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| Catalog No. | Inhibitor Name | CDK1 | CDK2 | CDK3 | CDK4 | CDK5 | CDK6 | CDK7 | CDK8 | CDK9 | CLK | CDK | Cdc | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A10701 | Palbociclib HCl | **** | *** | |||||||||||
| A10806 | Roscovitine | * | ** | * | ERK2,GST-ERK1,ERK1 | |||||||||
| A10850 | SNS-032 | * | *** | * | * | ** | **** | GSK-3α,GSK-3β | ||||||
| A11129 | Dinaciclib | **** | **** | **** | **** | |||||||||
| A10390 | Flavopiridol | *** | *** | *** | ** | * | ||||||||
| A10093 | AT7519 | ** | ** | ** | *** | ** | * | **** | GSK-3β | |||||
| A11045 | Flavopiridol HCl | *** | *** | * | *** | *** | * | |||||||
| A10494 | JNJ-7706621 | **** | **** | * | ** | Aurora A,Aurora B,VEGFR2 | ||||||||
| A11105 | AZD5438 | *** | **** | ** | *** | |||||||||
| A11167 | MK-8776 | ** | Chk1,Chk2 | |||||||||||
| A10716 | PHA-793887 | ** | **** | ** | **** | **** | ** | GSK-3β | ||||||
| A10163 | BS-181 HCl | *** | ||||||||||||
| A13811 | Palbociclib Isethionate | **** | *** | |||||||||||
| A11034 | A-674563 | ** | Akt1,PKA,GSK-3β | |||||||||||
| A16386 | abemaciclib | **** | **** | |||||||||||
| A11154 | BMS-265246 | **** | **** | ** | ||||||||||
| A11164 | PHA-767491 | ** | ** | * | *** | **** | **** | GSK-3β,MK2,PLK1 | ||||||
| A11047 | Milciclib | * | *** | ** | * | ** | TrkA | |||||||
| A11190 | R547 | **** | **** | **** | GSK-3β | |||||||||
| A14136 | NU6027 | * | * | ATR,DNA-PK | ||||||||||
| A13547 | P276-00 | ** | ** | ** | * | * | *** | GSK-3β,PKCα,c-Src | ||||||
| A11220 | Kenpaullone | * | * | * | GSK-3β,ERK2,c-Src | |||||||||
| A15889 | K03861 | **** | ||||||||||||
| A14192 | THZ1 | **** | ||||||||||||
| A11313 | AT7519 HCl | ** | ** | * | ** | *** | ** | * | **** | GSK-3β | ||||
| A15517 | Purvalanol A | *** | * | **** | ||||||||||
| A14437 | Ro-3306 | *** | PKCδ,SGK,ERK | |||||||||||
| A14318 | SU9516 | *** | *** | ** | PDGFR | |||||||||
| A13677 | XL413 | **** | **** | Pim1,CK2 | ||||||||||
| A14273 | LDC000067 | * | * | * | *** | |||||||||
| A14297 | ML167 | ** | ||||||||||||
| A13721 | TG003 | *** | ||||||||||||
| A13549 | Ribociclib | |||||||||||||
| A12216 | Wogonin | |||||||||||||
| A10471 | Indirubin | * | GSK-3β | |||||||||||
| A11347 | CGP60474 | *** | *** | PKCα | ||||||||||
| A12352 | Purvalanol B | **** | **** | |||||||||||
| A12438 | NU 6102 | *** | **** | * | ||||||||||
| A12989 | LY2835219 (abemaciclib) | **** | *** | |||||||||||
| A14025 | AMG-925 | * | **** | FLT3 | ||||||||||
| A15054 | CVT 313 | * | * | * | ||||||||||
| A15196 | NVP-LCQ195 | **** | *** | **** | CHK2 | |||||||||
| A15767 | NU2058 | * | * | DNA topoisomerase II ATPase | ||||||||||
| A15823 | LY2857785 | * | *** | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
3 个项目
每页
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JNJ-7706621
Catalog No. A10494 CDK/Aurora A/B 抑制剂JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂，IC50为9 nM/4 nM，并且在无细胞分析中对CDK1/2的选择性是CDK3/4/6的6倍以上。它还能有效抑制极光A/B，对Plk1和Wee1没有活性。 了解更多 -
TG-02 (SB1317)
Catalog No. A11962 -
SB1317 (TG02)
Catalog No. A13454 CDK/JAK2/FLT3 抑制剂SB1317是细胞周期蛋白依赖性激酶（CDKs）、类FMS酪氨酸激酶-3（FLT3）和Janus激酶2（JAK2）的有效抑制剂，CDK2、JAK2和FLT3的IC50值分别为13nM、56nM和73nM。 了解更多
3 个项目
每页