mTOR

Inhibitory Selectivity

Catalog No.	Inhibitor Name	mTOR	mTORC1	mTORC2	Other Targets
A10133	Dactolisib	***			p110α,p110γ,p110δ
A10782	Rapamycin	****
A10374	Everolimus	***
A10114	AZD8055	****			DNA-PK,PI3Kδ,PI3Kα
A10906	Temsirolimus	*
A10726	PI-103	*			p110α,p110δ,p110β
A10505	KU-0063794		**	**
A10746	Torkinib	**			p110δ,PDGFR,DNA-PK
A10295	Ridaforolimus	****
A11461	INK 128	****			PI3Kα,PI3Kγ,PI3Kδ
A10997	Voxtalisib Analogue	*			PI3Kγ,PI3Kα,PI3Kδ
A11587	Torin 1	***	***	**	DNA-PK,p110γ,C2α
A11035	Omipalisib		****	****	p110α,p110δ,p110γ
A11056	OSI-027	***	*	*	PI3Kγ,DNA-PK,PI3Kα
A11024	PF-04691502	**			PI3Kδ,PI3Kα,PI3Kγ
A11023	Apitolisib	*			p110α,p110δ,p110γ
A10438	GSK1059615	**			PI3Kα,PI3Kβ,PI3Kδ
A11079	Gedatolisib	****			PI3Kα,PI3Kγ
A10989	WYE-354	***			PI3Kα,PI3Kγ
A11303	Vistusertib	***			P-Akt (S473),pS6 (S235/236)
A11586	Torin 2	****			ATM,ATR,DNA-PK
A11038	WYE-125132	****
A11207	PP121	**			PDGFR,Hck,VEGFR
A11187	WYE-687	***			PI3Kα,PI3Kγ,p38α
A11169	CH5132799	*			PI3Kα,PI3Kγ,PI3Kβ
A11188	WAY-600	**			PI3Kα,PI3Kγ
A13328	ETP-46464	****			ATR,DNA-PK,PI3Kα
A11443	GDC-0349	***			PI3Kα
A12395	XL388	**	**	*	CYP2C9,CYP3A4
A13078	CC-223	**			cFMS,FLT4,DNA-PK
A16276	Voxtalisib	*			PI3Kγ,PI3Kα,PI3Kδ
A11950	Zotarolimus	***
A10389	Tacrolimus
A11162	BGT226				PI3Kα,PI3Kγ,PI3Kβ
A10693	Palomid 529
A10210	Chrysophanic Acid				EGFR
A11537	QL-IX-55
A12480	VS-5584	****			PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A12704	SF1126				PI3K
A12935	PF-04979064	****			PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ, Akt
A14432	GNE-493	***			PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A15175	mTOR inhibitor (mTOR-IN-1)	***
A15508	MHY1485
A16126	LY3023414				PI3Kα, Akt1, DNA-PK

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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PKI-587 ( Gedatolisib )

Catalog No. A11079
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PI3K/mTOR 抑制剂

PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。了解更多

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