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￥ 0.00 EGFR/HER2
| Catalog No. | Inhibitor Name | EGFR/ErbB1 | HER2/ErbB2 | ErbB3 | ErbB4 | Other |
|---|---|---|---|---|---|---|
| A10362 | Erlotinib HCl | **** | ||||
| A10422 | Gefitinib | ** | ||||
| A10514 | Lapatinib Ditosylate | ** | ** | * | c-Src | |
| A10141 | Afatinib | **** | ** | |||
| A10638 | Neratinib | * | * | KDR,Src | ||
| A10211 | Canertinib | **** | *** | |||
| A11752 | Lapatinib | ** | ** | * | c-Src | |
| A10047 | AG-490 | * | * | JAK2 | ||
| A10242 | CP-724714 | ** | ||||
| A11051 | Dacomitinib | *** | * | * | ||
| A10991 | WZ4002 | **** | *** | |||
| A10116 | Sapitinib | *** | *** | HDAC,HDAC1,HDAC6 | ||
| A10246 | CUDC-101 | *** | ** | |||
| A11022 | AG-1478 | *** | ||||
| A10702 | PD153035 HCl | **** | Src,MEK/ERK,Raf | |||
| A10706 | Pelitinib | * | * | c-Abl,FLT1,c-Fms | ||
| A10043 | AEE788 | **** | *** | * | MEK,LCK,VEGFR2 | |
| A11209 | AC480 | ** | * | * | ||
| A10678 | OSI-420 | **** | ||||
| A10990 | WZ3146 | **** | ||||
| A11155 | AST-1306 | **** | *** | **** | ||
| A13028 | Rociletinib | ** | ||||
| A11158 | Varlitinib | *** | **** | |||
| A13825 | Icotinib | *** | MEK1,Aurora B,LCK | |||
| A11236 | TAK-285 | ** | ** | * | Src,VEGFR,JAK3 | |
| A14049 | WHI-P154 | *** | ||||
| A12725 | PD168393 | **** | ||||
| A13755 | CNX-2006 | ** | PDGFR | |||
| A11949 | Tyrphostin 9 | * | ||||
| A15940 | AG-18 | * | ||||
| A15551 | AZD3759 | **** | ||||
| A14985 | Afatinib Dimaleate | **** | ** | |||
| A13146 | CL-387785 | **** | ||||
| A13044 | Poziotinib | *** | *** | ** | ||
| A13681 | Osimertinib | ** | BLK,ACK1,BRK | |||
| A15516 | AZ5104 | **** | *** | |||
| A10992 | WZ8040 | topo II | ||||
| A10426 | Genistein | |||||
| A12448 | Butein | mTOR | ||||
| A10210 | Chrysophanic Acid | |||||
| A10053 | Tyrphostin AG 879 | * | Trk | |||
| A10286 | Daphnetin | * | PKC, PKA | |||
| A11027 | Irbinitinib (ARRY-380, ONT-380) | **** | ||||
| A11028 | AV-412 | *** | * | |||
| A11334 | BIBX 1382 | **** | * | |||
| A12867 | CGP-52411 | * | ||||
| A13588 | Tyrphostin AG 183 | * | ||||
| A15509 | WHI-P180 | * | Cdk2 | |||
| A10612 | Mubritinib (TAK 165) | **** | ||||
| A16413 | ARRY-380 (Irbinitinib) | **** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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AZD-9291 (Osimertinib)
Catalog No. A13681 EGFR 抑制剂AZD-9291 (Osimertinib)是第三代EGFR抑制剂，在临床前研究中显示出希望，并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。 了解更多 -
CO-1686 (Rociletinib, AVL-301)
Catalog No. A13028 EGFR 抑制剂CO-1686是一种新型的口服靶向共价（不可逆）抑制剂，可抑制表皮生长因子受体（EGFR）的致癌突变形式，目前正在研究用于治疗非小细胞肺癌（NSCLC）。 了解更多
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