EGFR/HER2

Inhibitory Selectivity

Catalog No.	Inhibitor Name	EGFR/ErbB1	HER2/ErbB2	ErbB3	ErbB4	Other
A10362	Erlotinib HCl	****
A10422	Gefitinib	**
A10514	Lapatinib Ditosylate	**	**		*	c-Src
A10141	Afatinib	****	**
A10638	Neratinib	*	*			KDR,Src
A10211	Canertinib	****	***
A11752	Lapatinib	**	**		*	c-Src
A10047	AG-490	*	*			JAK2
A10242	CP-724714		**
A11051	Dacomitinib	***	*		*
A10991	WZ4002	****		***
A10116	Sapitinib	***	***			HDAC,HDAC1,HDAC6
A10246	CUDC-101	***	**
A11022	AG-1478	***
A10702	PD153035 HCl	****				Src,MEK/ERK,Raf
A10706	Pelitinib	*	*			c-Abl,FLT1,c-Fms
A10043	AEE788	****	***		*	MEK,LCK,VEGFR2
A11209	AC480	**	*		*
A10678	OSI-420	****
A10990	WZ3146	****
A11155	AST-1306	****	***		****
A13028	Rociletinib	**
A11158	Varlitinib	***	****
A13825	Icotinib	***				MEK1,Aurora B,LCK
A11236	TAK-285	**	**		*	Src,VEGFR,JAK3
A14049	WHI-P154	***
A12725	PD168393	****
A13755	CNX-2006	**				PDGFR
A11949	Tyrphostin 9	*
A15940	AG-18	*
A15551	AZD3759	****
A14985	Afatinib Dimaleate	****	**
A13146	CL-387785	****
A13044	Poziotinib	***	***		**
A13681	Osimertinib	**				BLK,ACK1,BRK
A15516	AZ5104	****			***
A10992	WZ8040					topo II
A10426	Genistein
A12448	Butein					mTOR
A10210	Chrysophanic Acid
A10053	Tyrphostin AG 879		*			Trk
A10286	Daphnetin	*				PKC, PKA
A11027	Irbinitinib (ARRY-380, ONT-380)		****
A11028	AV-412	***	*
A11334	BIBX 1382	****	*
A12867	CGP-52411	*
A13588	Tyrphostin AG 183	*
A15509	WHI-P180	*				Cdk2
A10612	Mubritinib (TAK 165)		****
A16413	ARRY-380 (Irbinitinib)		****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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(-)-Epigallocatechin gallate

Catalog No. A10005
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Antioxidant, antiangiogenic, antitumor agent

(-)-Epigallocatechin gallate是一种从绿茶中分离出来的强效抗氧化剂多酚类黄酮。了解更多

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- Wafa Dridi, .et al. Influence of polysaccharide concentration on polyphenol-polysaccharide interactions, Carbohydr Polym, 2021, 274:118670 PMID: 34702486
- A S D'Costa, .et al. Inhibition of starch digestion by flavonoids: Role of flavonoid-amylase binding kinetics, Food Chem, 2020, Oct 1;341(Pt 2):128256 PMID: 33035827
- Fenteany G, .et al. Multilevel structure-activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism, Sci Rep, 2019, Sep 5;9(1):12801 PMID: 31488855
- LiliSun, .et al. Comparative Effect of Black, Green, Oolong and White Tea Intake on Body Weight Gain and Bile Acid Metabolism, Nutrition, 2019, pii:S0899-9007(18)31140-7
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Pelitinib (EKB-569)

Catalog No. A10706
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EGFR 抑制剂

Pelitinib (EKB-569)是一种有效的,不可逆EGFR抑制剂,IC50为38.5 nM 了解更多

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- Shi P, .et al. The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations, Transl Oncol, 2019, Mar 8;12(5):705-713 PMID: 30856555
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Canertinib (CI-1033)

Catalog No. A10211
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HER2/ErbB2 抑制剂

Canertinib (CI-1033)是一种不可逆的酪氨酸激酶抑制剂，对EGFR（IC50 0.8 nM），HER-2（IC50 19 nM）和ErbB-4（IC50 7 nM）具有活性。了解更多

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- Fukuda N, .et al. Rapid Evaluation of Tyrosine Kinase Activity of Membrane Integrated Human Epidermal Growth Factor Receptor Using the Yeast Gγ Recruitment System, ACS Synth Biol., 2015, 4(4):421-9 PMID: 25006755
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BIBW2992 (Afatinib)

Catalog No. A10141
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EGFR 抑制剂

BIBW2992 (Afatinib)是酪氨酸激酶抑制剂（TKI），它不可逆地抑制人表皮生长因子受体2（Her2）和表皮生长因子受体（EGFR）激酶。了解更多

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- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Van Sebille YZ, .et al. Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity, Exp Biol Med (Maywood), 2019, Jun 11:1535370219855334 PMID: 31184924
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
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AZD8931 (Sapitinib)

Catalog No. A10116
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pan-EGFR/pan-erbB 抑制剂

AZD8931 (Sapitinib)是ErbB1，ErbB2和ErbB3受体信号传导的等效抑制剂。了解更多

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- Takeshi Ito, .et al. Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification, Biochem Biophys Res Commun, 2019, in Press
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Gefitinib (Iressa)

Catalog No. A10422
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EGFR 抑制剂

Gefitinib (Iressa)是一种EGFR抑制剂，可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。了解更多

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- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Mansi Srivastava, .et al. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses, Int Immunopharmacol, 2019, 71: 188-197 PMID: 30909134
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Erlotinib HCl

Catalog No. A10362
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EGFR 抑制剂

Erlotinib hydrochloride是一种可逆的酪氨酸激酶抑制剂，作用于表皮生长因子受体（EGFR）。了解更多

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- Yuta Yamamoto, .et al. Quantitative determination of erlotinib in human serum using competitive enzyme-linked immunosorbent assay, J Pharm Anal, 2018, Apr; 8(2): 119-123 PMID: 29736298
- Aikawa S, .et al. Proliferation of mouse endometrial stromal cells in culture is highly sensitive to lysophosphatidic acid signaling, Biochem Biophys Res Commun, 2017, Feb 26;484(1):202-208 PMID: 28073697
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AG-1478 (Tyrphostin AG-1478)

Catalog No. A11022
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EGFR 抑制剂

AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂，IC50值为3 nM。了解更多

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- Khattab M, .et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 PMID: 29629773
- Muhammad Khattab, .et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 PMID: 29176733
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OSI-420

Catalog No. A10678
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EGFR 抑制剂

OSI-420 (Desmethyl Erlotinib,CP-473420)是一种口服活性EGFR酪氨酸激酶抑制剂，可通过抑制细胞间结构域来抑制受体酪氨酸激酶（TKs）。了解更多

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- Yuta Yamamoto, .et al. Quantitative determination of erlotinib in human serum using competitive enzyme-linked immunosorbent assay, J Pharm Anal, 2018, Apr; 8(2): 119-123 PMID: 29736298
- Janet L. Martin, .et al. Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade, Breast Cancer Res, 2017, 19: 90 PMID: 28778177
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CP-724714

Catalog No. A10242
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HER2/ErbB2 抑制剂

CP-724714是一种有效的，选择性HER2/ErbB2抑制剂，可抑制HER2激酶（IC50 3.8 ng/ml）。了解更多

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- Yu Muta, .et al. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine, Nat Commun, 2018, 9: 2174 PMID: 29872037
- Gina M. Sizemore, .et al. Stromal PTEN determines mammary epithelial response to radiotherapy, Nat Commun, 2018, 9: 2783 PMID: 30018330
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AV-412

Catalog No. A11028
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EGFR 抑制剂

AV-412是一种EGFR / HER2抑制剂，可与表皮生长因子受体（EGFR）和人表皮生长因子受体2（HER2）结合并抑制其生长，这可能会导致肿瘤生长和血管生成受到抑制。了解更多

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- Le Zhang, .et al. High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor, Oncotarget, 2016, Apr 12; 7(15): 19948-19959 PMID: 26942566
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AG-490

Catalog No. A10047
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EGFR 抑制剂

AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck，Lyn，Btk，Syk和Src无活性的JAK2。了解更多

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- Matozaki M, .et al. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance, Exp Cell Res, 2019, Feb 15. pii: S0014-4827(18)31030-9 PMID: 30776355
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PF299804 (Dacomitinib, PF299)

Catalog No. A11051
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EGFR 抑制剂

PF299804是一种有效的，可口服的酪氨酸激酶人表皮生长因子受体（HER）1（EGFR），HER2和HER4不可逆抑制剂。了解更多

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- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
- Majid Momeny, .et al. Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells, Sci Rep, 2017, 7: 4204 PMID: 28646172
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
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ARRY334543 (Varlitinib)

Catalog No. A11158
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EGFR 抑制剂

ARRY334543 (Varlitinib)是一种有效的EGFR和ErbB-2口服活性小分子抑制剂。了解更多

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- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
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Genistin (Genistoside)

Catalog No. A10426
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Genistin (Genistoside)是一种异黄酮，存在于许多饮食植物中，如大豆和葛根。显示出刺激体内雌激素依赖性乳腺癌细胞生长。了解更多

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- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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BMS-690514

Catalog No. A11263
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VEGFR/EGFR 抑制剂

BMS-690514是一种有效的选择性表皮生长因子受体（EGFR），HER2和HER4抑制剂，以及VEGF受体激酶。了解更多

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Lapatinib (free base)

Catalog No. A11752
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Lapatinib (free base)是一种双重酪氨酸激酶抑制剂，是一种有效的EGFR和ErbB2抑制剂，在无细胞试验中IC50分别为10.2和9.8 nM。可阻断HER2生长受体途径。了解更多

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- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
- Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
- Yuki Kawasaki, .et al. Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain, Sci Rep, 2016, 6: 31502 PMID: 27531070
- Tetsuya Saita, .et al. Preparation of Antibodies and Development of an Enzyme-Linked Immunosorbent Assay for the Tyrosine Kinase Inhibitors Lapatinib and Nilotinib., Biol Pharm Bull. , 2015, 38(10):1652-7 PMID: 26424026
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SU-5402

Catalog No. A11558
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VEGFR/FGFR/EGFR 抑制剂?

SU-5402是有效且选择性的血管内皮生长因子受体(VEGFR)和成纤维细胞生长因子受体(FGFR)抑制剂(在VEGFR2, FGFR1, PDGFRβ和EGFR处IC50值分别为0.02、0.03、0.51和> 100μM)。了解更多

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- Yan Zhang, etc. Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells. Cell Res. 2012 Apr; 22(4): 773–776.
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PKC 412 (Midostaurin)

Catalog No. A12650
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PKC 抑制剂

PKC 412 (Midostaurin)是一种广谱蛋白激酶抑制剂。抑制常规PKC亚型α/β/γ，PDFRβ，VEGFR2，Syk，Flk-1，Flt3，Cdk1/B，PKA，c-Kit，c-Fgr，c-Src，VEGFR1和EGFR。显示有效的抗肿瘤活性。了解更多

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Icotinib Hydrochloride

Catalog No. A13718
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EGFR 抑制剂

Icotinib hydrochloride是一种有效的特异性表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（TKI），IC（50）为5 nM，包括EGFR（L858R），EGFR（L861Q），EGFR（T790M）和EGFR的突变体（T790M，L858R）。了解更多

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AZD-9291 (Osimertinib)

Catalog No. A13681
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EGFR 抑制剂

AZD-9291 (Osimertinib)是第三代EGFR抑制剂，在临床前研究中显示出希望，并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。了解更多

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- Liu YN, .et al. Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer, Int J Cancer, 2019, Jun 4 PMID: 31162839
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Tyrphostin AG 183

Catalog No. A13588
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EGFR 抑制剂

Tyrphostin AG 183抑制EGFR（表皮生长因子受体）酪氨酸激酶（IC50 = 800 nM）。了解更多

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CNX-2006

Catalog No. A13755
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EGFR 抑制剂

CNX-2006是一种有效的突变体选择性EGFR抑制剂，在具有激活性EGFR突变的细胞以及具有T790M突变的细胞中具有出色的体外活性。CNX-2006是CO-1686的原型，目前正在I期临床试验中，用于治疗EGFR突变型肺癌。了解更多

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Icotinib

Catalog No. A13825
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EGFR 抑制剂

Icotinib是一种有效的特异性EGFR抑制剂，IC50为5 nM，包括EGFR，EGFR（L858R），EGFR（L861Q），EGFR（T790M）和EGFR（T790M，L858R）。了解更多

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Afatinib dimaleate

Catalog No. A14985
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EGFR 抑制剂

Afatinib dimaleate是一种不可逆的EGFR/HER2抑制剂，对于HER2的体外药效IC50为14 nM。了解更多

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Erlotinib mesylate

Catalog No. A15081
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EGFR 抑制剂

Erlotinib mesylate是人EGFR酪氨酸激酶的直接作用抑制剂，IC50为2 nM。了解更多

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Gefitinib hydrochloride

Catalog No. A15093
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EGFR 抑制剂

Gefitinib hydrochloride是一种EGFR抑制剂，可通过靶细胞中的表皮生长因子受体（EGFR）中断信号传导。因此，它仅在EGFR突变和过度活跃的癌症中有效。了解更多

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Vandetanib trifluoroacetate

Catalog No. A15272
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VEGFR/EGFR 抑制剂

Vandetanib trifluoroacetate是一种有效的VEGFR2抑制剂，IC50为40 nM。了解更多

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WHI-P180

Catalog No. A15509
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EGFR/Cdk2 抑制剂

WHI-P180是有效的EGFR和Cdk2抑制剂，IC50分别为4.0和1.0 uM。了解更多

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AZ5104

Catalog No. A15516
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EGFR 抑制剂

AZD-9291的去甲基代谢产物AZ5104是一种有效的EGFR抑制剂，对于EGFR（L858R/T790M），EGFR（L858R），EGFR（L861Q）和EGFR，IC50 <1 nM，6 nM，1 nM和25 nM EGFR（野生型）。了解更多

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AZD3759

Catalog No. A15551
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EGFR 抑制剂

AZD3759是表皮生长因子受体（EGFR）的口服抑制剂。它结合并抑制EGFR以及某些突变形式的EGFR的活性。了解更多

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ASP8273 (Naquotinib)

Catalog No. A14408
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irreversible EGFR 抑制剂

ASP8273 (Naquotinib)是不可逆的，第三代，选择性突变的表皮生长因子受体（EGFR）抑制剂，具有潜在的抗肿瘤活性。了解更多

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EGF816 (Nazartinib)

Catalog No. A14416
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EGFR T790M 抑制剂

EGF816 (Nazartinib)是新型的突变选择性EGFR共价抑制剂。克服了NSCLC中T790M介导的耐药性。了解更多

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AG-18 (Tyrphostin 23)

Catalog No. A15940
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EGFR 抑制剂

AG-18 (Tyrphostin 23)是人表皮癌细胞系A431中的表皮生长因子（EGF）受体激酶抑制剂，IC50值为35M。了解更多

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DM1-SMCC

Catalog No. A15955
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potent EGFR 抑制剂

DM1-SMCC是具有反应性接头SMCC的DM1，后者可与抗体反应以形成抗体-药物偶联物。了解更多

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Neratinib (HKI-272)

Catalog No. A10638
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HER2 抑制剂

Neratinib (HKI-272)是一种酪氨酸激酶抑制剂。了解更多

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- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
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WZ4002

Catalog No. A10991
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EGFR 抑制剂

WZ4002是一种新型的，突变选择性EGFR抑制剂，作用于EGFR(L858R)/(T790M)，在BaF3细胞系中IC50为2 nM/8 nM；对ERBB2磷酸化(T798I)没有抑制作用。了解更多

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Lapatinib Ditosylate

Catalog No. A10514
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HER2 抑制剂

Lapatinib是一种双重酪氨酸激酶抑制剂，可阻断HER2生长受体途径。了解更多

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WZ8040

Catalog No. A10992
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EGFR 抑制剂

WZ8040是一种新型的EGFR抑制剂，可抑制含有EGFR-T790M的细胞系的生长并抑制EGFR磷酸化。了解更多

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WZ3146

Catalog No. A10990
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EGFR 抑制剂

WZ3146是EGFR受体激酶突变体的抑制剂，该突变体在活性位点网守残基（T790M）中带有突变，并且对野生型EGFR激酶的效力要低得多。了解更多

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PD153035 (HCl salt)

Catalog No. A10702
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EGFR 抑制剂

PD153035 (HCl salt)是EGFR酪氨酸激酶活性的极其有效和特异的抑制剂。了解更多

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BMS 599626 (AC480)

Catalog No. A11209
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EGFR 抑制剂

BMS 599626 (AC480)是一种选择性的，高效效的HER1，HER2和HER4酪氨酸激酶抑制剂（IC50分别为22、32和190 nM），具有潜在的抗肿瘤活性。了解更多

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Arry-380 analog

Catalog No. A11027
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HER2 抑制剂

Arry-380 analog是一种ErbB-2抑制剂，可选择性结合并抑制ErbB-2的磷酸化，从而导致表达ErbB-2的肿瘤细胞的生长抑制和死亡。了解更多

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AEE788

Catalog No. A10043
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EGFR 抑制剂

AEE788是一种口服生物可用的多受体酪氨酸激酶抑制剂，可抑制EGFR，HER2和VEGF2酪氨酸激酶的磷酸化。了解更多

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Chrysophanic acid (Chrysophanol)

Catalog No. A10210
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EGFR 抑制剂

Chrysophanic acid (Chrysophanol)是通过抑制EGFR/mTOR通路来阻止结肠癌细胞的增殖。了解更多

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XL647 (Tesevatinib)

Catalog No. A11057
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EGFR, HER2 and VEGFR 抑制剂

XL647 (Tesevatinib)是一种口服生物可利用的小分子RTK抑制剂，可结合并抑制在肿瘤细胞增殖和肿瘤血管形成中起主要作用的几种酪氨酸受体激酶，包括EGFR，HER2，ERBB2，VEGFR和EphB4。了解更多

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AST-1306

Catalog No. A11155
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EGFR 抑制剂

AST-1306是一种新型的苯胺-喹唑啉化合物，在无细胞和基于细胞的系统中均抑制野生型表皮生长因子受体（EGFR）和ErbB2以及EGFR抗性突变体的酶活性。了解更多

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Daphnetin

Catalog No. A10286
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EGFR, PKA,PKC 抑制剂

Daphnetin是一种香豆素类似物，可作为几种蛋白激酶的抑制剂。它在体外抑制EGFR激酶（IC50 = 7.67 ?M），PKA（IC50 = 9.33 ?M）和PKC（IC50 = 25 ?M）。蜂胶对EGFR激酶的抑制作用与ATP竞争，对肽底物没有竞争性。还可以用作有效的抗氧化剂和抗疟疾剂。了解更多

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Mubritinib (TAK 165)

Catalog No. A10612
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HER2/ErbB2 抑制剂

Mubritinib (TAK 165)是一种有效的EGFR和p34cdc2抑制剂，IC50分别为6 nM和0.2 ?M。Mubritinib（TAK 165）也抑制p33cdk2和p33cdk5。了解更多

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TAK-285

Catalog No. A11236
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HER2/EGFR 抑制剂

TAK-285是一种研究性的HER2/EGFR抑制剂，可在具有完整血脑屏障 (BBB) 的大鼠中穿透CNS。TAK-285对HER2和EGFR激酶具有抑制活性，HER2和EGFR的IC50值分别为17 nmol/L (95％CI 12-24)和23 nmol/L (95％CI 18-30)。了解更多

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