mTOR

Inhibitory Selectivity

Catalog No.	Inhibitor Name	mTOR	mTORC1	mTORC2	Other Targets
A10133	Dactolisib	***			p110α,p110γ,p110δ
A10782	Rapamycin	****
A10374	Everolimus	***
A10114	AZD8055	****			DNA-PK,PI3Kδ,PI3Kα
A10906	Temsirolimus	*
A10726	PI-103	*			p110α,p110δ,p110β
A10505	KU-0063794		**	**
A10746	Torkinib	**			p110δ,PDGFR,DNA-PK
A10295	Ridaforolimus	****
A11461	INK 128	****			PI3Kα,PI3Kγ,PI3Kδ
A10997	Voxtalisib Analogue	*			PI3Kγ,PI3Kα,PI3Kδ
A11587	Torin 1	***	***	**	DNA-PK,p110γ,C2α
A11035	Omipalisib		****	****	p110α,p110δ,p110γ
A11056	OSI-027	***	*	*	PI3Kγ,DNA-PK,PI3Kα
A11024	PF-04691502	**			PI3Kδ,PI3Kα,PI3Kγ
A11023	Apitolisib	*			p110α,p110δ,p110γ
A10438	GSK1059615	**			PI3Kα,PI3Kβ,PI3Kδ
A11079	Gedatolisib	****			PI3Kα,PI3Kγ
A10989	WYE-354	***			PI3Kα,PI3Kγ
A11303	Vistusertib	***			P-Akt (S473),pS6 (S235/236)
A11586	Torin 2	****			ATM,ATR,DNA-PK
A11038	WYE-125132	****
A11207	PP121	**			PDGFR,Hck,VEGFR
A11187	WYE-687	***			PI3Kα,PI3Kγ,p38α
A11169	CH5132799	*			PI3Kα,PI3Kγ,PI3Kβ
A11188	WAY-600	**			PI3Kα,PI3Kγ
A13328	ETP-46464	****			ATR,DNA-PK,PI3Kα
A11443	GDC-0349	***			PI3Kα
A12395	XL388	**	**	*	CYP2C9,CYP3A4
A13078	CC-223	**			cFMS,FLT4,DNA-PK
A16276	Voxtalisib	*			PI3Kγ,PI3Kα,PI3Kδ
A11950	Zotarolimus	***
A10389	Tacrolimus
A11162	BGT226				PI3Kα,PI3Kγ,PI3Kβ
A10693	Palomid 529
A10210	Chrysophanic Acid				EGFR
A11537	QL-IX-55
A12480	VS-5584	****			PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A12704	SF1126				PI3K
A12935	PF-04979064	****			PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ, Akt
A14432	GNE-493	***			PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A15175	mTOR inhibitor (mTOR-IN-1)	***
A15508	MHY1485
A16126	LY3023414				PI3Kα, Akt1, DNA-PK

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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VS-5584

Catalog No. A12480
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PI3K/mTOR 抑制剂

VS-5584是一种新型且高度选择性的PI3K/mTOR激酶抑制剂，可用于治疗癌症。了解更多

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Torin 1

Catalog No. A11587
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mTOR 抑制剂

Torin1是mTOR的有效抑制剂，IC50为2-10 nM。了解更多

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- Andromachi Lambrianidou, .et al. mTORC2 deploys the mRNA binding protein IGF2BP1 to regulate c-MYC expression and promote cell survival, Cell Signal, 2021, Apr;80:109912 PMID: 33388443
- Kowalsky AH, .et al. The GATOR2?CmTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation, J Biol Chem, 2020, Feb 14;295(7):1769-1780 PMID: 31915252
- Ashyad Rayhan, .et al. Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function, Biol Open, 2018, Jan 15; 7(1): bio031302 PMID: 29343513
- Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
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mTOR inhibitor (mTOR-IN-1)

Catalog No. A15175
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mTOR 抑制剂

mTOR inhibitor (mTOR-IN-1)是mTOR的有效且选择性的ATP竞争性抑制剂，Ki为1.5 nM。了解更多

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MHY1485

Catalog No. A15508
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mTOR 抑制剂

MHY1485是mTOR激活剂；通过抑制自噬体和溶酶体之间的融合导致LC3II蛋白的积累和自噬体扩大，从而抑制自噬过程。了解更多

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AZD2014 (Vistusertib)

Catalog No. A11303
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mTORC1/2 抑制剂

Vistusertib (AZD2014)是一种新型mTOR抑制剂，无细胞试验中IC50为2.8 nM；对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时，对大多数激酶无或有微弱结合力。了解更多

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- Shuhang Dai, .et al. Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells, Biochim Biophys Acta Mol Cell Res, 2022, Jul;1869(7):119252 PMID: 35271909
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FK-506 (Tacrolimus)

Catalog No. A10389
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mTOR 抑制剂

FK-506 (Tacrolimus)是一种免疫抑制药物，通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物，从而降低T细胞中肽酰脯氨酰异构酶活性。了解更多

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- Ogawa Y, .et al. Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease, Neurobiol Dis, 2018, Oct;118:142-154 PMID: 30026035
- Yuko Okamoto, .et al. In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers, J Drug Deliv Sci Technol, 2018, 47: 62-66
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WYE-354

Catalog No. A10989
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mTOR 抑制剂

WYE-354是一种有效的mTOR细胞渗透抑制剂（IC50 = 4.3 nM），可阻断通过mTOR复合体1（mTORC1）和mTORC2的信号传导。它是PI3Kα（IC50 = 1026 nM）和其他激酶的弱得多的抑制剂。了解更多

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- H Weber ,etc. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice. Oncotarget, 2015, 6(31), 31877.
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QL-IX-55

Catalog No. A11537
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mTORC1/2 抑制剂

QL-IX-55是mTORC1/2的选择性ATP竞争性抑制剂，其IC50分别为50/50/10-50nM，用于人mTORC1/酵母mTORC1/酵母mTORC2。了解更多

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LY3023414

Catalog No. A16126
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PI3K/mTOR Dual 抑制剂

LY3023414是从专利WO/2012097039A1（化合物实施例1）中提取的I类PI3K同种型，mTOR和DNA-PK的口服ATP竞争性抑制剂，对Akt1（pT308）的IC50为64.9 nM，42.1 nM，10.6 nM和19.1 nM。），Akt1（pS473），P70S6（pT389），S6RP（pS240/242）。了解更多

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- Zou Y, .et al. Targeting PI3K-AKT-mTOR by LY3023414 inhibits human skin squamous cell carcinoma cell growth in vitro and in vivo, Biochem Biophys Res Commun, 2017, Aug 19;490(2):385-392 PMID: 28623128
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SAR245409 (XL765, Voxtalisib)

Catalog No. A16276
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PI3K/mTOR dual 抑制剂

SAR245409 (XL765,Voxtalisib)是PI3K/mTOR双激酶抑制剂XL765是口服生物可利用的小分子，靶向PI3K/mTOR信号途径中的磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）激酶的哺乳动物靶标，具有潜在的抗肿瘤活性。了解更多

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GSK2126458 (Omipalisib)

Catalog No. A11035
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mTOR/PI3K 抑制剂,

GSK2126458 (Omipalisib)是一种高选择性的，有效的p110α/β/γ/δ和 mTORC1/2抑制剂，无细胞试验中Ki分别为0.019 nM/0.13 nM/0.024 nM/0.06 nM和0.18 nM/0.3 nM。了解更多

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AZD8055

Catalog No. A10114
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mTOR 抑制剂

AZD8055是一种有效的，选择性的ATP竞争性mTOR激酶抑制剂，IC50为0.8 nM。了解更多

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- L. M. C. Koene, .et al. Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model, ACTN, 2019, June PMID: 31353861
- Helga Weber, .et al. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice, Oncotarget, 2015, Oct 13; 6(31): 31877–31888 PMID: 26397134
- Kentaro Hirose, .et al. Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Dev Biol, 2014, 14: 42. PMID: 25480380
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BEZ235 (NVP-BEZ235, Dactolisib)

Catalog No. A10133
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PI3K/mTOR 抑制剂

BEZ235 (NVP-BEZ235,Dactolisib)是通过与这些酶的ATP结合裂隙结合来抑制PI3K和mTOR激酶活性。了解更多

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- Makoto Koyama, .et al. Low-dose trametinib and Bcl-xL antagonist have a specific antitumor effect in KRAS-mutated colorectal cancer cells, Int J Oncol, 2020, Sep 2 PMID: 32901840
- Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
- Dominik Schulz, .et al. HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances, Am J Cancer Res, 2016, 6(9): 1963-1975 PMID: 27725902
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Rapamycin (Sirolimus)

Catalog No. A10782
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mTOR 抑制剂

Rapamycin (Sirolimus)是通过抑制T细胞和B细胞对白介素2（IL-2）的反应来防止其活化。了解更多

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- R Mahalakshmi, .et al. Hormetic effect of low doses of rapamycin triggers anti-aging cascades in WRL-68 cells by modulating an mTOR-mitochondria cross-talk, Mol Biol Rep, 2022, Jan;49(1):463-476 PMID: 34739690
- Yusuke Murase, .et al. Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells, Oncol Rep, 2022, Apr;47(4):61 PMID: 35088890
- Zhichao Wu, .et al. Prompt Graft Cooling Enhances Cardioprotection during Heart Transplantation Procedures through the Regulation of Mitophagy, Cells, 2021, Oct 27;10(11):2912 PMID: 34831135
- Matthew A Schaller, .et al. Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses, JCI Insight, 2021, Sep 22;6(18):e148003 PMID: 34357881
- Matthew A. Schaller, .et al. In vitro infection of human lung tissue with SARS-CoV-2: Heterogeneity in host defense and therapeutic response, bioRxiv, 2021, January 21
- Ashley VanCleave, .et al. Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway, Oncotarget, 2020, Jul 7; 11(27): 2597-2610 PMID: 32676162
- Y Huang, .et al. STIM1 controls calcineurin/Akt/mTOR/NFATC2?mediated osteoclastogenesis induced by RANKL/M-CSF, Experimental and Therapeutic Medicine, 2020, 20(2), 736-747 PMID: 32742319
- Takuya Hirao, .et al. Altered intracellular signaling by imatinib increases the anti-cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells, Cancer Sci, 2018, Jan; 109(1): 121-131 PMID: 29121435
- Ya-Hui Chen, .et al. The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells, J Diabetes Res, 2016, 2016: 1828071 PMID: 28004006
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PI-103

Catalog No. A10726
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PI3K 抑制剂

PI-103是一种有效的，细胞可渗透的，ATP竞争性磷脂酰肌醇3激酶（PI3K）家族抑制剂，对DNA-PK，PI3K（p110α）和mTOR具有选择性。了解更多

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- Diane Yang, .et al. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes, Diabetes, 2021, Oct;70(10):2419-2429 PMID: 34344789
- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
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GSK1059615

Catalog No. A10438
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mTOR/PI3K 抑制剂

GSK1059615是PI3Kα (IC50 = 2 nM)的强效、可逆、ATP竞争性噻唑烷二酮抑制剂。了解更多

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- Jing Xie, .et al. GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway, Oncotarget, 2017, Aug 1; 8(31): 50814-50823 PMID: 28881606
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Everolimus (RAD001)

Catalog No. A10374
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mTOR 抑制剂

Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物，与西罗莫司作为mTOR抑制剂的作用相似。了解更多

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- Ming-Chun Hung, .et al. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer, Cell Biosci, 2022, 12: 122 PMID: 35918763
- Yusuke Murase, .et al. Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells, Oncol Rep, 2022, Apr;47(4):61 PMID: 35088890
- Gabriela Torres-Flores, .et al. Preparation and Characterization of Liposomal Everolimus by Thin-Film Hydration Technique, Adv Polym Technol, 2020, ID 5462949
- Takaaki Fujimura, .et al. Enhanced antitumor effect of alectinib in combination with cyclin-dependent kinase 4/6 inhibitor against RET-fusion-positive non-small cell lung cancer cells, Cancer Biol Ther, 2020, Sep 1;21(9):863-870 PMID: 32835580
- BD Henriksbo, .et al. Statins Activate the NLRP3 Inflammasome and Impair Insulin Signaling via p38 and mTOR, Am J Physiol Endocrinol Metab, 2020, Jul 1;319(1):E110-E116 PMID: 32421368
- Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127 PMID: 30866995
- Nachi Namatame, .et al. Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines, Oncotarget, 2018, Oct 12; 9(80): 35141-35161 PMID: 30416685
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
- Rieko Ohki, .et al. PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors, Proc Natl Acad Sci U S A, 2014, 111(23): E2404-E2413 PMID: 24912192
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GDC-0980 (Apitolisib, RG7422)

Catalog No. A11023
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mTOR/PI3K 抑制剂

GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。了解更多

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- Kasun Wanigasooriya, .et al. Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer, Front Oncol, 2022, Jul 4;12:920444 PMID: 35860583
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PF-04691502

Catalog No. A11024
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PI3K/mTOR 抑制剂

PF-04691502是PI3K/mTOR激酶抑制剂，也是在PI3K/mTOR信号传导途径中靶向磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）哺乳动物靶标的药物。了解更多

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PP242 (Torkinib)

Catalog No. A10746
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mTOR 抑制剂

PP242 (Torkinib)在mTORC1和mTORC2中都是有效的选择性mTOR抑制剂。了解更多

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- Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127
- Fuse MJ, .et al. Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers, Mol Cancer Ther, 2017, Oct;16(10):2130-2143 PMID: 28751539
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Desmethyl-VS-5584

Catalog No. A10900
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PI3K/mTOR 抑制剂

Desmethyl-VS-5584是VS-5584的去甲基类似物，VS-5584是一种新型且高度选择性的PI3K/mTOR激酶抑制剂。了解更多

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CC-223

Catalog No. A13078
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mTOR 抑制剂

CC-223是一种有效的mTOR激酶抑制剂（IC50 = 16 nM），其敏感性是相关脂质激酶PI3K-alpha（IC50 = 4 uM）的> 150倍。了解更多

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CZ415

Catalog No. A16476
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mTOR inhibitor

CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex. 了解更多

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CC-115

Catalog No. A15779
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mTOR/DNA-PK 抑制剂

CC-115是mTOR/DNA-PK的抑制剂（IC50 = 21/13 nM）。了解更多

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Dactolisib Tosylate

Catalog No. A11327
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dual PI3K and mTOR kinase inhibitor

Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2. 了解更多

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mTOR inhibitor-2

Catalog No. A13035
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mTOR inhibitor

mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates. 了解更多

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HDACs/mTOR Inhibitor 1

Catalog No. A13462
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HDACs/mTOR Inhibitor 1

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies. 了解更多

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LY 303511

Catalog No. A15147
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PI3K 抑制剂

LY303002是LY294002的非活性类似物，是一种mTOR抑制剂，不抑制PI3-K。了解更多

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GNE-493

Catalog No. A14432
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Dual Pan PI3k/mTOR 抑制剂

GNE-493是有效，选择性的pan-PI3-激酶和双重pan-PI3-激酶/mTOR抑制剂，具有潜在的抗癌活性。了解更多

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GNE 477

Catalog No. A14114
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PI3K/mTOR 抑制剂

GNE-477是一种有效的PI3K/mTOR双重抑制剂，PI3Kα的IC50为4 nM，Kiapp为mTOR的IC50为21 nM。了解更多

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42-(2-Tetrazolyl)rapamycin

Catalog No. A21394
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mTOR inhibitor

42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor. 了解更多

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Temsirolimus (Torisel)

Catalog No. A10906
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mTOR 抑制剂

Temsirolimus (Torisel)是mTOR的特异性抑制剂，会干扰调节肿瘤细胞增殖，生长和存活的蛋白质的合成。了解更多

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KU-0063794

Catalog No. A10505
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mTOR 抑制剂

KU-0063794是哺乳动物雷帕霉素靶位的选择性抑制剂(分别为mTORC1和mTORC2，IC50 ~10 nM)。了解更多

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Palomid 529 (P529)

Catalog No. A10693
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AKT 抑制剂

Palomid 529是PI3K/Akt/mTOR途径的双重TORC1/2抑制剂，在血管生成和细胞增殖中具有广泛的活性。了解更多

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WYE-125132 (WYE-132)

Catalog No. A11038
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mTOR 抑制剂

WYE-125132 (WYE-132)是一种高度有效的，ATP竞争性的mTOR抑制剂，IC50为0.19 nM；作用于mTOR比作用于PI3Ks或PI3K相关激酶hSMG1和ATR选择性高。了解更多

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XL765

Catalog No. A10997
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PI3K 抑制剂

XL765是PI3K/mTOR双激酶抑制剂，与单独抑制PI3K激酶或mTOR激酶的药物相比，它的效力更高。了解更多

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OSI-027

Catalog No. A11056
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mTOR 抑制剂

OSI-027是一种有效的，选择性的，可口服生物利用的mTOR激酶抑制剂，可抑制与mTOR的TORC1和TORC2复合物相关的激酶活性。了解更多

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PKI-587 ( Gedatolisib )

Catalog No. A11079
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PI3K/mTOR 抑制剂

PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。了解更多

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NVP-BGT226

Catalog No. A11162
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PI3K 抑制剂

NVP-BGT226，新型磷酸肌醇3-激酶/mTOR双重抑制剂，作用于PI3Kα/β/γ，IC50为4 nM/63 nM/38 nM，在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。了解更多

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CH5132799

Catalog No. A11169
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PI3K 抑制剂

CH5132799是一种新型的I类PI3K抑制剂，尤其对PI3Kα (IC (50) = 0.014μM) 表现出很强的抑制活性。了解更多

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WYE-687

Catalog No. A11187
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mTOR 抑制剂

WYE-687是雷帕霉素（mTOR）哺乳动物靶标的新型ATP竞争性和选择性抑制剂，IC50为7 nM；抑制mTORC1/pS6K(T389)和mTORC2/P-AKT(S473)，但不抑制P-AKT(T308)，作用于mTOR比作用于PI3Kα(>100倍)和PI3Kγ(>500倍)选择性高。了解更多

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WAY-600

Catalog No. A11188
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mTOR 抑制剂

WAY-600是一种有效的，ATP竞争性的，选择性的mTOR抑制剂，IC50为9 nM；抑制mTORC1/P-S6K(T389)和mTORC2/P-AKT(S473)，但不抑制P-AKT(T308)；作用于mTOR比作用于PI3Kα(>100倍)和PI3Kγ(>500倍)选择性高。了解更多

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PP121

Catalog No. A11207
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PI3K 抑制剂

PP121是一种作用于PDGFR，Hck，mTOR，VEGFR2，Src和Abl的多靶点抑制剂，IC50分别为2 nM，8 nM，10 nM，12 nM，14 nM和18 nM，也抑制DNA-PK，IC50为60 nM。了解更多

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Deforolimus (Ridaforolimus)

Catalog No. A10295
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mTOR 抑制剂

Deforolimus (Ridaforolimus)是mTOR蛋白的研究目标靶向小分子抑制剂。阻断mTOR通过干扰细胞生长，分裂，代谢和血管生成，在癌细胞中产生饥饿样的效应。了解更多

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INK 128 (MLN0128)

Catalog No. A11461
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mTOR 抑制剂

INK 128是TORC1/2抑制剂，也是具有潜在抗肿瘤活性的猛禽mTOR（TOR复合物1或TORC1）和raptor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。了解更多

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- Ashlyn Parkhurst, .et al. Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors, Cell Death Dis, 2022, Apr 28;13(4):410 PMID: 35484114
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GDC-0349

Catalog No. A11443
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mTOR 抑制剂

GDC-0349是一种有效的，选择性的，ATP竞争性的mTOR抑制剂，Ki为3.8 nM，比作用于PI3Kα和其他266种激酶的抑制效果高790倍。了解更多

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Zotarolimus

Catalog No. A11950
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mTOR 抑制剂

Zotarolimus是一种免疫抑制剂，可以抑制FKBP-12结合的IC50为2.8nM。。它是雷帕霉素的半合成衍生物。它设计用于以磷酸胆碱为载体的支架。了解更多

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Torin 2

Catalog No. A11586
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mTOR 抑制剂

Torin 2 是有效的选择性mTOR抑制剂 (IC50 = 2.1 nM)。在PI3K上显示mTOR的800倍细胞选择性（mTOR和PI3K的细胞EC50值分别为0.25和200 nM）。了解更多

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- Diane Yang, .et al. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes, Diabetes, 2021, Oct;70(10):2419-2429 PMID: 34344789
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XL388

Catalog No. A12395
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mTOR 抑制剂

XL388是哺乳动物雷帕霉素靶标(mTOR)的一类新型高效、选择性、ATP竞争性生物可利用抑制剂。了解更多

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ETP-46464

Catalog No. A13328
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ATR 抑制剂

ETP-46464是一种有效的选择性ATR抑制剂，IC50为25 nM。了解更多

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- Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458