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- 作用机制
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- Inhibitor (抑制剂) (96)
- Agonist (激动剂) (1)
- Degrader (降解剂) (1)
- 靶点
| Catalog No. | Inhibitor Name | CDK1 | CDK2 | CDK3 | CDK4 | CDK5 | CDK6 | CDK7 | CDK8 | CDK9 | CLK | CDK | Cdc | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A10701 | Palbociclib HCl | **** | *** | |||||||||||
| A10806 | Roscovitine | * | ** | * | ERK2,GST-ERK1,ERK1 | |||||||||
| A10850 | SNS-032 | * | *** | * | * | ** | **** | GSK-3α,GSK-3β | ||||||
| A11129 | Dinaciclib | **** | **** | **** | **** | |||||||||
| A10390 | Flavopiridol | *** | *** | *** | ** | * | ||||||||
| A10093 | AT7519 | ** | ** | ** | *** | ** | * | **** | GSK-3β | |||||
| A11045 | Flavopiridol HCl | *** | *** | * | *** | *** | * | |||||||
| A10494 | JNJ-7706621 | **** | **** | * | ** | Aurora A,Aurora B,VEGFR2 | ||||||||
| A11105 | AZD5438 | *** | **** | ** | *** | |||||||||
| A11167 | MK-8776 | ** | Chk1,Chk2 | |||||||||||
| A10716 | PHA-793887 | ** | **** | ** | **** | **** | ** | GSK-3β | ||||||
| A10163 | BS-181 HCl | *** | ||||||||||||
| A13811 | Palbociclib Isethionate | **** | *** | |||||||||||
| A11034 | A-674563 | ** | Akt1,PKA,GSK-3β | |||||||||||
| A16386 | abemaciclib | **** | **** | |||||||||||
| A11154 | BMS-265246 | **** | **** | ** | ||||||||||
| A11164 | PHA-767491 | ** | ** | * | *** | **** | **** | GSK-3β,MK2,PLK1 | ||||||
| A11047 | Milciclib | * | *** | ** | * | ** | TrkA | |||||||
| A11190 | R547 | **** | **** | **** | GSK-3β | |||||||||
| A14136 | NU6027 | * | * | ATR,DNA-PK | ||||||||||
| A13547 | P276-00 | ** | ** | ** | * | * | *** | GSK-3β,PKCα,c-Src | ||||||
| A11220 | Kenpaullone | * | * | * | GSK-3β,ERK2,c-Src | |||||||||
| A15889 | K03861 | **** | ||||||||||||
| A14192 | THZ1 | **** | ||||||||||||
| A11313 | AT7519 HCl | ** | ** | * | ** | *** | ** | * | **** | GSK-3β | ||||
| A15517 | Purvalanol A | *** | * | **** | ||||||||||
| A14437 | Ro-3306 | *** | PKCδ,SGK,ERK | |||||||||||
| A14318 | SU9516 | *** | *** | ** | PDGFR | |||||||||
| A13677 | XL413 | **** | **** | Pim1,CK2 | ||||||||||
| A14273 | LDC000067 | * | * | * | *** | |||||||||
| A14297 | ML167 | ** | ||||||||||||
| A13721 | TG003 | *** | ||||||||||||
| A13549 | Ribociclib | |||||||||||||
| A12216 | Wogonin | |||||||||||||
| A10471 | Indirubin | * | GSK-3β | |||||||||||
| A11347 | CGP60474 | *** | *** | PKCα | ||||||||||
| A12352 | Purvalanol B | **** | **** | |||||||||||
| A12438 | NU 6102 | *** | **** | * | ||||||||||
| A12989 | LY2835219 (abemaciclib) | **** | *** | |||||||||||
| A14025 | AMG-925 | * | **** | FLT3 | ||||||||||
| A15054 | CVT 313 | * | * | * | ||||||||||
| A15196 | NVP-LCQ195 | **** | *** | **** | CHK2 | |||||||||
| A15767 | NU2058 | * | * | DNA topoisomerase II ATPase | ||||||||||
| A15823 | LY2857785 | * | *** | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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LEE011 (Ribociclib)
Catalog No. A13549 CDK4/6 抑制剂LEE011 (Ribociclib)是一种可口服的细胞周期蛋白依赖性激酶（CDK）抑制剂，靶向细胞周期蛋白D1/CDK4和细胞周期蛋白D3/CDK6细胞周期途径，具有潜在的抗肿瘤活性。 了解更多 -
PD 0332991 Isethionate
Catalog No. A13811 CDK4/6 抑制剂PD 0332991 Isethionate是CDK4/6的高选择性抑制剂，IC50分别为11 nM/16 nM。 了解更多 -
AMG-925
Catalog No. A14025 -
Purvalanol A
Catalog No. A15517 CDK 抑制剂Purvalanol A是一种有效的细胞渗透性细胞周期蛋白依赖性蛋白激酶（cdk）抑制剂。对于cdc2/cyclin B，cdk2/cyclin A，cdk2/cyclin E，cdk4/cyclin D1和cdk5-p35，IC50值分别为4、70、35、850和75 nM。 了解更多 -
NVP-LCQ195
Catalog No. A15196 -
AG-024322
Catalog No. A15485 -
NU2058
Catalog No. A15767 -
Senexin A
Catalog No. A21166 -
Voruciclib hydrochloride
Catalog No. A21385 CDK inhibitorVoruciclib hydrochloride is a clinical stage orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. 了解更多 -
PHA-767491 hydrochloride
Catalog No. A21395 dual Cdc7/Cdk9 inhibitorPHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. 了解更多 -
(±)-BAY-1251152
Catalog No. A21564 PTEF/CDK9 inhibitor(±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. 了解更多 -
(-)-BAY-1251152
Catalog No. A21570 PTEF/CDK9 inhibitor(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. 了解更多 -
Lerociclib dihydrochloride
Catalog No. A21577 CDK4/CDK6 inhibitorLerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. 了解更多 -
BS-181 hydrochloride
Catalog No. A21988 CDK7 inhibitorBS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. 了解更多 -
SEL120-34A HCl
Catalog No. A21485 CDK8 inhibitorSEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. 了解更多 -
PD 0332991 HCl (Palbociclib)
Catalog No. A10701 CDK 4/6 抑制剂PD 0332991 HCl (Palbociclib)是一种高度选择性的CDK4/6抑制剂，它对CDK1/2/5，EGFR，FGFR，PDGFR，InsR等没有抑制活性，具有潜在的抗肿瘤活性。 了解更多 -
Flavopiridol (Alvocidib)
Catalog No. A10390 CDK 抑制剂Flavopiridol（Alvocidib）是一种细胞周期蛋白依赖性激酶抑制剂，与ATP竞争性抑制CDK，包括CDK1， CDK2， CDK4和CDK6，CDK9。作用于CDK1， 2， 4， 6，9比作用于CDK7更具有选择性，用于治疗慢性淋巴细胞性白血病。 了解更多 -
Roscovitine (Seliciclib)
Catalog No. A10806 CDK 抑制剂Roscovitine (Seliciclib)是一种CDK抑制剂，可优先抑制多种酶靶标，包括CDK2，CDK7和CDK9。 了解更多 -
PHA-793887
Catalog No. A10716 CDK 抑制剂PHA-793887是一种新型有效的CDK2，CDK5和CDK7抑制剂，IC50分别为8 nM，5 nM 和10 nM，作用于CDK2，5，和7比作用于CDK1，4，和9选择性高6倍以上。可在低浓度下靶向多种细胞周期蛋白依赖性激酶，并具有针对多种癌细胞的高活性。 了解更多 -
PHA-767491
Catalog No. A11164 Cdc7/cdk9 抑制剂PHA-767491是一种有效的，具有ATP竞争性的双重cdc7/cdk9抑制剂 (IC50值分别为10和34 nM)，可防止DNA复制的启动。 了解更多 -
SCH 900776 (MK-8776)
Catalog No. A11167 Chk1 抑制剂SCH 900776 (MK-8776)是靶向细胞周期检查点激酶1（Chk1）的药物，无细胞试验中IC50为3 nM，比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。 了解更多 -
Dinaciclib (SCH 727965)
Catalog No. A11129 CDK 抑制剂Dinaciclib (SCH 727965)是一种有效且选择性的细胞周期蛋白依赖性激酶（CDK）抑制剂，选择性抑制CDK1，CDK2，CDK5和CDK9，IC50值分别为3、1、1和4 nM。 了解更多 -
Kenpaullone
Catalog No. A11220 CDK 抑制剂Kenpaullone是CDK1/细胞周期蛋白B（IC 50 = 400 nM），CDK2/细胞周期蛋白A（IC 50 = 680nM），CDK5（IC 50 = 850nM）的有效抑制剂，对其他激酶的作用要小得多。 了解更多 -
BMS-863233 (XL-413)
Catalog No. A13677 CDK 抑制剂BMS-863233，也称为XL-413，是一种具有潜在抗肿瘤活性的细胞分裂周期7同系物（CDC7）激酶抑制剂。 了解更多 -
LY2835219 (abemaciclib)
Catalog No. A12989 CDK4/6 抑制剂LY2835219 (abemaciclib)是一种细胞周期蛋白依赖性激酶（CDK）抑制剂，靶向CDK4（cyclin D1）和CDK6（cyclin D3）细胞周期途径，具有潜在的抗肿瘤活性。 了解更多 -
BAY 1000394 (Roniciclib)
Catalog No. A12742 CDK 抑制剂BAY 1000394 (Roniciclib)是一种口服生物利用细胞周期蛋白依赖性激酶（CDK）抑制剂，具有潜在的抗肿瘤活性。 了解更多 -
Abemaciclib Metabolites M2
Catalog No. A18416 CDK4/CDK6 inhibitorAbemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity. 了解更多 -
FMF-04-159-2
Catalog No. A18911 CDK14 inhibitorFMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. 了解更多 -
THAL-SNS-032
Catalog No. A19088 CDK9 degrader PROTACTHAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多 -
CDK4/6-IN-2
Catalog No. A18657 CDK4/CDK6 inhibitorCDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor with IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively. 了解更多 -
Lerociclib (G1T38)
Catalog No. A18320 CDK inhibitorLerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. 了解更多