog No. | Inhibitor Name | HDAC | HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 | HDAC10 | HDAC11 | HD1 | HD2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A10979 | Vorinostat | **** | |||||||||||||
| A10611 | Entinostat | ** | * | ||||||||||||
| A10518 | Panobinostat | **** | |||||||||||||
| A10947 | Trichostatin A | **** | |||||||||||||
| A10586 | Mocetinostat | ** | ** | * | * | ||||||||||
| A10122 | Belinostat | *** | |||||||||||||
| A11920 | Romidepsin | *** | *** | ||||||||||||
| A10560 | MC1568 | * | |||||||||||||
| A11042 | Tubastatin A HCl | * | *** | ||||||||||||
| A10488 | Givinostat | **** | **** | ||||||||||||
| A10516 | Dacinostat | *** | |||||||||||||
| A10246 | CUDC-101 | **** | **** | *** | **** | *** | *** | **** | ** | ** | ** | *** | |||
| A10830 | Pracinostat | *** | ** | *** | *** | *** | * | ** | ** | ** | *** | ** | |||
| A11152 | PCI-34051 | * | * | **** | * | ||||||||||
| A10337 | Droxinostat | * | * | * | |||||||||||
| A10700 | Abexinostat | **** | *** | **** | *** | ** | *** | ||||||||
| A13218 | RGFP966 | ** | |||||||||||||
| A11037 | AR-42 | *** | |||||||||||||
| A11940 | Ricolinostat | ** | *** | *** | * | * | **** | * | ** | ||||||
| A11964 | Tacedinaline | * | * | * | ** | ||||||||||
| A11153 | CUDC-907 | **** | **** | **** | ** | * | *** | ** | ** | **** | **** | ||||
| A11355 | M344 | ** | |||||||||||||
| A10954 | Tubacin | **** | |||||||||||||
| A13139 | RG2833 | *** | **** | ||||||||||||
| A12556 | Resminostat | *** | *** | ** | |||||||||||
| A15489 | BRD73954 | * | *** | ** | |||||||||||
| A11361 | BG45 | * | * | ** | |||||||||||
| A14354 | 4SC-202 | * | * | * | |||||||||||
| A16431 | CAY10603 | ** | **** | ||||||||||||
| A14341 | LMK-235 | *** | **** | ||||||||||||
| A14032 | Nexturastat A | **** | |||||||||||||
| A14128 | TMP269 | ** | ** | *** | *** | ||||||||||
| A14197 | HPOB | * | * | * | *** | * | * | ||||||||
| A12722 | Scriptaid | ||||||||||||||
| A12616 | Tasquinimod | ||||||||||||||
| A11042 | Tubastatin A | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Nexturastat A
Catalog No. A14032 HDAC6 抑制剂Nexturastat A是一种芳基脲衍生物，可作为组蛋白脱乙酰基酶6（HDAC6）的有效且高度选择性的抑制剂（IC50 = 5.02+/-0.60 nM）。 了解更多 -
Splitomicin
Catalog No. A14221 NAD(+)-dependent histone deacetylase Sir2p 抑制剂Splitomicin是一种选择性的NAD(+)-依赖性组蛋白脱乙酰基酶Sir2p抑制剂，IC50为60 uM，在基于细胞的测定中显示出更高的活性。 了解更多 -
Tasquinimod
Catalog No. A12616 -
Santacruzamate A
Catalog No. A14236 HDAC 抑制剂Santacruzamate A (CAY10683)是一种有效的选择性HDAC抑制剂，对HDAC2的IC50为119 pM，选择性是其他HDAC的3600倍以上。 了解更多 -
LMK-235
Catalog No. A14341 -
Domatinostat (4SC-202)
Catalog No. A14354 -
SR-4370
Catalog No. A16899 -
HDAC8-IN-1
Catalog No. A17091 -
Tinostamustine (EDO-S101)
Catalog No. A18342 HDAC inhibitorEDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. 了解更多 -
Valproic acid
Catalog No. A17323 HDAC inhibitorValproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. 了解更多 -
Tucidinostat (Chidamide)
Catalog No. A17861 HDAC inhibitorTucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. 了解更多 -
CHDI-390576
Catalog No. A18899 HDAC inhibitorCHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. 了解更多 -
Remetinostat
Catalog No. A12149 HDAC inhibitorRemetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma. 了解更多 -
HDACs/mTOR Inhibitor 1
Catalog No. A13462 HDACs/mTOR Inhibitor 1HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies. 了解更多 -
MS-275 (Entinostat)
Catalog No. A10611 HDAC 抑制剂MS-275 (Entinostat)是一种有效的HDAC抑制剂，对HDAC1和HDAC3的IC50分别为0.3和8uM。 了解更多 -
Trichostatin-A (TSA)
Catalog No. A10947 HDAC 抑制剂Trichostatin-A (TSA)是抑制HDAC 1、3、4、6和10，IC50值约为20 nM。 了解更多 -
Belinostat (PXD101)
Catalog No. A10122 HDAC 抑制剂Belinostat（PXD101）是一种HDAC抑制剂，可抑制HeLa细胞提取物中的HDAC活性，IC50为27 nM。 了解更多 -
LBH589 (Panobinostat)
Catalog No. A10518 HDAC 抑制剂LBH589是异羟肟酸，用作非选择性HDAC抑制剂，HDAC1的IC5o为0.23 nM。 了解更多 -
CUDC-101
Catalog No. A10246 -
MGCD0103 (Mocetinostat)
Catalog No. A10586 HDAC 抑制剂MGCD0103 (Mocetinostat)是一种苯甲酰胺组蛋白脱乙酰基酶抑制剂，主要抑制组蛋白脱乙酰基酶1（HDAC1），但也抑制HDAC2，HDAC3和HDAC11。 了解更多 -
Vorinostat (SAHA)
Catalog No. A10979 HDAC 抑制剂Vorinostat (SAHA)是HDAC的抑制剂，抑制脱乙酰和导致双方超乙酰化组蛋白和转录因子的积累。 了解更多 -
ITF2357 (Givinostat)
Catalog No. A10488 -
Droxinostat
Catalog No. A10337 HDAC 抑制剂Droxinostat是HDAC3，HDAC6和HDAC8的选择性抑制剂，显示出可比较的HDAC6和HDAC8抑制作用，IC50分别为2.47和1.46μmol/ L。 了解更多 -
AR-42 (HDAC-42)
Catalog No. A11037 HDAC 抑制剂AR-42 (HDAC-42)是一种新型的HDAC抑制剂，通过下调本构激活的Kit表现出对恶性肥大细胞系的生物学活性。 了解更多 -
PCI-24781 (Abexinostat)
Catalog No. A10700 -
Tubastatin A HCl
Catalog No. A11042 HDAC6 抑制剂Tubastatin A HCl是一种有效的选择性HDAC6抑制剂，在无细胞试验中IC50为15 nM。它对除HDAC8（57倍）以外的所有其他同工酶（1000倍）具有选择性。 了解更多 -
SB939 ( Pracinostat )
Catalog No. A10830 HDAC 抑制剂SB939 (Pracinostat)是HDAC的口服抑制剂，对I，II和IV类HDAC具有选择性，在体外HDAC1活性测定中显示IC50值为77 nM。 了解更多 -
JNJ-26481585 (Quisinostat)
Catalog No. A10492 HDAC 抑制剂JNJ-26481585 (Quisinostat)是一种pan-HDAC抑制剂，对HDAC1具有显著的效力(IC(50)，0.16 nmol/L)。 了解更多 -
Pyroxamide (NSC 696085)
Catalog No. A10764 HDAC 抑制剂Pyroxamide (NSC 696085)是亲和纯化的HDAC1的有效抑制剂，可导致乙酰化核心组蛋白在用该试剂培养的MEL细胞中积累。 了解更多 -
PCI-34051
Catalog No. A11152 -
CUDC-907 (Fimepinostat)
Catalog No. A11153 PI3K/HDAC 抑制剂CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。 了解更多 -
Parthenolide ((-)-Parthenolide)
Catalog No. A10698 Parthenolide ((-)-Parthenolide), Nuclear Factor-κB抑制剂，可特异性地耗尽HDAC1蛋白，而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。 了解更多 -
LAQ824 (NVP-LAQ824, Dacinostat)
Catalog No. A10516 HDAC 抑制剂LAQ824 (NVP-LAQ824)是一种有效的新型组蛋白去乙酰化酶抑制剂，具有显著的抗多发性骨髓瘤活性。 了解更多
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