EGFR / HER2

Inhibitory Selectivity

Catalog No.	Inhibitor Name	EGFR/ErbB1	HER2/ErbB2	ErbB3	ErbB4	Other
A10362	Erlotinib HCl	****
A10422	Gefitinib	**
A10514	Lapatinib Ditosylate	**	**		*	c-Src
A10141	Afatinib	****	**
A10638	Neratinib	*	*			KDR,Src
A10211	Canertinib	****	***
A11752	Lapatinib	**	**		*	c-Src
A10047	AG-490	*	*			JAK2
A10242	CP-724714		**
A11051	Dacomitinib	***	*		*
A10991	WZ4002	****		***
A10116	Sapitinib	***	***			HDAC,HDAC1,HDAC6
A10246	CUDC-101	***	**
A11022	AG-1478	***
A10702	PD153035 HCl	****				Src,MEK/ERK,Raf
A10706	Pelitinib	*	*			c-Abl,FLT1,c-Fms
A10043	AEE788	****	***		*	MEK,LCK,VEGFR2
A11209	AC480	**	*		*
A10678	OSI-420	****
A10990	WZ3146	****
A11155	AST-1306	****	***		****
A13028	Rociletinib	**
A11158	Varlitinib	***	****
A13825	Icotinib	***				MEK1,Aurora B,LCK
A11236	TAK-285	**	**		*	Src,VEGFR,JAK3
A14049	WHI-P154	***
A12725	PD168393	****
A13755	CNX-2006	**				PDGFR
A11949	Tyrphostin 9	*
A15940	AG-18	*
A15551	AZD3759	****
A14985	Afatinib Dimaleate	****	**
A13146	CL-387785	****
A13044	Poziotinib	***	***		**
A13681	Osimertinib	**				BLK,ACK1,BRK
A15516	AZ5104	****			***
A10992	WZ8040					topo II
A10426	Genistein
A12448	Butein					mTOR
A10210	Chrysophanic Acid
A10053	Tyrphostin AG 879		*			Trk
A10286	Daphnetin	*				PKC, PKA
A11027	Irbinitinib (ARRY-380, ONT-380)		****
A11028	AV-412	***	*
A11334	BIBX 1382	****	*
A12867	CGP-52411	*
A13588	Tyrphostin AG 183	*
A15509	WHI-P180	*				Cdk2
A10612	Mubritinib (TAK 165)		****
A16413	ARRY-380 (Irbinitinib)		****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Nazartinib mesylate

Catalog No. A21741
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covalent mutant-selective EGFR inhibitor

Nazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min?1 on EGFR(L858R/790M) mutant, respectively. 了解更多

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Nazartinib S-enantiomer

Catalog No. A21747
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EGFR inhibitor

Nazartinib S-enantiomer (EGF816 S-enantiomer) is the less active S-enantiomer of Nazartinib. Nazartinib (EGF816) is an EGFR inhibitor. 了解更多

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Pyrotinib dimaleate

Catalog No. A21756
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EGFR/HER2 dual inhibitor

Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 s of 13 and 38 nM, respectively. 了解更多

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Epertinib hydrochloride

Catalog No. A21950
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EGFR, HER2 and HER4 inhibitor

Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity. 了解更多

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Lifirafenib

Catalog No. A20988
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Raf/EGFR inhibitor

Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. 了解更多

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