VEGFR

Inhibitory Selectivity

Catalog No.	Inhibitor Name	VEGFR1	VEGFR2	VEGFR3	Other
A10001	Sorafenib Tosylate		**		Raf-1,B-Raf,B-Raf (V599E)
A10880	Sunitinib Malate		*		Kit,FLT3,PDGFRβ
A10996	Cabozantinib	***	****	***	c-Met,Kit,Axl
A10080	Ponatinib		****		Abl,PDGFRα,FGFR1
A10103	Axitinib	****	****	****	PDGFRβ,Kit,PDGFRα
A10998	Foretinib	***	****	****	Met,Tie-2,RON
A10963	Vandetanib		**	*
A10137	Nintedanib	**	***	***	LCK,FLT3,FGFR2
A10250	Regorafenib	***	****	*	RET,Raf-1,Kit
A11518	Pazopanib HCl	***	**	*	FGFR,PDGFR,c-Kit
A10185	Cediranib	***	****	****	c-Kit,PDGFRβ,FGFR1
A10703	PD173074		*		FGFR1,c-Src
A11411	Dovitinib	***	***	***	FLT3,c-Kit,FGFR1
A10025	Linifanib	****	****	*	CSF-1R,FLT3,Kit
A10967	Vatalanib 2HCl	*	**	*	PDGFRβ,c-Kit,c-Fms
A10773	RAF265		**		B-Raf
A10101	Tivozanib	**	***	**	EphB2,PDGFRα,PDGFRβ
A10608	Motesanib Diphosphate	****	****	***	Kit,RET,PDGFR
A10340	Lenvatinib	**	****	***	PDGFRβ,FGFR1,PDGFRα
A10953	Orantinib		*		PDGFRβ,FGFR1
A10254	Brivanib	*	**		FGFR1
A10587	MGCD-265	****	****	****	Met,RON,Tie-2
A10043	AEE788	*	*	*	EGFR,HER2/ErbB2,c-Abl
A10352	ENMD-2076		*	**	FLT3,RET,Aurora A
A10679	OSI-930	***	***		CSF-1R,LCK,C-Raf
A10248	CYC116		**		Aurora A,Aurora B,FLT3
A10502	Ki8751		****		c-Kit,PDGFRα,FGFR2
A10903	Telatinib		***	****	c-Kit,PDGFRα
A11518	Pazopanib	***	**	*	FGFR,PDGFR,c-Kit
A10504	KRN 633	*	*	*	PDGFRα,c-Kit,BTK
A13377	SAR131675			**
A10198	Dovitinib Dilactic Acid	***	***	***	FLT3,c-Kit,FGFR1
A11407	Apatinib		****		RET,c-Kit,c-Src
A10154	BMS-794833		**		Met
A10162	Brivanib Alaninate	*	**		FGFR1
A11396	Golvatinib		**		c-Met
A11954	ZM 323881 HCl		****
A11955	ZM 306416	*			Src,Abl
A16342	BFH772		****
A11558	SU5402		**		FGFR1,PDGFRβ
A12437	Semaxanib		*
A11244	LY2874455		***		FGFR2,FGFR1,FGFR4
A13234	SKLB1002		**
A14156	AZD2932		***		PDGFRβ,Flt3,c-Kit
A10893	Taxifolin (Dihydroquercetin)
A11772	CP-547632		***		FGFR
A12693	BAW2881 (NVP-BAW2881)	*	***	*	C-Raf-1,B-RAFV599E,c-Abl
A13465	SKLB610		*		PDGFR, FGFR2
A13819	TG 100801	****	***		FGFR1, Fyn, Src
A13820	TG 100572	****	***		FGFR1, Fyn, Src
A14387	ltiratinib (DCC2701)		***		MET, TIE2, TRK
A15073	E-3810	***	**	***	FGFR-1, FGFR-2
A15287	ZM323881		****
A15792	BMS-817378		***		c-Met

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Sorafenib Tosylate (Nexavar)

Catalog No. A10001
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Raf 抑制剂

Sorafenib Tosylate (Nexavar)是几种酪氨酸蛋白激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂的新型小分子抑制剂，Raf-1，wt BRAF和V599E突变型BRAF的IC50为6、22、38 nM。了解更多

Product Citations (12)

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- Paula Sagmeister, .et al. Comparative Response of HCC Cells to TKIs: Modified in vitro Testing and Descriptive Expression Analysis, J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
- Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
- Jindal A, .et al. Milciclib and sorafenib synergistically downregulate c-Myc to suppress tumor growth in an orthotopic murine model of human hepatocellular carcinoma, J Transl Sci, 2020, 7: 1-10
- Mariko Fujisawa, .et al. Involvement of the Interferon Signaling Pathways in Pancreatic Cancer Cells, Anticancer Res, 2020, 40: 4445-4455 PMID: 32727774
- Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298
- Fangyuan Lai, .et al. Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways, Stem Cell Res Ther, 2018, 9: 107 PMID: 29661222
- Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
- Arum Park, .et al. Identification of Transcription Factor YY1 as a Regulator of a Prostate Cancer-Specific Pathway Using Proteomic Analysis, J Cancer, 2017, 8(12): 2303-2311 PMID: 28819434
- Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
- Zhihong Li, .et al. Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3, J Med Chem, 2014, Apr 24;57(8):3430-49 PMID: 24641103
- Hideki Yamaguchi, .et al. Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors, Cancer Sci, 2014, 105(5): 528-536 PMID: 24612061
- Yaping Zhang, .et al. FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia, J Pharmacokinet Pharmacodyn., 2014, 41(6): 675-691 PMID: 25326874
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RAF265 (CHIR-265)

Catalog No. A10773
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RAF/VEGFR 抑制剂

RAF265 (CHIR-265)是一种口服，高度选择性的RAF和VEGFR激酶抑制剂，可控制或正常化VEGFR-2，同时抑制B-raf和c-Raf突变以预防癌症。了解更多

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Raf265 derivative

Catalog No. A10774
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RAF/VEGFR 抑制剂

Raf265 derivative是Raf265的衍生物，Raf265是一种口服，高度选择性的RAF和VEGFR激酶抑制剂，IC50为5至10μM。了解更多

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